High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A is an
enzyme that in humans is encoded by the PDE9Agene.[5][6]
The protein encoded by this gene catalyzes the
hydrolysis of
cAMP and
cGMP to their corresponding
monophosphates. The encoded protein plays a role in
signal transduction by regulating the intracellular concentration of these cyclic nucleotides. Multiple
transcript variants encoding several different
isoforms have been found for this gene.[6]
^Verhoest PR, Fonseca KR, Hou X, et al. (2012). "Design and discovery of 6-[(3S,4S)-4-methyl-1-(pyrimidin-2-ylmethyl)pyrrolidin-3-yl]-1-(tetrahydro-2H-pyran-4-yl)-1,5-dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-one (PF-04447943), a selective brain penetrant PDE9A inhibitor for the treatment of cognitive disorders". J. Med. Chem. 55 (21): 9045–54.
doi:
10.1021/jm3007799.
PMID22780914.
^Hutson PH, Finger EN, Magliaro BC, et al. (2011). "The selective phosphodiesterase 9 (PDE9) inhibitor PF-04447943 (6-[(3S,4S)-4-methyl-1-(pyrimidin-2-ylmethyl)pyrrolidin-3-yl]-1-(tetrahydro-2H-pyran-4-yl)-1,5-dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-one) enhances synaptic plasticity and cognitive function in rodents". Neuropharmacology. 61 (4): 665–76.
doi:
10.1016/j.neuropharm.2011.05.009.
PMID21619887.
S2CID143527784.
Further reading
Guipponi M, Scott HS, Kudoh J, et al. (1998). "Identification and characterization of a novel cyclic nucleotide phosphodiesterase gene (PDE9A) that maps to 21q22.3: alternative splicing of mRNA transcripts, genomic structure and sequence". Hum. Genet. 103 (4): 386–92.
doi:
10.1007/s004390050838.
PMID9856478.
S2CID24883234.
Rentero C, Monfort A, Puigdomènech P (2003). "Identification and distribution of different mRNA variants produced by differential splicing in the human phosphodiesterase 9A gene". Biochem. Biophys. Res. Commun. 301 (3): 686–92.
doi:
10.1016/S0006-291X(03)00021-4.
PMID12565835.
Wang P, Wu P, Egan RW, Billah MM (2003). "Identification and characterization of a new human type 9 cGMP-specific phosphodiesterase splice variant (PDE9A5). Differential tissue distribution and subcellular localization of PDE9A variants". Gene. 314: 15–27.
doi:
10.1016/S0378-1119(03)00733-9.
PMID14527714.
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A is an
enzyme that in humans is encoded by the PDE9Agene.[5][6]
The protein encoded by this gene catalyzes the
hydrolysis of
cAMP and
cGMP to their corresponding
monophosphates. The encoded protein plays a role in
signal transduction by regulating the intracellular concentration of these cyclic nucleotides. Multiple
transcript variants encoding several different
isoforms have been found for this gene.[6]
^Verhoest PR, Fonseca KR, Hou X, et al. (2012). "Design and discovery of 6-[(3S,4S)-4-methyl-1-(pyrimidin-2-ylmethyl)pyrrolidin-3-yl]-1-(tetrahydro-2H-pyran-4-yl)-1,5-dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-one (PF-04447943), a selective brain penetrant PDE9A inhibitor for the treatment of cognitive disorders". J. Med. Chem. 55 (21): 9045–54.
doi:
10.1021/jm3007799.
PMID22780914.
^Hutson PH, Finger EN, Magliaro BC, et al. (2011). "The selective phosphodiesterase 9 (PDE9) inhibitor PF-04447943 (6-[(3S,4S)-4-methyl-1-(pyrimidin-2-ylmethyl)pyrrolidin-3-yl]-1-(tetrahydro-2H-pyran-4-yl)-1,5-dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-one) enhances synaptic plasticity and cognitive function in rodents". Neuropharmacology. 61 (4): 665–76.
doi:
10.1016/j.neuropharm.2011.05.009.
PMID21619887.
S2CID143527784.
Further reading
Guipponi M, Scott HS, Kudoh J, et al. (1998). "Identification and characterization of a novel cyclic nucleotide phosphodiesterase gene (PDE9A) that maps to 21q22.3: alternative splicing of mRNA transcripts, genomic structure and sequence". Hum. Genet. 103 (4): 386–92.
doi:
10.1007/s004390050838.
PMID9856478.
S2CID24883234.
Rentero C, Monfort A, Puigdomènech P (2003). "Identification and distribution of different mRNA variants produced by differential splicing in the human phosphodiesterase 9A gene". Biochem. Biophys. Res. Commun. 301 (3): 686–92.
doi:
10.1016/S0006-291X(03)00021-4.
PMID12565835.
Wang P, Wu P, Egan RW, Billah MM (2003). "Identification and characterization of a new human type 9 cGMP-specific phosphodiesterase splice variant (PDE9A5). Differential tissue distribution and subcellular localization of PDE9A variants". Gene. 314: 15–27.
doi:
10.1016/S0378-1119(03)00733-9.
PMID14527714.