2'-5'-oligoadenylate synthetase 1 is an
enzyme that in humans is encoded by the OAS1gene.[5][6]
This gene encodes a member of the
2-5A synthetase family, which include essential proteins involved in the
innate immune response to viral infection.
The encoded protein is induced by
interferons and uses
adenosine triphosphate in 2'-specific
nucleotidyl transfer reactions to synthesize 2',5'-oligoadenylates (2-5As). These molecules activate latent
RNase L, which results in both viral and endogenous
RNA degradation and the inhibition of viral replication. The three known members of this gene family are located in a cluster on
chromosome 12. Hypomorphic mutations in this gene have been associated with host susceptibility to viral infection, while gain-of-function variants can cause
autoinflammatory immunodeficiency.[7] Alternatively spliced transcript variants encoding different isoforms have been described.[8]
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^Renault B, Hovnanian A, Bryce S, Chang JJ, Lau S, Sakuntabhai A, Monk S, Carter S, Ross CJ, Pang J, Twells R, Chamberlain S, Monaco AP, Strachan T, Kucherlapati R (Feb 1998). "A sequence-ready physical map of a region of 12q24.1". Genomics. 45 (2): 271–8.
doi:
10.1006/geno.1997.4888.
PMID9344649.
^Nechiporuk T, Nechiporuk A, Sahba S, Figueroa K, Shibata H, Chen XN, Korenberg JR, de Jong P, Pulst SM (Nov 1997). "A high-resolution PAC and BAC map of the SCA2 region". Genomics. 44 (3): 321–9.
doi:
10.1006/geno.1997.4886.
PMID9325053.
Wathelet MG, Szpirer J, Nols CB, et al. (1988). "Cloning and chromosomal location of human genes inducible by type I interferon". Somat. Cell Mol. Genet. 14 (5): 415–26.
doi:
10.1007/BF01534709.
PMID3175763.
S2CID42406993.
Shiojiri S, Fukunaga R, Ichii Y, Sokawa Y (1986). "Structure and expression of a cloned cDNA for human (2'-5')oligoadenylate synthetase". J. Biochem. 99 (5): 1455–64.
doi:
10.1093/oxfordjournals.jbchem.a135615.
PMID3754863.
Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4.
doi:
10.1016/0378-1119(94)90802-8.
PMID8125298.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56.
doi:
10.1016/S0378-1119(97)00411-3.
PMID9373149.
Hovnanian A, Rebouillat D, Mattei MG, et al. (1998). "The human 2',5'-oligoadenylate synthetase locus is composed of three distinct genes clustered on chromosome 12q24.2 encoding the 100-, 69-, and 40-kDa forms". Genomics. 52 (3): 267–77.
doi:
10.1006/geno.1998.5443.
PMID9790745.
2'-5'-oligoadenylate synthetase 1 is an
enzyme that in humans is encoded by the OAS1gene.[5][6]
This gene encodes a member of the
2-5A synthetase family, which include essential proteins involved in the
innate immune response to viral infection.
The encoded protein is induced by
interferons and uses
adenosine triphosphate in 2'-specific
nucleotidyl transfer reactions to synthesize 2',5'-oligoadenylates (2-5As). These molecules activate latent
RNase L, which results in both viral and endogenous
RNA degradation and the inhibition of viral replication. The three known members of this gene family are located in a cluster on
chromosome 12. Hypomorphic mutations in this gene have been associated with host susceptibility to viral infection, while gain-of-function variants can cause
autoinflammatory immunodeficiency.[7] Alternatively spliced transcript variants encoding different isoforms have been described.[8]
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^Renault B, Hovnanian A, Bryce S, Chang JJ, Lau S, Sakuntabhai A, Monk S, Carter S, Ross CJ, Pang J, Twells R, Chamberlain S, Monaco AP, Strachan T, Kucherlapati R (Feb 1998). "A sequence-ready physical map of a region of 12q24.1". Genomics. 45 (2): 271–8.
doi:
10.1006/geno.1997.4888.
PMID9344649.
^Nechiporuk T, Nechiporuk A, Sahba S, Figueroa K, Shibata H, Chen XN, Korenberg JR, de Jong P, Pulst SM (Nov 1997). "A high-resolution PAC and BAC map of the SCA2 region". Genomics. 44 (3): 321–9.
doi:
10.1006/geno.1997.4886.
PMID9325053.
Wathelet MG, Szpirer J, Nols CB, et al. (1988). "Cloning and chromosomal location of human genes inducible by type I interferon". Somat. Cell Mol. Genet. 14 (5): 415–26.
doi:
10.1007/BF01534709.
PMID3175763.
S2CID42406993.
Shiojiri S, Fukunaga R, Ichii Y, Sokawa Y (1986). "Structure and expression of a cloned cDNA for human (2'-5')oligoadenylate synthetase". J. Biochem. 99 (5): 1455–64.
doi:
10.1093/oxfordjournals.jbchem.a135615.
PMID3754863.
Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4.
doi:
10.1016/0378-1119(94)90802-8.
PMID8125298.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56.
doi:
10.1016/S0378-1119(97)00411-3.
PMID9373149.
Hovnanian A, Rebouillat D, Mattei MG, et al. (1998). "The human 2',5'-oligoadenylate synthetase locus is composed of three distinct genes clustered on chromosome 12q24.2 encoding the 100-, 69-, and 40-kDa forms". Genomics. 52 (3): 267–77.
doi:
10.1006/geno.1998.5443.
PMID9790745.