Nucleoplasmin family | |
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![]() Illustration of the structure of nucleoplasmin | |
Identifiers | |
Symbol | NPM |
InterPro | IPR004301 |
Nucleoplasmin, the first identified molecular chaperone [1] is a thermostable acidic protein with a pentameric structure. The protein was first isolated from Xenopus species [2] [3] [4]
The pentameric protein participates in various significant cellular activities like sperm chromatin remodeling, nucleosome assembly, genome stability, ribosome biogenesis, DNA duplication and transcriptional regulation. [4] [5] During the assembly of regular nucleosomal arrays, these nucleoplasmins transfer the DNA to them by binding to the histones. This reaction requires ATP. [2] [6] [7] [8]
Humans express three members of the nucleoplasmin family:
Nucleoplasmin family | |
---|---|
![]() Illustration of the structure of nucleoplasmin | |
Identifiers | |
Symbol | NPM |
InterPro | IPR004301 |
Nucleoplasmin, the first identified molecular chaperone [1] is a thermostable acidic protein with a pentameric structure. The protein was first isolated from Xenopus species [2] [3] [4]
The pentameric protein participates in various significant cellular activities like sperm chromatin remodeling, nucleosome assembly, genome stability, ribosome biogenesis, DNA duplication and transcriptional regulation. [4] [5] During the assembly of regular nucleosomal arrays, these nucleoplasmins transfer the DNA to them by binding to the histones. This reaction requires ATP. [2] [6] [7] [8]
Humans express three members of the nucleoplasmin family: