| OR6A2 | |||||||||||||||||||||||||||||||||||||||||||||||||||
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| Identifiers | |||||||||||||||||||||||||||||||||||||||||||||||||||
| Aliases | OR6A2, I7, OR11-55, OR6A1, OR6A2P, olfactory receptor family 6 subfamily A member 2 | ||||||||||||||||||||||||||||||||||||||||||||||||||
| External IDs | OMIM: 608495; MGI: 97432; HomoloGene: 2743; GeneCards: OR6A2; OMA: OR6A2 - orthologs | ||||||||||||||||||||||||||||||||||||||||||||||||||
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| Wikidata | |||||||||||||||||||||||||||||||||||||||||||||||||||
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Olfactory receptor 6A2 is a protein that in humans is encoded by the OR6A2 gene. [5] It is Class II ( tetrapod-specific) olfactory receptor and a rhodopsin-like receptor.
Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitters and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. [5]
Variation in the OR6A2 gene has been identified as a likely cause of why some people enjoy the smell and taste of coriander (also known as cilantro) [6] while others have exactly the opposite reaction to the point of repulsion. Depending on ancestry, somewhere between 3% and 21% of the population associate it with unpleasant taste, including a combination of soap and vomit, or say that it is similar to the foul smelling odor emitted by stinkbugs. This is due to the presence of aldehyde chemicals, [7] which are present in soap, various detergents, coriander, and several species of stinkbugs.[ citation needed]
- ^ a b c GRCh38: Ensembl release 89: ENSG00000184933 – Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000070417 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ a b "Entrez Gene: OR6A2 olfactory receptor, family 6, subfamily A, member 2".
- ^ Eriksson N; Wu S; Chuong BD; et al. (29 November 2012). "A genetic variant near olfactory receptor genes influences cilantro preference". Flavour. 1. arXiv: 1209.2096. doi: 10.1186/2044-7248-1-22. S2CID 199627.
- ^ Callaway E (September 2012). "Soapy taste of coriander linked to genetic variants". Nature. doi: 10.1038/nature.2012.11398. S2CID 87980895.
- Buettner JA, Glusman G, Ben-Arie N, et al. (1998). "Organization and evolution of olfactory receptor genes on human chromosome 11". Genomics. 53 (1): 56–68. doi: 10.1006/geno.1998.5422. PMID 9787077.
- Lane RP, Cutforth T, Young J, et al. (2001). "Genomic analysis of orthologous mouse and human olfactory receptor loci". Proc. Natl. Acad. Sci. U.S.A. 98 (13): 7390–5. Bibcode: 2001PNAS...98.7390L. doi: 10.1073/pnas.131215398. PMC 34679. PMID 11416212.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode: 2002PNAS...9916899M. doi: 10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Malnic B, Godfrey PA, Buck LB (2004). "The human olfactory receptor gene family". Proc. Natl. Acad. Sci. U.S.A. 101 (8): 2584–9. Bibcode: 2004PNAS..101.2584M. doi: 10.1073/pnas.0307882100. PMC 356993. PMID 14983052.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi: 10.1101/gr.2596504. PMC 528928. PMID 15489334.
- OR6A2+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
 | This transmembrane receptor-related article is a stub. You can help Wikipedia by expanding it. |
| OR6A2 | |||||||||||||||||||||||||||||||||||||||||||||||||||
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| Identifiers | |||||||||||||||||||||||||||||||||||||||||||||||||||
| Aliases | OR6A2, I7, OR11-55, OR6A1, OR6A2P, olfactory receptor family 6 subfamily A member 2 | ||||||||||||||||||||||||||||||||||||||||||||||||||
| External IDs | OMIM: 608495; MGI: 97432; HomoloGene: 2743; GeneCards: OR6A2; OMA: OR6A2 - orthologs | ||||||||||||||||||||||||||||||||||||||||||||||||||
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| Wikidata | |||||||||||||||||||||||||||||||||||||||||||||||||||
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Olfactory receptor 6A2 is a protein that in humans is encoded by the OR6A2 gene. [5] It is Class II ( tetrapod-specific) olfactory receptor and a rhodopsin-like receptor.
Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitters and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. [5]
Variation in the OR6A2 gene has been identified as a likely cause of why some people enjoy the smell and taste of coriander (also known as cilantro) [6] while others have exactly the opposite reaction to the point of repulsion. Depending on ancestry, somewhere between 3% and 21% of the population associate it with unpleasant taste, including a combination of soap and vomit, or say that it is similar to the foul smelling odor emitted by stinkbugs. This is due to the presence of aldehyde chemicals, [7] which are present in soap, various detergents, coriander, and several species of stinkbugs.[ citation needed]
- ^ a b c GRCh38: Ensembl release 89: ENSG00000184933 – Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000070417 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ a b "Entrez Gene: OR6A2 olfactory receptor, family 6, subfamily A, member 2".
- ^ Eriksson N; Wu S; Chuong BD; et al. (29 November 2012). "A genetic variant near olfactory receptor genes influences cilantro preference". Flavour. 1. arXiv: 1209.2096. doi: 10.1186/2044-7248-1-22. S2CID 199627.
- ^ Callaway E (September 2012). "Soapy taste of coriander linked to genetic variants". Nature. doi: 10.1038/nature.2012.11398. S2CID 87980895.
- Buettner JA, Glusman G, Ben-Arie N, et al. (1998). "Organization and evolution of olfactory receptor genes on human chromosome 11". Genomics. 53 (1): 56–68. doi: 10.1006/geno.1998.5422. PMID 9787077.
- Lane RP, Cutforth T, Young J, et al. (2001). "Genomic analysis of orthologous mouse and human olfactory receptor loci". Proc. Natl. Acad. Sci. U.S.A. 98 (13): 7390–5. Bibcode: 2001PNAS...98.7390L. doi: 10.1073/pnas.131215398. PMC 34679. PMID 11416212.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode: 2002PNAS...9916899M. doi: 10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Malnic B, Godfrey PA, Buck LB (2004). "The human olfactory receptor gene family". Proc. Natl. Acad. Sci. U.S.A. 101 (8): 2584–9. Bibcode: 2004PNAS..101.2584M. doi: 10.1073/pnas.0307882100. PMC 356993. PMID 14983052.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi: 10.1101/gr.2596504. PMC 528928. PMID 15489334.
- OR6A2+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
|
| This transmembrane receptor-related article is a stub. You can help Wikipedia by expanding it. |