Protocadherin gamma-B7 is a
protein that in humans is encoded by the PCDHGB7gene.[5][6]
This gene is a member of the
protocadherin gamma gene cluster, one of three related clusters tandemly linked on
chromosome five. These gene clusters have an
immunoglobulin-like organization, suggesting that a novel mechanism may be involved in their regulation and expression. The gamma gene cluster includes 22 genes divided into 3 subfamilies. Subfamily A contains 12 genes, subfamily B contains 7 genes and 2
pseudogenes, and the more distantly related subfamily C contains 3 genes. The tandem array of 22 large, variable region
exons are followed by a constant region, containing 3 exons shared by all genes in the cluster. Each variable region exon encodes the extracellular region, which includes 6
cadherin ectodomains and a transmembrane region. The constant region exons encode the common cytoplasmic region. These neural cadherin-like cell adhesion proteins most likely play a critical role in the establishment and function of specific cell-cell connections in the
brain. Alternative splicing has been described for the gamma cluster genes.[6]
Nollet F, Kools P, van Roy F (2000). "Phylogenetic analysis of the cadherin superfamily allows identification of six major subfamilies besides several solitary members". J. Mol. Biol. 299 (3): 551–72.
doi:
10.1006/jmbi.2000.3777.
PMID10835267.
Protocadherin gamma-B7 is a
protein that in humans is encoded by the PCDHGB7gene.[5][6]
This gene is a member of the
protocadherin gamma gene cluster, one of three related clusters tandemly linked on
chromosome five. These gene clusters have an
immunoglobulin-like organization, suggesting that a novel mechanism may be involved in their regulation and expression. The gamma gene cluster includes 22 genes divided into 3 subfamilies. Subfamily A contains 12 genes, subfamily B contains 7 genes and 2
pseudogenes, and the more distantly related subfamily C contains 3 genes. The tandem array of 22 large, variable region
exons are followed by a constant region, containing 3 exons shared by all genes in the cluster. Each variable region exon encodes the extracellular region, which includes 6
cadherin ectodomains and a transmembrane region. The constant region exons encode the common cytoplasmic region. These neural cadherin-like cell adhesion proteins most likely play a critical role in the establishment and function of specific cell-cell connections in the
brain. Alternative splicing has been described for the gamma cluster genes.[6]
Nollet F, Kools P, van Roy F (2000). "Phylogenetic analysis of the cadherin superfamily allows identification of six major subfamilies besides several solitary members". J. Mol. Biol. 299 (3): 551–72.
doi:
10.1006/jmbi.2000.3777.
PMID10835267.