From Wikipedia, the free encyclopedia
Protein-coding gene in the species Homo sapiens
Peroxisomal membrane protein PEX13 is a
protein that in humans is encoded by the PEX13
gene.
[4]
[5] It located on chromosome 2 next to
KIAA1841
PEX13 has been shown to
interact with
PEX14,
[6]
PEX5
[6]
[7] and
PEX19.
[8]
[9]
- ^
a
b
c
GRCh38: Ensembl release 89: ENSG00000162928 –
Ensembl, May 2017
-
^
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
-
^
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
-
^ Björkman J, Stetten G, Moore CS, Gould SJ, Crane DI (December 1998).
"Genomic structure of PEX13, a candidate peroxisome biogenesis disorder gene". Genomics. 54 (3): 521–8.
doi:
10.1006/geno.1998.5520.
PMID
9878256.
-
^
"Entrez Gene: PEX13 peroxisome biogenesis factor 13".
- ^
a
b Otera H, Setoguchi K, Hamasaki M, Kumashiro T, Shimizu N, Fujiki Y (March 2002).
"Peroxisomal targeting signal receptor Pex5p interacts with cargoes and import machinery components in a spatiotemporally differentiated manner: conserved Pex5p WXXXF/Y motifs are critical for matrix protein import". Molecular and Cellular Biology. 22 (6): 1639–55.
doi:
10.1128/MCB.22.6.1639-1655.2002.
PMC
135613.
PMID
11865044.
-
^ Gould SJ, Kalish JE, Morrell JC, Bjorkman J, Urquhart AJ, Crane DI (October 1996).
"Pex13p is an SH3 protein of the peroxisome membrane and a docking factor for the predominantly cytoplasmic PTs1 receptor". The Journal of Cell Biology. 135 (1): 85–95.
doi:
10.1083/jcb.135.1.85.
PMC
2121023.
PMID
8858165.
-
^ Sacksteder KA, Jones JM, South ST, Li X, Liu Y, Gould SJ (March 2000).
"PEX19 binds multiple peroxisomal membrane proteins, is predominantly cytoplasmic, and is required for peroxisome membrane synthesis". The Journal of Cell Biology. 148 (5): 931–44.
doi:
10.1083/jcb.148.5.931.
PMC
2174547.
PMID
10704444.
-
^ Fransen M, Wylin T, Brees C, Mannaerts GP, Van Veldhoven PP (July 2001).
"Human pex19p binds peroxisomal integral membrane proteins at regions distinct from their sorting sequences". Molecular and Cellular Biology. 21 (13): 4413–24.
doi:
10.1128/MCB.21.13.4413-4424.2001.
PMC
87101.
PMID
11390669.
- Gould SJ, Kalish JE, Morrell JC, Bjorkman J, Urquhart AJ, Crane DI (October 1996).
"Pex13p is an SH3 protein of the peroxisome membrane and a docking factor for the predominantly cytoplasmic PTs1 receptor". The Journal of Cell Biology. 135 (1): 85–95.
doi:
10.1083/jcb.135.1.85.
PMC
2121023.
PMID
8858165.
- Albertini M, Rehling P, Erdmann R, Girzalsky W, Kiel JA, Veenhuis M, Kunau WH (April 1997).
"Pex14p, a peroxisomal membrane protein binding both receptors of the two PTS-dependent import pathways" (PDF). Cell. 89 (1): 83–92.
doi:
10.1016/S0092-8674(00)80185-3.
PMID
9094717.
S2CID
18878596.
- Fransen M, Terlecky SR, Subramani S (July 1998).
"Identification of a human PTS1 receptor docking protein directly required for peroxisomal protein import". Proceedings of the National Academy of Sciences of the United States of America. 95 (14): 8087–92.
Bibcode:
1998PNAS...95.8087F.
doi:
10.1073/pnas.95.14.8087.
PMC
20933.
PMID
9653144.
- Girzalsky W, Rehling P, Stein K, Kipper J, Blank L, Kunau WH, Erdmann R (March 1999).
"Involvement of Pex13p in Pex14p localization and peroxisomal targeting signal 2-dependent protein import into peroxisomes". The Journal of Cell Biology. 144 (6): 1151–62.
doi:
10.1083/jcb.144.6.1151.
PMC
2150583.
PMID
10087260.
- Shimozawa N, Suzuki Y, Zhang Z, Imamura A, Toyama R, Mukai S, et al. (June 1999).
"Nonsense and temperature-sensitive mutations in PEX13 are the cause of complementation group H of peroxisome biogenesis disorders". Human Molecular Genetics. 8 (6): 1077–83.
doi:
10.1093/hmg/8.6.1077.
PMID
10332040.
- Toyama R, Mukai S, Itagaki A, Tamura S, Shimozawa N, Suzuki Y, et al. (September 1999).
"Isolation, characterization and mutation analysis of PEX13-defective Chinese hamster ovary cell mutants". Human Molecular Genetics. 8 (9): 1673–81.
doi:
10.1093/hmg/8.9.1673.
PMID
10441330.
- Liu Y, Björkman J, Urquhart A, Wanders RJ, Crane DI, Gould SJ (September 1999).
"PEX13 is mutated in complementation group 13 of the peroxisome-biogenesis disorders". American Journal of Human Genetics. 65 (3): 621–34.
doi:
10.1086/302534.
PMC
1377968.
PMID
10441568.
- Sacksteder KA, Jones JM, South ST, Li X, Liu Y, Gould SJ (March 2000).
"PEX19 binds multiple peroxisomal membrane proteins, is predominantly cytoplasmic, and is required for peroxisome membrane synthesis". The Journal of Cell Biology. 148 (5): 931–44.
doi:
10.1083/jcb.148.5.931.
PMC
2174547.
PMID
10704444.
- Fransen M, Wylin T, Brees C, Mannaerts GP, Van Veldhoven PP (July 2001).
"Human pex19p binds peroxisomal integral membrane proteins at regions distinct from their sorting sequences". Molecular and Cellular Biology. 21 (13): 4413–24.
doi:
10.1128/MCB.21.13.4413-4424.2001.
PMC
87101.
PMID
11390669.
- Jones JM, Morrell JC, Gould SJ (June 2001).
"Multiple distinct targeting signals in integral peroxisomal membrane proteins". The Journal of Cell Biology. 153 (6): 1141–50.
doi:
10.1083/jcb.153.6.1141.
PMC
2192020.
PMID
11402059.
- Otera H, Setoguchi K, Hamasaki M, Kumashiro T, Shimizu N, Fujiki Y (March 2002).
"Peroxisomal targeting signal receptor Pex5p interacts with cargoes and import machinery components in a spatiotemporally differentiated manner: conserved Pex5p WXXXF/Y motifs are critical for matrix protein import". Molecular and Cellular Biology. 22 (6): 1639–55.
doi:
10.1128/MCB.22.6.1639-1655.2002.
PMC
135613.
PMID
11865044.
- Fransen M, Brees C, Ghys K, Amery L, Mannaerts GP, Ladant D, Van Veldhoven PP (March 2002).
"Analysis of mammalian peroxin interactions using a non-transcription-based bacterial two-hybrid assay". Molecular & Cellular Proteomics. 1 (3): 243–52.
doi:
10.1074/mcp.M100025-MCP200.
PMID
12096124.
- Fransen M, Vastiau I, Brees C, Brys V, Mannaerts GP, Van Veldhoven PP (March 2004).
"Potential role for Pex19p in assembly of PTS-receptor docking complexes". The Journal of Biological Chemistry. 279 (13): 12615–24.
doi:
10.1074/jbc.M304941200.
PMID
14715663.
- Hashimoto K, Kato Z, Nagase T, Shimozawa N, Kuwata K, Omoya K, et al. (August 2005).
"Molecular mechanism of a temperature-sensitive phenotype in peroxisomal biogenesis disorder". Pediatric Research. 58 (2): 263–9.
doi:
10.1203/01.PDR.0000169984.89199.69.
PMID
16006427.
- Nguyen T, Bjorkman J, Paton BC, Crane DI (February 2006).
"Failure of microtubule-mediated peroxisome division and trafficking in disorders with reduced peroxisome abundance". Journal of Cell Science. 119 (Pt 4): 636–45.
doi:
10.1242/jcs.02776.
hdl:
2440/23242.
PMID
16449325.