Phosphomannomutase 1 is an
enzyme that in humans is encoded by the PMM1gene.[5][6][7]
Phosphomannomutase catalyzes the conversion between D-mannose 6-phosphate and D-mannose 1-phosphate which is a substrate for
GDP-mannose synthesis. GDP-mannose is used for synthesis of dolichol-phosphate-mannose, which is essential for N-linked glycosylation and thus the secretion of several
glycoproteins as well as for the synthesis of
Glycosylphosphatidylinositol (GPI) anchored proteins.[7]
^ČeŘovský V (2007). "Identification of three novel peptides isolated from the venom of the neotropical social wasp Polistes major major". Journal of Peptide Science. 13 (7): 445–450.
doi:
10.1002/psc.860.
PMID17559065.
S2CID41958134.
Further reading
Wada Y, Sakamoto M (1997). "Isolation of the human phosphomannomutase gene (PMM1) and assignment to chromosome 22q13". Genomics. 39 (3): 416–7.
doi:
10.1006/geno.1996.4487.
PMID9119384.
Barone R, Sturiale L, Fiumara A, et al. (2007). "Borderline mental development in a congenital disorder of glycosylation (CDG) type Ia patient with multisystemic involvement (intermediate phenotype)". J. Inherit. Metab. Dis. 30 (1): 107.
doi:
10.1007/s10545-006-0486-6.
PMID17186415.
S2CID12016939.
Phosphomannomutase 1 is an
enzyme that in humans is encoded by the PMM1gene.[5][6][7]
Phosphomannomutase catalyzes the conversion between D-mannose 6-phosphate and D-mannose 1-phosphate which is a substrate for
GDP-mannose synthesis. GDP-mannose is used for synthesis of dolichol-phosphate-mannose, which is essential for N-linked glycosylation and thus the secretion of several
glycoproteins as well as for the synthesis of
Glycosylphosphatidylinositol (GPI) anchored proteins.[7]
^ČeŘovský V (2007). "Identification of three novel peptides isolated from the venom of the neotropical social wasp Polistes major major". Journal of Peptide Science. 13 (7): 445–450.
doi:
10.1002/psc.860.
PMID17559065.
S2CID41958134.
Further reading
Wada Y, Sakamoto M (1997). "Isolation of the human phosphomannomutase gene (PMM1) and assignment to chromosome 22q13". Genomics. 39 (3): 416–7.
doi:
10.1006/geno.1996.4487.
PMID9119384.
Barone R, Sturiale L, Fiumara A, et al. (2007). "Borderline mental development in a congenital disorder of glycosylation (CDG) type Ia patient with multisystemic involvement (intermediate phenotype)". J. Inherit. Metab. Dis. 30 (1): 107.
doi:
10.1007/s10545-006-0486-6.
PMID17186415.
S2CID12016939.