Non-ossifying fibroma | |
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Other names | Fibroxanthoma |
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X-ray of nonossifying fibroma of distal tibia. | |
Specialty |
Rheumatology
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A non-ossifying fibroma (NOF) is a benign bone tumor of the osteoclastic giant cell-rich tumor type. [1] It generally occurs in the metaphysis of long bones in children and adolescents. [2] Typically, there are no symptoms unless there is a fracture. [2] It can occur as part of a syndrome such as when multiple non-ossifying fibromas occur in neurofibromatosis, or Jaffe–Campanacci syndrome in combination with cafe-au-lait spots, mental retardation, hypogonadism, eye and cardiovascular abnormalities. [2]
Diagnosis is by X-ray or MRI, usually when investigating a person for something else. [2] Medical imaging typically shows a well defined radiolucent lesion, with a distinct multilocular appearance, sometimes looking like bubbles. [2] It is usually around 1–2 cm in size, but be as large as 7 cm. [3] They consist of foci consist of collagen rich connective tissue, fibroblasts, histiocytes and osteoclasts. [2] Usually no treatment is required. [1] Surgical curettage and bone grafting may be required if it is large. [3]
It is found in 30–40% of children and adolescents, but rare in adults as most have resolved by this time. [2] They do not become malignant. [2] It affects twice as many males as females. [2] A NOF was identified on the mandible of Qafzeh 9, an early anatomically modern human dated to 90–100 000 yrs B.P. [4]
Most people with non-ossifying fibroma have no symptoms. [1] If the tumor is large, there may be pain over the affected area, a pathological fracture, and the affected limb might not function properly. [1] It can occur as part of a syndrome such as when multiple non-ossifying fibromas occur in neurofibromatosis, or Jaffe–Campanacci syndrome in combination with cafe-au-lait spots, mental retardation, hypogonadism, eye and cardiovascular abnormalities. [2]
It is usually diagnosed by x-ray or MRI, when investigating another problem. [1] The tumor presents as a well defined radiolucent lesion, with a distinct multilocular appearance, sometimes looking like a "soap bubble". [5] If small and no symptoms, then biopsy is not needed. [1]
Non-ossifying fibroma | |
---|---|
Other names | Fibroxanthoma |
![]() | |
X-ray of nonossifying fibroma of distal tibia. | |
Specialty |
Rheumatology
![]() |
A non-ossifying fibroma (NOF) is a benign bone tumor of the osteoclastic giant cell-rich tumor type. [1] It generally occurs in the metaphysis of long bones in children and adolescents. [2] Typically, there are no symptoms unless there is a fracture. [2] It can occur as part of a syndrome such as when multiple non-ossifying fibromas occur in neurofibromatosis, or Jaffe–Campanacci syndrome in combination with cafe-au-lait spots, mental retardation, hypogonadism, eye and cardiovascular abnormalities. [2]
Diagnosis is by X-ray or MRI, usually when investigating a person for something else. [2] Medical imaging typically shows a well defined radiolucent lesion, with a distinct multilocular appearance, sometimes looking like bubbles. [2] It is usually around 1–2 cm in size, but be as large as 7 cm. [3] They consist of foci consist of collagen rich connective tissue, fibroblasts, histiocytes and osteoclasts. [2] Usually no treatment is required. [1] Surgical curettage and bone grafting may be required if it is large. [3]
It is found in 30–40% of children and adolescents, but rare in adults as most have resolved by this time. [2] They do not become malignant. [2] It affects twice as many males as females. [2] A NOF was identified on the mandible of Qafzeh 9, an early anatomically modern human dated to 90–100 000 yrs B.P. [4]
Most people with non-ossifying fibroma have no symptoms. [1] If the tumor is large, there may be pain over the affected area, a pathological fracture, and the affected limb might not function properly. [1] It can occur as part of a syndrome such as when multiple non-ossifying fibromas occur in neurofibromatosis, or Jaffe–Campanacci syndrome in combination with cafe-au-lait spots, mental retardation, hypogonadism, eye and cardiovascular abnormalities. [2]
It is usually diagnosed by x-ray or MRI, when investigating another problem. [1] The tumor presents as a well defined radiolucent lesion, with a distinct multilocular appearance, sometimes looking like a "soap bubble". [5] If small and no symptoms, then biopsy is not needed. [1]