p120 catenin, or simply p120, also called catenin delta-1, is a
protein that in humans is encoded by the CTNND1gene.[5]
Function
This gene encodes a member of the Armadillo protein family, which function in adhesion between cells and
signal transduction. Multiple translation initiation codons and
alternative splicing result in many different isoforms being translated. Not all of the full-length natures of the described transcript variants have been determined.[6]
Clinical significance
Either loss or cytoplasmic localization of p120 is a common feature in the progression of several types of
carcinoma.[7]
^Kucerová D, Sloncová E, Tuhácková Z, Vojtechová M, Sovová V (December 2001). "Expression and interaction of different catenins in colorectal carcinoma cells". Int. J. Mol. Med. 8 (6): 695–8.
doi:
10.3892/ijmm.8.6.695.
PMID11712088.
^Li Y, Kufe D (February 2001). "The Human DF3/MUC1 carcinoma-associated antigen signals nuclear localization of the catenin p120(ctn)". Biochem. Biophys. Res. Commun. 281 (2): 440–3.
doi:
10.1006/bbrc.2001.4383.
PMID11181067.
^Tanahashi H, Tabira T (February 1999). "Isolation of human delta-catenin and its binding specificity with presenilin 1". NeuroReport. 10 (3): 563–8.
doi:
10.1097/00001756-199902250-00022.
PMID10208590.
^Ferber A, Yaen C, Sarmiento E, Martinez J (March 2002). "An octapeptide in the juxtamembrane domain of VE-cadherin is important for p120ctn binding and cell proliferation". Exp. Cell Res. 274 (1): 35–44.
doi:
10.1006/excr.2001.5436.
PMID11855855.
^Lampugnani MG, Corada M, Andriopoulou P, Esser S, Risau W, Dejana E (September 1997). "Cell confluence regulates tyrosine phosphorylation of adherens junction components in endothelial cells". J. Cell Sci. 110 (17): 2065–77.
doi:
10.1242/jcs.110.17.2065.
PMID9378757.
Thoreson MA, Reynolds AB (2003). "Altered expression of the catenin p120 in human cancer: implications for tumor progression". Differentiation. 70 (9–10): 583–9.
doi:
10.1046/j.1432-0436.2002.700911.x.
PMID12492499.
Reynolds AB, Carnahan RH (2005). "Regulation of cadherin stability and turnover by p120ctn: implications in disease and cancer". Semin. Cell Dev. Biol. 15 (6): 657–63.
doi:
10.1016/j.semcdb.2004.09.003.
PMID15561585.
Keirsebilck A, Bonné S, Staes K, van Hengel J, Nollet F, Reynolds A, van Roy F (1998). "Molecular cloning of the human p120ctn catenin gene (CTNND1): expression of multiple alternatively spliced isoforms". Genomics. 50 (2): 129–46.
doi:
10.1006/geno.1998.5325.
PMID9653641.
p120 catenin, or simply p120, also called catenin delta-1, is a
protein that in humans is encoded by the CTNND1gene.[5]
Function
This gene encodes a member of the Armadillo protein family, which function in adhesion between cells and
signal transduction. Multiple translation initiation codons and
alternative splicing result in many different isoforms being translated. Not all of the full-length natures of the described transcript variants have been determined.[6]
Clinical significance
Either loss or cytoplasmic localization of p120 is a common feature in the progression of several types of
carcinoma.[7]
^Kucerová D, Sloncová E, Tuhácková Z, Vojtechová M, Sovová V (December 2001). "Expression and interaction of different catenins in colorectal carcinoma cells". Int. J. Mol. Med. 8 (6): 695–8.
doi:
10.3892/ijmm.8.6.695.
PMID11712088.
^Li Y, Kufe D (February 2001). "The Human DF3/MUC1 carcinoma-associated antigen signals nuclear localization of the catenin p120(ctn)". Biochem. Biophys. Res. Commun. 281 (2): 440–3.
doi:
10.1006/bbrc.2001.4383.
PMID11181067.
^Tanahashi H, Tabira T (February 1999). "Isolation of human delta-catenin and its binding specificity with presenilin 1". NeuroReport. 10 (3): 563–8.
doi:
10.1097/00001756-199902250-00022.
PMID10208590.
^Ferber A, Yaen C, Sarmiento E, Martinez J (March 2002). "An octapeptide in the juxtamembrane domain of VE-cadherin is important for p120ctn binding and cell proliferation". Exp. Cell Res. 274 (1): 35–44.
doi:
10.1006/excr.2001.5436.
PMID11855855.
^Lampugnani MG, Corada M, Andriopoulou P, Esser S, Risau W, Dejana E (September 1997). "Cell confluence regulates tyrosine phosphorylation of adherens junction components in endothelial cells". J. Cell Sci. 110 (17): 2065–77.
doi:
10.1242/jcs.110.17.2065.
PMID9378757.
Thoreson MA, Reynolds AB (2003). "Altered expression of the catenin p120 in human cancer: implications for tumor progression". Differentiation. 70 (9–10): 583–9.
doi:
10.1046/j.1432-0436.2002.700911.x.
PMID12492499.
Reynolds AB, Carnahan RH (2005). "Regulation of cadherin stability and turnover by p120ctn: implications in disease and cancer". Semin. Cell Dev. Biol. 15 (6): 657–63.
doi:
10.1016/j.semcdb.2004.09.003.
PMID15561585.
Keirsebilck A, Bonné S, Staes K, van Hengel J, Nollet F, Reynolds A, van Roy F (1998). "Molecular cloning of the human p120ctn catenin gene (CTNND1): expression of multiple alternatively spliced isoforms". Genomics. 50 (2): 129–46.
doi:
10.1006/geno.1998.5325.
PMID9653641.