Poly(A) polymerase gamma is an
enzyme that in humans is encoded by the PAPOLGgene.[5]
This gene encodes a member of the
poly(A) polymerase family which catalyzes template-independent extension of the 3' end of a DNA/RNA strand. This enzyme shares 60% identity to the well characterized poly(A) polymerase II (PAPII) at the
amino acid level. These two enzymes have similar organization of structural and functional domains. This enzyme is exclusively localized in the nucleus and exhibits both nonspecific and CPSF (
cleavage and polyadenylation specificity factor)/AAUAAA-dependent
polyadenylation activity. This gene is located on
chromosome 2 in contrast to the PAPII gene, which is located on
chromosome 14.[5]
Poly(A) polymerase gamma is an
enzyme that in humans is encoded by the PAPOLGgene.[5]
This gene encodes a member of the
poly(A) polymerase family which catalyzes template-independent extension of the 3' end of a DNA/RNA strand. This enzyme shares 60% identity to the well characterized poly(A) polymerase II (PAPII) at the
amino acid level. These two enzymes have similar organization of structural and functional domains. This enzyme is exclusively localized in the nucleus and exhibits both nonspecific and CPSF (
cleavage and polyadenylation specificity factor)/AAUAAA-dependent
polyadenylation activity. This gene is located on
chromosome 2 in contrast to the PAPII gene, which is located on
chromosome 14.[5]