Protocadherin alpha-C2 is a
protein that in humans is encoded by the PCDHAC2gene.[5][6]
This gene is a member of the
protocadherin alpha gene cluster, one of three related gene clusters tandemly linked on
chromosome five that demonstrate an unusual genomic organization similar to that of
B-cell and
T-cell receptor gene clusters. The alpha gene cluster is composed of 15
cadherin superfamily genes related to the mouse CNR genes and consists of 13 highly similar and 2 more distantly related coding sequences. The tandem array of 15 N-terminal
exons, or variable exons, are followed by downstream C-terminal exons, or constant exons, which are shared by all genes in the cluster. The large, uninterrupted N-terminal exons each encode six cadherin ectodomains while the C-terminal exons encode the
cytoplasmic domain. These neural cadherin-like cell adhesion proteins are integral
plasma membrane proteins that most likely play a critical role in the establishment and function of specific cell-cell connections in the
brain. Alternative splicing has been observed and additional variants have been suggested but their full-length nature has yet to be determined.[6]
Nollet F, Kools P, van Roy F (2000). "Phylogenetic analysis of the cadherin superfamily allows identification of six major subfamilies besides several solitary members". J. Mol. Biol. 299 (3): 551–72.
doi:
10.1006/jmbi.2000.3777.
PMID10835267.
Sugino H, Hamada S, Yasuda R, et al. (2000). "Genomic organization of the family of CNR cadherin genes in mice and humans". Genomics. 63 (1): 75–87.
doi:
10.1006/geno.1999.6066.
PMID10662547.
Protocadherin alpha-C2 is a
protein that in humans is encoded by the PCDHAC2gene.[5][6]
This gene is a member of the
protocadherin alpha gene cluster, one of three related gene clusters tandemly linked on
chromosome five that demonstrate an unusual genomic organization similar to that of
B-cell and
T-cell receptor gene clusters. The alpha gene cluster is composed of 15
cadherin superfamily genes related to the mouse CNR genes and consists of 13 highly similar and 2 more distantly related coding sequences. The tandem array of 15 N-terminal
exons, or variable exons, are followed by downstream C-terminal exons, or constant exons, which are shared by all genes in the cluster. The large, uninterrupted N-terminal exons each encode six cadherin ectodomains while the C-terminal exons encode the
cytoplasmic domain. These neural cadherin-like cell adhesion proteins are integral
plasma membrane proteins that most likely play a critical role in the establishment and function of specific cell-cell connections in the
brain. Alternative splicing has been observed and additional variants have been suggested but their full-length nature has yet to be determined.[6]
Nollet F, Kools P, van Roy F (2000). "Phylogenetic analysis of the cadherin superfamily allows identification of six major subfamilies besides several solitary members". J. Mol. Biol. 299 (3): 551–72.
doi:
10.1006/jmbi.2000.3777.
PMID10835267.
Sugino H, Hamada S, Yasuda R, et al. (2000). "Genomic organization of the family of CNR cadherin genes in mice and humans". Genomics. 63 (1): 75–87.
doi:
10.1006/geno.1999.6066.
PMID10662547.