From Wikipedia, the free encyclopedia
Protein-coding gene in the species Homo sapiens
NUMBL Available structures
PDB Ortholog search:
PDBe
RCSB List of PDB id codes
3F0W
Identifiers
Aliases
NUMBL , CAG3A, CTG3a, NBL, NUMB-R, NUMBLIKE, NUMBR, TNRC23, NUMB like, endocytic adaptor protein, NUMB like endocytic adaptor proteinExternal IDs
OMIM :
604018 ;
MGI :
894702 ;
HomoloGene :
68413 ;
GeneCards :
NUMBL ;
OMA :
NUMBL - orthologs
Wikidata
Numb-like protein is a
protein that in humans is encoded by the NUMBL
gene .
[5]
[6]
[7]
NUMBL has been shown to
interact with
MAP3K7IP2 .
[8]
^
a
b
c
GRCh38: Ensembl release 89: ENSG00000105245 –
Ensembl , May 2017
^
a
b
c
GRCm38: Ensembl release 89: ENSMUSG00000063160 –
Ensembl , May 2017
^
"Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
^
"Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
^ Margolis RL, Abraham MR, Gatchell SB, Li SH, Kidwai AS, Breschel TS, Stine OC, Callahan C, McInnis MG, Ross CA (Jul 1997). "cDNAs with long CAG trinucleotide repeats from human brain". Hum Genet . 100 (1): 114–22.
doi :
10.1007/s004390050476 .
PMID
9225980 .
S2CID
25999127 .
^ Salcini AE, Confalonieri S, Doria M, Santolini E, Tassi E, Minenkova O, Cesareni G, Pelicci PG, Di Fiore PP (Oct 1997).
"Binding specificity and in vivo targets of the EH domain, a novel protein-protein interaction module" . Genes Dev . 11 (17): 2239–49.
doi :
10.1101/gad.11.17.2239 .
PMC
275390 .
PMID
9303539 .
^
"Entrez Gene: NUMBL numb homolog (Drosophila)-like" .
^ Ma Q, Zhou Li, Shi Huili, Huo Keke (Jun 2008). "NUMBL interacts with TAB2 and inhibits TNFalpha and IL-1beta-induced NF-kappaB activation". Cell. Signal . 20 (6). England: 1044–51.
doi :
10.1016/j.cellsig.2008.01.015 .
ISSN
0898-6568 .
PMID
18299187 .
Wong WT, Schumacher C, Salcini AE, et al. (1995).
"A protein-binding domain, EH, identified in the receptor tyrosine kinase substrate Eps15 and conserved in evolution" . Proc. Natl. Acad. Sci. U.S.A . 92 (21): 9530–4.
Bibcode :
1995PNAS...92.9530W .
doi :
10.1073/pnas.92.21.9530 .
PMC
40835 .
PMID
7568168 .
Zhong W, Feder JN, Jiang MM, et al. (1996).
"Asymmetric localization of a mammalian numb homolog during mouse cortical neurogenesis" . Neuron . 17 (1): 43–53.
doi :
10.1016/S0896-6273(00)80279-2 .
PMID
8755477 .
Zhong W, Jiang MM, Weinmaster G, et al. (1997). "Differential expression of mammalian Numb, Numblike and Notch1 suggests distinct roles during mouse cortical neurogenesis". Development . 124 (10): 1887–97.
doi :
10.1242/dev.124.10.1887 .
PMID
9169836 .
Roncarati R, Sestan N, Scheinfeld MH, et al. (2002).
"The gamma-secretase-generated intracellular domain of beta-amyloid precursor protein binds Numb and inhibits Notch signaling" . Proc. Natl. Acad. Sci. U.S.A . 99 (10): 7102–7.
Bibcode :
2002PNAS...99.7102R .
doi :
10.1073/pnas.102192599 .
PMC
124535 .
PMID
12011466 .
Strausberg RL, Feingold EA, Grouse LH, et al. (2003).
"Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences" . Proc. Natl. Acad. Sci. U.S.A . 99 (26): 16899–903.
Bibcode :
2002PNAS...9916899M .
doi :
10.1073/pnas.242603899 .
PMC
139241 .
PMID
12477932 .
Jin J, Smith FD, Stark C, et al. (2004).
"Proteomic, functional, and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization" . Curr. Biol . 14 (16): 1436–50.
Bibcode :
2004CBio...14.1436J .
doi :
10.1016/j.cub.2004.07.051 .
PMID
15324660 .
Gerhard DS, Wagner L, Feingold EA, et al. (2004).
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)" . Genome Res . 14 (10B): 2121–7.
doi :
10.1101/gr.2596504 .
PMC
528928 .
PMID
15489334 .
Lim J, Hao T, Shaw C, et al. (2006).
"A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration" . Cell . 125 (4): 801–14.
doi :
10.1016/j.cell.2006.03.032 .
PMID
16713569 .
Olsen JV, Blagoev B, Gnad F, et al. (2006).
"Global, in vivo, and site-specific phosphorylation dynamics in signaling networks" . Cell . 127 (3): 635–48.
doi :
10.1016/j.cell.2006.09.026 .
PMID
17081983 .