From Wikipedia, the free encyclopedia
CTNND1
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
Aliases CTNND1, CAS, CTNND, P120CAS, P120CTN, p120, p120(CAS), p120(CTN), catenin delta 1, BCDS2
External IDs OMIM: 601045; MGI: 105100; HomoloGene: 1017; GeneCards: CTNND1; OMA: CTNND1 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)
RefSeq (protein)
Location (UCSC) Chr 11: 57.75 – 57.82 Mb Chr 2: 84.43 – 84.48 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

p120 catenin, or simply p120, also called catenin delta-1, is a protein that in humans is encoded by the CTNND1 gene. [5]

Function

This gene encodes a member of the Armadillo protein family, which function in adhesion between cells and signal transduction. Multiple translation initiation codons and alternative splicing result in many different isoforms being translated. Not all of the full-length natures of the described transcript variants have been determined. [6]

Clinical significance

Immunohistochemistry for p120 has cytoplasmic staining in invasive lobular carcinoma (shown), but has membranous staining in invasive ductal carcinoma, thereby helping to distinguish these cancer types.

Either loss or cytoplasmic localization of p120 is a common feature in the progression of several types of carcinoma. [7]

Interactions

CTNND1 has been shown to interact with:

See also

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000198561Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000034101Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Reynolds AB, Jenkins NA, Gilbert DJ, Copeland NG, Shapiro DN, Wu J, Daniel JM (October 1996). "The gene encoding p120cas, a novel catenin, localizes on human chromosome 11q11 (CTNND) and mouse chromosome 2 (Catns)". Genomics. 31 (1): 127–9. doi: 10.1006/geno.1996.0020. PMID  8808291.
  6. ^ "Entrez Gene: CTNND1 catenin (cadherin-associated protein), delta 1".
  7. ^ Schackmann, R. C. J.; Tenhagen, M.; van de Ven, R. A. H.; Derksen, P. W. B. (2013). "p120-catenin in cancer - mechanisms, models and opportunities for intervention". Journal of Cell Science. 126 (16): 3515–3525. doi: 10.1242/jcs.134411. ISSN  0021-9533. PMID  23950111.
  8. ^ a b Hazan RB, Norton L (April 1998). "The epidermal growth factor receptor modulates the interaction of E-cadherin with the actin cytoskeleton". J. Biol. Chem. 273 (15): 9078–84. doi: 10.1074/jbc.273.15.9078. PMID  9535896.
  9. ^ Kucerová D, Sloncová E, Tuhácková Z, Vojtechová M, Sovová V (December 2001). "Expression and interaction of different catenins in colorectal carcinoma cells". Int. J. Mol. Med. 8 (6): 695–8. doi: 10.3892/ijmm.8.6.695. PMID  11712088.
  10. ^ a b c Piedra J, Miravet S, Castaño J, Pálmer HG, Heisterkamp N, García de Herreros A, Duñach M (2003). "p120 Catenin-associated Fer and Fyn tyrosine kinases regulate beta-catenin Tyr-142 phosphorylation and beta-catenin-alpha-catenin Interaction". Mol. Cell. Biol. 23 (7): 2287–97. doi: 10.1128/MCB.23.7.2287-2297.2003. PMC  150740. PMID  12640114.
  11. ^ Daniel JM, Reynolds AB (September 1995). "The tyrosine kinase substrate p120cas binds directly to E-cadherin but not to the adenomatous polyposis coli protein or alpha-catenin". Mol. Cell. Biol. 15 (9): 4819–24. doi: 10.1128/mcb.15.9.4819. PMC  230726. PMID  7651399.
  12. ^ Ireton RC, Davis MA, van Hengel J, Mariner DJ, Barnes K, Thoreson MA, Anastasiadis PZ, Matrisian L, Bundy LM, Sealy L, Gilbert B, van Roy F, Reynolds AB (2002). "A novel role for p120 catenin in E-cadherin function". J. Cell Biol. 159 (3): 465–76. doi: 10.1083/jcb.200205115. PMC  2173073. PMID  12427869.
  13. ^ Kinch MS, Clark GJ, Der CJ, Burridge K (1995). "Tyrosine phosphorylation regulates the adhesions of ras-transformed breast epithelia". J. Cell Biol. 130 (2): 461–71. doi: 10.1083/jcb.130.2.461. PMC  2199929. PMID  7542250.
  14. ^ Bonné S, Gilbert B, Hatzfeld M, Chen X, Green KJ, van Roy F (2003). "Defining desmosomal plakophilin-3 interactions". J. Cell Biol. 161 (2): 403–16. doi: 10.1083/jcb.200303036. PMC  2172904. PMID  12707304.
  15. ^ Shibamoto S, Hayakawa M, Takeuchi K, Hori T, Miyazawa K, Kitamura N, Johnson KR, Wheelock MJ, Matsuyoshi N, Takeichi M (1995). "Association of p120, a tyrosine kinase substrate, with E-cadherin/catenin complexes". J. Cell Biol. 128 (5): 949–57. doi: 10.1083/jcb.128.5.949. PMC  2120395. PMID  7876318.
  16. ^ Ohkubo T, Ozawa M (July 1999). "p120(ctn) binds to the membrane-proximal region of the E-cadherin cytoplasmic domain and is involved in modulation of adhesion activity". J. Biol. Chem. 274 (30): 21409–15. doi: 10.1074/jbc.274.30.21409. PMID  10409703.
  17. ^ Straub BK, Boda J, Kuhn C, Schnoelzer M, Korf U, Kempf T, Spring H, Hatzfeld M, Franke WW (December 2003). "A novel cell-cell junction system: the cortex adhaerens mosaic of lens fiber cells". J. Cell Sci. 116 (Pt 24): 4985–95. doi: 10.1242/jcs.00815. PMID  14625392.
  18. ^ Wahl JK, Kim YJ, Cullen JM, Johnson KR, Wheelock MJ (May 2003). "N-cadherin-catenin complexes form prior to cleavage of the proregion and transport to the plasma membrane". J. Biol. Chem. 278 (19): 17269–76. doi: 10.1074/jbc.M211452200. PMID  12604612.
  19. ^ Aho S, Rothenberger K, Uitto J (1999). "Human p120ctn catenin: tissue-specific expression of isoforms and molecular interactions with BP180/type XVII collagen". J. Cell. Biochem. 73 (3): 390–9. doi: 10.1002/(SICI)1097-4644(19990601)73:3<390::AID-JCB10>3.0.CO;2-1. PMID  10321838. S2CID  43899550.
  20. ^ a b Martinez MC, Ochiishi T, Majewski M, Kosik KS (2003). "Dual regulation of neuronal morphogenesis by a delta-catenin-cortactin complex and Rho". J. Cell Biol. 162 (1): 99–111. doi: 10.1083/jcb.200211025. PMC  2172717. PMID  12835311.
  21. ^ Li Y, Kufe D (February 2001). "The Human DF3/MUC1 carcinoma-associated antigen signals nuclear localization of the catenin p120(ctn)". Biochem. Biophys. Res. Commun. 281 (2): 440–3. doi: 10.1006/bbrc.2001.4383. PMID  11181067.
  22. ^ Lehtonen S, Lehtonen E, Kudlicka K, Holthöfer H, Farquhar MG (2004). "Nephrin forms a complex with adherens junction proteins and CASK in podocytes and in Madin-Darby canine kidney cells expressing nephrin". Am. J. Pathol. 165 (3): 923–36. doi: 10.1016/S0002-9440(10)63354-8. PMC  1618613. PMID  15331416.
  23. ^ Tanahashi H, Tabira T (February 1999). "Isolation of human delta-catenin and its binding specificity with presenilin 1". NeuroReport. 10 (3): 563–8. doi: 10.1097/00001756-199902250-00022. PMID  10208590.
  24. ^ Keilhack H, Hellman U, van Hengel J, van Roy F, Godovac-Zimmermann J, Böhmer FD (August 2000). "The protein-tyrosine phosphatase SHP-1 binds to and dephosphorylates p120 catenin". J. Biol. Chem. 275 (34): 26376–84. doi: 10.1074/jbc.M001315200. PMID  10835420.
  25. ^ Holsinger LJ, Ward K, Duffield B, Zachwieja J, Jallal B (October 2002). "The transmembrane receptor protein tyrosine phosphatase DEP1 interacts with p120(ctn)". Oncogene. 21 (46): 7067–76. doi: 10.1038/sj.onc.1205858. PMID  12370829.
  26. ^ Zondag GC, Reynolds AB, Moolenaar WH (April 2000). "Receptor protein-tyrosine phosphatase RPTPmu binds to and dephosphorylates the catenin p120(ctn)". J. Biol. Chem. 275 (15): 11264–9. doi: 10.1074/jbc.275.15.11264. PMID  10753936.
  27. ^ Ferber A, Yaen C, Sarmiento E, Martinez J (March 2002). "An octapeptide in the juxtamembrane domain of VE-cadherin is important for p120ctn binding and cell proliferation". Exp. Cell Res. 274 (1): 35–44. doi: 10.1006/excr.2001.5436. PMID  11855855.
  28. ^ Lampugnani MG, Corada M, Andriopoulou P, Esser S, Risau W, Dejana E (September 1997). "Cell confluence regulates tyrosine phosphorylation of adherens junction components in endothelial cells". J. Cell Sci. 110 (17): 2065–77. doi: 10.1242/jcs.110.17.2065. PMID  9378757.
  29. ^ Daniel JM, Reynolds AB (May 1999). "The catenin p120(ctn) interacts with Kaiso, a novel BTB/POZ domain zinc finger transcription factor". Mol. Cell. Biol. 19 (5): 3614–23. doi: 10.1128/mcb.19.5.3614. PMC  84161. PMID  10207085.

Further reading

External links

From Wikipedia, the free encyclopedia
CTNND1
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
Aliases CTNND1, CAS, CTNND, P120CAS, P120CTN, p120, p120(CAS), p120(CTN), catenin delta 1, BCDS2
External IDs OMIM: 601045; MGI: 105100; HomoloGene: 1017; GeneCards: CTNND1; OMA: CTNND1 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)
RefSeq (protein)
Location (UCSC) Chr 11: 57.75 – 57.82 Mb Chr 2: 84.43 – 84.48 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

p120 catenin, or simply p120, also called catenin delta-1, is a protein that in humans is encoded by the CTNND1 gene. [5]

Function

This gene encodes a member of the Armadillo protein family, which function in adhesion between cells and signal transduction. Multiple translation initiation codons and alternative splicing result in many different isoforms being translated. Not all of the full-length natures of the described transcript variants have been determined. [6]

Clinical significance

Immunohistochemistry for p120 has cytoplasmic staining in invasive lobular carcinoma (shown), but has membranous staining in invasive ductal carcinoma, thereby helping to distinguish these cancer types.

Either loss or cytoplasmic localization of p120 is a common feature in the progression of several types of carcinoma. [7]

Interactions

CTNND1 has been shown to interact with:

See also

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000198561Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000034101Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Reynolds AB, Jenkins NA, Gilbert DJ, Copeland NG, Shapiro DN, Wu J, Daniel JM (October 1996). "The gene encoding p120cas, a novel catenin, localizes on human chromosome 11q11 (CTNND) and mouse chromosome 2 (Catns)". Genomics. 31 (1): 127–9. doi: 10.1006/geno.1996.0020. PMID  8808291.
  6. ^ "Entrez Gene: CTNND1 catenin (cadherin-associated protein), delta 1".
  7. ^ Schackmann, R. C. J.; Tenhagen, M.; van de Ven, R. A. H.; Derksen, P. W. B. (2013). "p120-catenin in cancer - mechanisms, models and opportunities for intervention". Journal of Cell Science. 126 (16): 3515–3525. doi: 10.1242/jcs.134411. ISSN  0021-9533. PMID  23950111.
  8. ^ a b Hazan RB, Norton L (April 1998). "The epidermal growth factor receptor modulates the interaction of E-cadherin with the actin cytoskeleton". J. Biol. Chem. 273 (15): 9078–84. doi: 10.1074/jbc.273.15.9078. PMID  9535896.
  9. ^ Kucerová D, Sloncová E, Tuhácková Z, Vojtechová M, Sovová V (December 2001). "Expression and interaction of different catenins in colorectal carcinoma cells". Int. J. Mol. Med. 8 (6): 695–8. doi: 10.3892/ijmm.8.6.695. PMID  11712088.
  10. ^ a b c Piedra J, Miravet S, Castaño J, Pálmer HG, Heisterkamp N, García de Herreros A, Duñach M (2003). "p120 Catenin-associated Fer and Fyn tyrosine kinases regulate beta-catenin Tyr-142 phosphorylation and beta-catenin-alpha-catenin Interaction". Mol. Cell. Biol. 23 (7): 2287–97. doi: 10.1128/MCB.23.7.2287-2297.2003. PMC  150740. PMID  12640114.
  11. ^ Daniel JM, Reynolds AB (September 1995). "The tyrosine kinase substrate p120cas binds directly to E-cadherin but not to the adenomatous polyposis coli protein or alpha-catenin". Mol. Cell. Biol. 15 (9): 4819–24. doi: 10.1128/mcb.15.9.4819. PMC  230726. PMID  7651399.
  12. ^ Ireton RC, Davis MA, van Hengel J, Mariner DJ, Barnes K, Thoreson MA, Anastasiadis PZ, Matrisian L, Bundy LM, Sealy L, Gilbert B, van Roy F, Reynolds AB (2002). "A novel role for p120 catenin in E-cadherin function". J. Cell Biol. 159 (3): 465–76. doi: 10.1083/jcb.200205115. PMC  2173073. PMID  12427869.
  13. ^ Kinch MS, Clark GJ, Der CJ, Burridge K (1995). "Tyrosine phosphorylation regulates the adhesions of ras-transformed breast epithelia". J. Cell Biol. 130 (2): 461–71. doi: 10.1083/jcb.130.2.461. PMC  2199929. PMID  7542250.
  14. ^ Bonné S, Gilbert B, Hatzfeld M, Chen X, Green KJ, van Roy F (2003). "Defining desmosomal plakophilin-3 interactions". J. Cell Biol. 161 (2): 403–16. doi: 10.1083/jcb.200303036. PMC  2172904. PMID  12707304.
  15. ^ Shibamoto S, Hayakawa M, Takeuchi K, Hori T, Miyazawa K, Kitamura N, Johnson KR, Wheelock MJ, Matsuyoshi N, Takeichi M (1995). "Association of p120, a tyrosine kinase substrate, with E-cadherin/catenin complexes". J. Cell Biol. 128 (5): 949–57. doi: 10.1083/jcb.128.5.949. PMC  2120395. PMID  7876318.
  16. ^ Ohkubo T, Ozawa M (July 1999). "p120(ctn) binds to the membrane-proximal region of the E-cadherin cytoplasmic domain and is involved in modulation of adhesion activity". J. Biol. Chem. 274 (30): 21409–15. doi: 10.1074/jbc.274.30.21409. PMID  10409703.
  17. ^ Straub BK, Boda J, Kuhn C, Schnoelzer M, Korf U, Kempf T, Spring H, Hatzfeld M, Franke WW (December 2003). "A novel cell-cell junction system: the cortex adhaerens mosaic of lens fiber cells". J. Cell Sci. 116 (Pt 24): 4985–95. doi: 10.1242/jcs.00815. PMID  14625392.
  18. ^ Wahl JK, Kim YJ, Cullen JM, Johnson KR, Wheelock MJ (May 2003). "N-cadherin-catenin complexes form prior to cleavage of the proregion and transport to the plasma membrane". J. Biol. Chem. 278 (19): 17269–76. doi: 10.1074/jbc.M211452200. PMID  12604612.
  19. ^ Aho S, Rothenberger K, Uitto J (1999). "Human p120ctn catenin: tissue-specific expression of isoforms and molecular interactions with BP180/type XVII collagen". J. Cell. Biochem. 73 (3): 390–9. doi: 10.1002/(SICI)1097-4644(19990601)73:3<390::AID-JCB10>3.0.CO;2-1. PMID  10321838. S2CID  43899550.
  20. ^ a b Martinez MC, Ochiishi T, Majewski M, Kosik KS (2003). "Dual regulation of neuronal morphogenesis by a delta-catenin-cortactin complex and Rho". J. Cell Biol. 162 (1): 99–111. doi: 10.1083/jcb.200211025. PMC  2172717. PMID  12835311.
  21. ^ Li Y, Kufe D (February 2001). "The Human DF3/MUC1 carcinoma-associated antigen signals nuclear localization of the catenin p120(ctn)". Biochem. Biophys. Res. Commun. 281 (2): 440–3. doi: 10.1006/bbrc.2001.4383. PMID  11181067.
  22. ^ Lehtonen S, Lehtonen E, Kudlicka K, Holthöfer H, Farquhar MG (2004). "Nephrin forms a complex with adherens junction proteins and CASK in podocytes and in Madin-Darby canine kidney cells expressing nephrin". Am. J. Pathol. 165 (3): 923–36. doi: 10.1016/S0002-9440(10)63354-8. PMC  1618613. PMID  15331416.
  23. ^ Tanahashi H, Tabira T (February 1999). "Isolation of human delta-catenin and its binding specificity with presenilin 1". NeuroReport. 10 (3): 563–8. doi: 10.1097/00001756-199902250-00022. PMID  10208590.
  24. ^ Keilhack H, Hellman U, van Hengel J, van Roy F, Godovac-Zimmermann J, Böhmer FD (August 2000). "The protein-tyrosine phosphatase SHP-1 binds to and dephosphorylates p120 catenin". J. Biol. Chem. 275 (34): 26376–84. doi: 10.1074/jbc.M001315200. PMID  10835420.
  25. ^ Holsinger LJ, Ward K, Duffield B, Zachwieja J, Jallal B (October 2002). "The transmembrane receptor protein tyrosine phosphatase DEP1 interacts with p120(ctn)". Oncogene. 21 (46): 7067–76. doi: 10.1038/sj.onc.1205858. PMID  12370829.
  26. ^ Zondag GC, Reynolds AB, Moolenaar WH (April 2000). "Receptor protein-tyrosine phosphatase RPTPmu binds to and dephosphorylates the catenin p120(ctn)". J. Biol. Chem. 275 (15): 11264–9. doi: 10.1074/jbc.275.15.11264. PMID  10753936.
  27. ^ Ferber A, Yaen C, Sarmiento E, Martinez J (March 2002). "An octapeptide in the juxtamembrane domain of VE-cadherin is important for p120ctn binding and cell proliferation". Exp. Cell Res. 274 (1): 35–44. doi: 10.1006/excr.2001.5436. PMID  11855855.
  28. ^ Lampugnani MG, Corada M, Andriopoulou P, Esser S, Risau W, Dejana E (September 1997). "Cell confluence regulates tyrosine phosphorylation of adherens junction components in endothelial cells". J. Cell Sci. 110 (17): 2065–77. doi: 10.1242/jcs.110.17.2065. PMID  9378757.
  29. ^ Daniel JM, Reynolds AB (May 1999). "The catenin p120(ctn) interacts with Kaiso, a novel BTB/POZ domain zinc finger transcription factor". Mol. Cell. Biol. 19 (5): 3614–23. doi: 10.1128/mcb.19.5.3614. PMC  84161. PMID  10207085.

Further reading

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