From Wikipedia, the free encyclopedia
Protein-coding gene in the species Homo sapiens
Zinc finger protein PLAGL2 is a
protein that in humans is encoded by the PLAGL2
gene .
[5]
[6]
[7]
Zinc finger protein PLAGL2 is a
zinc finger protein that recognizes DNA and/or RNA.
[7]
The gene has seen in
gliomas to suppress cellular differentiation and thus encourage cells to become more
stem cell like. Such plasticity is seen in glioma cells, together with the ignorance to differentiation factors.
[8]
References
^
a
b
c
GRCh38: Ensembl release 89: ENSG00000126003 –
Ensembl , May 2017
^
a
b
c
GRCm38: Ensembl release 89: ENSMUSG00000051413 –
Ensembl , May 2017
^
"Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
^
"Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
^ Landrette SF, Kuo YH, Hensen K, Barjesteh van Waalwijk van Doorn-Khosrovani S, Perrat PN, Van de Ven WJ, Delwel R, Castilla LH (Mar 2005).
"Plag1 and Plagl2 are oncogenes that induce acute myeloid leukemia in cooperation with Cbfb-MYH11" . Blood . 105 (7): 2900–7.
doi :
10.1182/blood-2004-09-3630 .
PMID
15585652 .
^ Zheng G, Ning J, Yang YC (Oct 2007).
"PLAGL2 controls the stability of Pirh2, an E3 ubiquitin ligase for p53" . Biochem Biophys Res Commun . 364 (2): 344–50.
doi :
10.1016/j.bbrc.2007.10.003 .
PMC
2708094 .
PMID
17950244 .
^
a
b
"Entrez Gene: PLAGL2 pleiomorphic adenoma gene-like 2" .
^ Zheng H, Ying H, Wiedemeyer R, Yan H, Quayle SN, Ivanova EV, Paik JH, Zhang H, Xiao Y, Perry SR, Hu J, Vinjamoori A, Gan B, Sahin E, Chheda MG, Brennan C, Wang YA, Hahn WC, Chin L, DePinho RA (May 2010).
"PLAGL2 regulates Wnt signaling to impede differentiation in neural stem cells and glioma" . Cancer Cell . 17 (5): 497–509.
doi :
10.1016/j.ccr.2010.03.020 .
PMC
2900858 .
PMID
20478531 .
Further reading
Guo Y, Yang MC, Weissler JC, Yang YS (2007).
"PLAGL2 Translocation and SP-C Promoter Activity – A Cellular Response of Lung Cells to Hypoxia" . Biochem. Biophys. Res. Commun . 360 (3): 659–65.
doi :
10.1016/j.bbrc.2007.06.106 .
PMC
2084061 .
PMID
17618602 .
Ammons MC, Siemsen DW, Nelson-Overton LK, et al. (2007).
"Binding of pleomorphic adenoma gene-like 2 to the tumor necrosis factor (TNF)-alpha-responsive region of the NCF2 promoter regulates p67(phox) expression and NADPH oxidase activity" . J. Biol. Chem . 282 (24): 17941–52.
doi :
10.1074/jbc.M610618200 .
PMID
17462995 .
Gerhard DS, Wagner L, Feingold EA, et al. (2004).
"The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)" . Genome Res . 14 (10B): 2121–7.
doi :
10.1101/gr.2596504 .
PMC
528928 .
PMID
15489334 .
Yang MC, Weissler JC, Terada LS, et al. (2005). "Pleiomorphic adenoma gene-like-2, a zinc finger protein, transactivates the surfactant protein-C promoter". Am. J. Respir. Cell Mol. Biol . 32 (1): 35–43.
CiteSeerX
10.1.1.325.6715 .
doi :
10.1165/rcmb.2003-0422OC .
PMID
15361364 .
Strausberg RL, Feingold EA, Grouse LH, et al. (2003).
"Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences" . Proc. Natl. Acad. Sci. U.S.A . 99 (26): 16899–903.
Bibcode :
2002PNAS...9916899M .
doi :
10.1073/pnas.242603899 .
PMC
139241 .
PMID
12477932 .
Deloukas P, Matthews LH, Ashurst J, et al. (2002).
"The DNA sequence and comparative analysis of human chromosome 20" . Nature . 414 (6866): 865–71.
Bibcode :
2001Natur.414..865D .
doi :
10.1038/414865a .
PMID
11780052 .
Furukawa T, Adachi Y, Fujisawa J, et al. (2001).
"Involvement of PLAGL2 in activation of iron deficient- and hypoxia-induced gene expression in mouse cell lines" . Oncogene . 20 (34): 4718–27.
doi :
10.1038/sj.onc.1204647 .
PMID
11498794 .
Kas K, Voz ML, Hensen K, et al. (1998).
"Transcriptional activation capacity of the novel PLAG family of zinc finger proteins" . J. Biol. Chem . 273 (36): 23026–32.
doi :
10.1074/jbc.273.36.23026 .
PMID
9722527 .
Nagase T, Seki N, Ishikawa K, et al. (1996).
"Prediction of the coding sequences of unidentified human genes. V. The coding sequences of 40 new genes (KIAA0161-KIAA0200) deduced by analysis of cDNA clones from human cell line KG-1" . DNA Res . 3 (1): 17–24.
doi :
10.1093/dnares/3.1.17 .
PMID
8724849 .