Oxepanoprolinamides are a class of antibiotics. They include iboxamycin. [1] These drugs are fully synthetic. The molecules contain the aminooctose component of clindamycin. They were developed by Andrew G. Myers and Yury S. Polikanov. [1] The structure contains an oxepane (a seven-membered ring compound with oxygen) and a proline, with an amide group that increases rigidity. [2]
Oxepanoprolinamides function by insertion into bacterial ribosomes. They overcome a type of antibiotic resistance to clindamycin based on Erm and Cfr ribosomal RNA methyltransferase enzymes. [1] [3] [4]
Oxepanoprolinamides are a class of antibiotics. They include iboxamycin. [1] These drugs are fully synthetic. The molecules contain the aminooctose component of clindamycin. They were developed by Andrew G. Myers and Yury S. Polikanov. [1] The structure contains an oxepane (a seven-membered ring compound with oxygen) and a proline, with an amide group that increases rigidity. [2]
Oxepanoprolinamides function by insertion into bacterial ribosomes. They overcome a type of antibiotic resistance to clindamycin based on Erm and Cfr ribosomal RNA methyltransferase enzymes. [1] [3] [4]