From Wikipedia, the free encyclopedia
Protein-coding gene in the species Homo sapiens
Ribonucleases P/MRP protein subunit POP1 is a
protein that in humans is encoded by the POP1
gene .
[5]
[6]
Function
POP1 is a protein subunit of two different small
nucleolar
ribonucleoprotein complexes: the
endoribonuclease for mitochondrial RNA processing complex and the
ribonuclease P complex. This protein is a
ribonuclease that localizes to the nucleus and functions in pre-RNA processing.
[7]
Clinical significance
POP1 is also an autoantigen in patients with connective tissue diseases. Mutations in the POP1 gene result in severe anauxetic
dysplasia .
[8]
Interactions
POP1 (gene) has been shown to
interact with
POP4 .
[9]
References
^
a
b
c
GRCh38: Ensembl release 89: ENSG00000104356 –
Ensembl , May 2017
^
a
b
c
GRCm38: Ensembl release 89: ENSMUSG00000022325 –
Ensembl , May 2017
^
"Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
^
"Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
^ Pluk H, van Eenennaam H, Rutjes SA, Pruijn GJ, van Venrooij WJ (Apr 1999).
"RNA-protein interactions in the human RNase MRP ribonucleoprotein complex" . RNA . 5 (4): 512–24.
doi :
10.1017/S1355838299982079 .
PMC
1369778 .
PMID
10199568 .
^ Lygerou Z, Pluk H, van Venrooij WJ, Seraphin B (Jan 1997).
"hPop1: an autoantigenic protein subunit shared by the human RNase P and RNase MRP ribonucleoproteins" . EMBO J . 15 (21): 5936–48.
doi :
10.1002/j.1460-2075.1996.tb00980.x .
PMC
452370 .
PMID
8918471 .
^
"Entrez Gene: POP1 processing of precursor 1, ribonuclease P/MRP subunit (S. cerevisiae)" .
^ Glazov EA, Zankl, A, Donskoi, M, Kenna, TJ, Thomas, GP, Clark, GR, Duncan, EL, Brown, MA (Mar 2011).
"Whole-Exome Re-Sequencing in a Family Quartet Identifies POP1 Mutations As the Cause of a Novel Skeletal Dysplasia" . PLOS Genetics . 7 (3): e1002027.
doi :
10.1371/journal.pgen.1002027 .
PMC
3063761 .
PMID
21455487 .
^ Welting TJ, van Venrooij Walther J, Pruijn Ger J M (2004).
"Mutual interactions between subunits of the human RNase MRP ribonucleoprotein complex" . Nucleic Acids Res . 32 (7). England: 2138–46.
doi :
10.1093/nar/gkh539 .
PMC
407822 .
PMID
15096576 .
Further reading
Nomura N, Nagase T, Miyajima N, et al. (1995).
"Prediction of the coding sequences of unidentified human genes. II. The coding sequences of 40 new genes (KIAA0041-KIAA0080) deduced by analysis of cDNA clones from human cell line KG-1" . DNA Res . 1 (5): 223–9.
doi :
10.1093/dnares/1.5.223 .
PMID
7584044 .
Schmiedeknecht G, Büchler C, Schmitz G (1998). "A bidirectional promoter connects the p14.5 gene to the gene for RNase P and RNase MRP protein subunit hPOP1". Biochem. Biophys. Res. Commun . 241 (1): 59–67.
doi :
10.1006/bbrc.1997.7772 .
PMID
9405234 .
Dundr M, Olson MO (1999).
"Partially processed pre-rRNA is preserved in association with processing components in nucleolus-derived foci during mitosis" . Mol. Biol. Cell . 9 (9): 2407–22.
doi :
10.1091/mbc.9.9.2407 .
PMC
25507 .
PMID
9725903 .
Jiang T, Guerrier-Takada C, Altman S (2001).
"Protein-RNA interactions in the subunits of human nuclear RNase P." RNA . 7 (7): 937–41.
doi :
10.1017/S1355838201010299 .
PMC
1370153 .
PMID
11455963 .
van Eenennaam H, van der Heijden A, Janssen RJ, et al. (2002).
"Basic domains target protein subunits of the RNase MRP complex to the nucleolus independently of complex association" . Mol. Biol. Cell . 12 (11): 3680–9.
doi :
10.1091/mbc.12.11.3680 .
PMC
60285 .
PMID
11694598 .
Andersen JS, Lyon CE, Fox AH, et al. (2002).
"Directed proteomic analysis of the human nucleolus" . Curr. Biol . 12 (1): 1–11.
Bibcode :
2002CBio...12....1A .
doi :
10.1016/S0960-9822(01)00650-9 .
PMID
11790298 .
S2CID
14132033 .
Strausberg RL, Feingold EA, Grouse LH, et al. (2003).
"Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences" . Proc. Natl. Acad. Sci. U.S.A . 99 (26): 16899–903.
Bibcode :
2002PNAS...9916899M .
doi :
10.1073/pnas.242603899 .
PMC
139241 .
PMID
12477932 .
Welting TJ, van Venrooij WJ, Pruijn GJ (2004).
"Mutual interactions between subunits of the human RNase MRP ribonucleoprotein complex" . Nucleic Acids Res . 32 (7): 2138–46.
doi :
10.1093/nar/gkh539 .
PMC
407822 .
PMID
15096576 .
Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004).
"Large-scale characterization of HeLa cell nuclear phosphoproteins" . Proc. Natl. Acad. Sci. U.S.A . 101 (33): 12130–5.
Bibcode :
2004PNAS..10112130B .
doi :
10.1073/pnas.0404720101 .
PMC
514446 .
PMID
15302935 .
Andersen JS, Lam YW, Leung AK, et al. (2005). "Nucleolar proteome dynamics". Nature . 433 (7021): 77–83.
Bibcode :
2005Natur.433...77A .
doi :
10.1038/nature03207 .
PMID
15635413 .
S2CID
4344740 .
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature . 437 (7062): 1173–8.
Bibcode :
2005Natur.437.1173R .
doi :
10.1038/nature04209 .
PMID
16189514 .
S2CID
4427026 .
Welting TJ, Kikkert BJ, van Venrooij WJ, Pruijn GJ (2006).
"Differential association of protein subunits with the human RNase MRP and RNase P complexes" . RNA . 12 (7): 1373–82.
doi :
10.1261/rna.2293906 .
PMC
1484433 .
PMID
16723659 .
This article incorporates text from the
United States National Library of Medicine , which is in the
public domain .