GPI-anchor transamidase is an
enzyme that in humans is encoded by the PIGKgene.[5][6]
This gene encodes a member of the cysteine protease family C13 that is involved in glycosylphosphatidylinositol (GPI)-anchor biosynthesis. The GPI-anchor is a glycolipid found on many blood cells and serves to anchor proteins to the cell surface. This protein is a member of the multisubunit enzyme GPI transamidase and is thought to be its enzymatic component. GPI transamidase mediates GPI anchoring in the endoplasmic reticulum, by catalyzing the transfer of fully assembled GPI units to proteins.[6]
Meyer U, Benghezal M, Imhof I, Conzelmann A (2000). "Active site determination of Gpi8p, a caspase-related enzyme required for glycosylphosphatidylinositol anchor addition to proteins". Biochemistry. 39 (12): 3461–71.
doi:
10.1021/bi992186o.
PMID10727241.
Chen R, Anderson V, Hiroi Y, Medof ME (2003). "Proprotein interaction with the GPI transamidase". J. Cell. Biochem. 88 (5): 1025–37.
doi:
10.1002/jcb.10439.
PMID12616539.
S2CID12875152.
GPI-anchor transamidase is an
enzyme that in humans is encoded by the PIGKgene.[5][6]
This gene encodes a member of the cysteine protease family C13 that is involved in glycosylphosphatidylinositol (GPI)-anchor biosynthesis. The GPI-anchor is a glycolipid found on many blood cells and serves to anchor proteins to the cell surface. This protein is a member of the multisubunit enzyme GPI transamidase and is thought to be its enzymatic component. GPI transamidase mediates GPI anchoring in the endoplasmic reticulum, by catalyzing the transfer of fully assembled GPI units to proteins.[6]
Meyer U, Benghezal M, Imhof I, Conzelmann A (2000). "Active site determination of Gpi8p, a caspase-related enzyme required for glycosylphosphatidylinositol anchor addition to proteins". Biochemistry. 39 (12): 3461–71.
doi:
10.1021/bi992186o.
PMID10727241.
Chen R, Anderson V, Hiroi Y, Medof ME (2003). "Proprotein interaction with the GPI transamidase". J. Cell. Biochem. 88 (5): 1025–37.
doi:
10.1002/jcb.10439.
PMID12616539.
S2CID12875152.