PDE may refer to:

Mathematics

• Partial differential equation, differential equation involving partial derivatives (of a function of multiple variables)

Life sciences

• Phosphodiesterase, enzyme important in intracellular communication
• Pug dog encephalitis

Organizations

• The European Democratic Party (esp. in Spanish, French or Italian languages)

Technology and engineering

• Program development environment
• Pulse detonation engine, proposed substitute to the traditional jet engine

Philosophy

• Principle of double effect

Places

• Punta del Este

Other modes of abbreviation

• Polydichloric euthimal, fictional substance
• Pde (or Pde.), " Parade" (when serving as part of the proper name of a street or other way)
• Present Day English

This disambiguation page lists articles associated with the title PDE.
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