Okello (also spelled Okelo) is a common surname of the Luo and Ateker peoples of Uganda, Kenya and Sudan. It may refer to:

• Okello Oculi (born 1942), Ugandan novelist and poet
• Allan Okello (born 2000), Ugandan footballer
• David Okello (born 1986), Kenyan footballer
• Emmy Okello (born 1977), Ugandan consultant physician
• Galdino Moro Okello (born 1940), Ugandan judge
• James Okello (born 1990), Ugandan basketball player
• John Okello (1937–1971), Ugandan-born leader of the Zanzibar revolution
• Noble Okello (born 2000), Canadian soccer player
• Tito Okello (1914–1996), former head of state of Uganda
• Bazilio Olara-Okello (1929–1990), former head of state of Uganda
• Henry Oryem Okello (born 1960), Ugandan politician

• Okello, a character in the 1972 film Aguirre, the Wrath of God

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