Neil Brockdorff | |
---|---|
Born | Neil Alexander Steven Brockdorff 1958 (age 65–66) [3] |
Education | Hampstead School [3] |
Alma mater |
University of Sussex (BSc) University of Glasgow (PhD) [4] |
Awards | EMBO Member (1999) [1] |
Scientific career | |
Fields |
Developmental epigenetics X inactivation [2] |
Institutions | University of Oxford |
Thesis | The effect of oestradiol-17β on the ribonucleases and ribonuclease inhibitor of immature rat uterus (1985) |
Website |
www |
Neil Alexander Steven Brockdorff FRS FMedSci FRSB [5] (born 1958) is a Wellcome Trust Principal Research Fellow and professor in the department of biochemistry at the University of Oxford. [6] [7] Brockdorff's research investigates gene and genome regulation in mammalian development. [8] His interests are in the molecular basis of X-inactivation, the process that evolved in mammals to equalise X chromosome gene expression levels in XX females relative to XY males. [8]
Brockdorff was educated at Hampstead School, the University of Sussex (BSc) [3] and the University of Glasgow (PhD). [4]
X inactivation is an important model for understanding how epigenetic mechanisms, for example modification of DNA and histone proteins around which DNA is packaged, contribute to gene regulation in developmental biology. [8] [9] In earlier work Brockdorff demonstrated that an unusual functional RNA molecule, XIST, controls the X inactivation process. [10] [11] Building on this finding he has elucidated key steps in XIST gene regulation during early development, and has defined major pathways through which XIST RNA induces chromosome wide gene silencing. [8] [12] [13] [14]
Brockdorff is a member of the European Molecular Biology Organization (EMBO), a Fellow of the Royal Society (FRS), a Fellow of the Academy of Medical Sciences (FMedSci) and a Fellow of the Royal Society of Biology (FRSB).
“All text published under the heading 'Biography' on Fellow profile pages is available under Creative Commons Attribution 4.0 International License.” -- Royal Society Terms, conditions and policies at the Wayback Machine (archived 2016-11-11)
This article incorporates text available under the CC BY 4.0 license.
Neil Brockdorff | |
---|---|
Born | Neil Alexander Steven Brockdorff 1958 (age 65–66) [3] |
Education | Hampstead School [3] |
Alma mater |
University of Sussex (BSc) University of Glasgow (PhD) [4] |
Awards | EMBO Member (1999) [1] |
Scientific career | |
Fields |
Developmental epigenetics X inactivation [2] |
Institutions | University of Oxford |
Thesis | The effect of oestradiol-17β on the ribonucleases and ribonuclease inhibitor of immature rat uterus (1985) |
Website |
www |
Neil Alexander Steven Brockdorff FRS FMedSci FRSB [5] (born 1958) is a Wellcome Trust Principal Research Fellow and professor in the department of biochemistry at the University of Oxford. [6] [7] Brockdorff's research investigates gene and genome regulation in mammalian development. [8] His interests are in the molecular basis of X-inactivation, the process that evolved in mammals to equalise X chromosome gene expression levels in XX females relative to XY males. [8]
Brockdorff was educated at Hampstead School, the University of Sussex (BSc) [3] and the University of Glasgow (PhD). [4]
X inactivation is an important model for understanding how epigenetic mechanisms, for example modification of DNA and histone proteins around which DNA is packaged, contribute to gene regulation in developmental biology. [8] [9] In earlier work Brockdorff demonstrated that an unusual functional RNA molecule, XIST, controls the X inactivation process. [10] [11] Building on this finding he has elucidated key steps in XIST gene regulation during early development, and has defined major pathways through which XIST RNA induces chromosome wide gene silencing. [8] [12] [13] [14]
Brockdorff is a member of the European Molecular Biology Organization (EMBO), a Fellow of the Royal Society (FRS), a Fellow of the Academy of Medical Sciences (FMedSci) and a Fellow of the Royal Society of Biology (FRSB).
“All text published under the heading 'Biography' on Fellow profile pages is available under Creative Commons Attribution 4.0 International License.” -- Royal Society Terms, conditions and policies at the Wayback Machine (archived 2016-11-11)
This article incorporates text available under the CC BY 4.0 license.