High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A is an
enzyme that in humans is encoded by the PDE8Agene.[5][6] Work by Sebastiaan Bol et al. showed that 5 different
transcript variants and their corresponding
isoforms are
expressed in human
macrophages, and suggests that this protein may be required by
HIV-1 for its
replication.[7]
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^Fisher DA, Smith JF, Pillar JS, St Denis SH, Cheng JB (Jul 1998). "Isolation and characterization of PDE8A, a novel human cAMP-specific phosphodiesterase". Biochem Biophys Res Commun. 246 (3): 570–577.
doi:
10.1006/bbrc.1998.8684.
PMID9618252.
Gamanuma M, Yuasa K, Sasaki T, et al. (2003). "Comparison of enzymatic characterization and gene organization of cyclic nucleotide phosphodiesterase 8 family in humans". Cell. Signal. 15 (6): 565–574.
doi:
10.1016/S0898-6568(02)00146-8.
PMID12681444.
High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A is an
enzyme that in humans is encoded by the PDE8Agene.[5][6] Work by Sebastiaan Bol et al. showed that 5 different
transcript variants and their corresponding
isoforms are
expressed in human
macrophages, and suggests that this protein may be required by
HIV-1 for its
replication.[7]
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^Fisher DA, Smith JF, Pillar JS, St Denis SH, Cheng JB (Jul 1998). "Isolation and characterization of PDE8A, a novel human cAMP-specific phosphodiesterase". Biochem Biophys Res Commun. 246 (3): 570–577.
doi:
10.1006/bbrc.1998.8684.
PMID9618252.
Gamanuma M, Yuasa K, Sasaki T, et al. (2003). "Comparison of enzymatic characterization and gene organization of cyclic nucleotide phosphodiesterase 8 family in humans". Cell. Signal. 15 (6): 565–574.
doi:
10.1016/S0898-6568(02)00146-8.
PMID12681444.