Off the Rails may refer to:

• Off the Rails (TV series), an Irish fashion magazine show
• Off the Rails (New Zealand TV series), a New Zealand TV show presented by Marcus Lush
• Off the Rails, a Railway Series book about Gordon the Big Engine
• Thrillville: Off the Rails, a theme park simulation video game
• Off the Rails (play), an adaptation of Shakespeare's Measure for Measure from a Native American perspective by Randy Reinholz
• Off the Rails (1921 film), a German silent drama film
• Off the Rails (2016 film), an American documentary film about Darius McCollum
• Off the Rails (2021 film), a British comedy-drama film

This disambiguation page lists articles associated with the title Off the Rails.
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