Polycomb group RING finger protein 1, PCGF1, also known as NSPC1 or RNF68 is a
RING finger domainprotein that in humans is encoded by the PCGF1gene.[5][6]
PCGF1 is a component defining the non-canonical
polycomb repressive complex 1.1 (ncPRC1) interacting with
RING1A/B,
RYBP,
BCOR and
KDM2B. [7] PCGF1-BCOR assembles via the ubiquitin-like RAWUL domain of PCGF1 and is recruited on the chromatin at
KDM2B sites.[8][9][10] Within the PRC1-like complex, PCGF1 regulates
RING1B ubiquitin ligase activity that catalyzes the
ubiquitination of Lys119 on histone H2A, [11] which then leads to recruitment of
PRC2 and H3K27me3 to effectively initiate a
polycomb domain and mediate gene repression. [12][13][14]
Polycomb group RING finger protein 1, PCGF1, also known as NSPC1 or RNF68 is a
RING finger domainprotein that in humans is encoded by the PCGF1gene.[5][6]
PCGF1 is a component defining the non-canonical
polycomb repressive complex 1.1 (ncPRC1) interacting with
RING1A/B,
RYBP,
BCOR and
KDM2B. [7] PCGF1-BCOR assembles via the ubiquitin-like RAWUL domain of PCGF1 and is recruited on the chromatin at
KDM2B sites.[8][9][10] Within the PRC1-like complex, PCGF1 regulates
RING1B ubiquitin ligase activity that catalyzes the
ubiquitination of Lys119 on histone H2A, [11] which then leads to recruitment of
PRC2 and H3K27me3 to effectively initiate a
polycomb domain and mediate gene repression. [12][13][14]