Peptidyl arginine deiminase, type I, also known as PADI1, is a
protein which in humans is encoded by the PADI1gene.[5][6]
This gene encodes a member of the
peptidyl arginine deiminase family of enzymes, which catalyze the post-translational
deimination of proteins by converting
arginine residues into
citrullines in the presence of calcium ions. The family members have distinct substrate specificities and tissue-specific expression patterns. The type I enzyme is involved in the late stages of
epidermal differentiation, where it deiminates
filaggrin and
keratin K1, which maintains hydration of the
stratum corneum, and hence the cutaneous barrier function. This enzyme may also play a role in
hair follicle formation. This gene exists in a cluster with four other
paralogous genes.[5]
Vossenaar ER, Zendman AJ, van Venrooij WJ, Pruijn GJ (2004). "PAD, a growing family of citrullinating enzymes: genes, features and involvement in disease". BioEssays. 25 (11): 1106–18.
doi:
10.1002/bies.10357.
PMID14579251.
S2CID22194514.
Chavanas S, Méchin MC, Nachat R, et al. (2006). "Peptidylarginine deiminases and deimination in biology and pathology: relevance to skin homeostasis". J. Dermatol. Sci. 44 (2): 63–72.
doi:
10.1016/j.jdermsci.2006.07.004.
PMID16973334.
Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4.
doi:
10.1016/0378-1119(94)90802-8.
PMID8125298.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56.
doi:
10.1016/S0378-1119(97)00411-3.
PMID9373149.
Chavanas S, Méchin MC, Takahara H, et al. (2004). "Comparative analysis of the mouse and human peptidylarginine deiminase gene clusters reveals highly conserved non-coding segments and a new human gene, PADI6". Gene. 330: 19–27.
doi:
10.1016/j.gene.2003.12.038.
PMID15087120.
Méchin MC, Enji M, Nachat R, et al. (2005). "The peptidylarginine deiminases expressed in human epidermis differ in their substrate specificities and subcellular locations". Cell. Mol. Life Sci. 62 (17): 1984–95.
doi:
10.1007/s00018-005-5196-y.
PMID16091842.
S2CID23610590.
Peptidyl arginine deiminase, type I, also known as PADI1, is a
protein which in humans is encoded by the PADI1gene.[5][6]
This gene encodes a member of the
peptidyl arginine deiminase family of enzymes, which catalyze the post-translational
deimination of proteins by converting
arginine residues into
citrullines in the presence of calcium ions. The family members have distinct substrate specificities and tissue-specific expression patterns. The type I enzyme is involved in the late stages of
epidermal differentiation, where it deiminates
filaggrin and
keratin K1, which maintains hydration of the
stratum corneum, and hence the cutaneous barrier function. This enzyme may also play a role in
hair follicle formation. This gene exists in a cluster with four other
paralogous genes.[5]
Vossenaar ER, Zendman AJ, van Venrooij WJ, Pruijn GJ (2004). "PAD, a growing family of citrullinating enzymes: genes, features and involvement in disease". BioEssays. 25 (11): 1106–18.
doi:
10.1002/bies.10357.
PMID14579251.
S2CID22194514.
Chavanas S, Méchin MC, Nachat R, et al. (2006). "Peptidylarginine deiminases and deimination in biology and pathology: relevance to skin homeostasis". J. Dermatol. Sci. 44 (2): 63–72.
doi:
10.1016/j.jdermsci.2006.07.004.
PMID16973334.
Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4.
doi:
10.1016/0378-1119(94)90802-8.
PMID8125298.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56.
doi:
10.1016/S0378-1119(97)00411-3.
PMID9373149.
Chavanas S, Méchin MC, Takahara H, et al. (2004). "Comparative analysis of the mouse and human peptidylarginine deiminase gene clusters reveals highly conserved non-coding segments and a new human gene, PADI6". Gene. 330: 19–27.
doi:
10.1016/j.gene.2003.12.038.
PMID15087120.
Méchin MC, Enji M, Nachat R, et al. (2005). "The peptidylarginine deiminases expressed in human epidermis differ in their substrate specificities and subcellular locations". Cell. Mol. Life Sci. 62 (17): 1984–95.
doi:
10.1007/s00018-005-5196-y.
PMID16091842.
S2CID23610590.