ADP-sugar pyrophosphatase is an enzyme that in humans is encoded by the NUDT5 gene. [5] [6]
Nudix hydrolases, such as NUDT5, eliminate toxic nucleotide derivatives from the cell and regulate the levels of important signaling nucleotides and their metabolites (McLennan, 1999).[supplied by OMIM] [6]
References
- ^ a b c GRCh38: Ensembl release 89: ENSG00000165609 – Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000025817 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ McLennan AG (Aug 1999). "The MutT motif family of nucleotide phosphohydrolases in man and human pathogens (review)". Int J Mol Med. 4 (1): 79–89. doi: 10.3892/ijmm.4.1.79. PMID 10373642.
- ^ a b "Entrez Gene: NUDT5 nudix (nucleoside diphosphate linked moiety X)-type motif 5".
Further reading
- Rush J, Moritz A, Lee KA, et al. (2005). "Immunoaffinity profiling of tyrosine phosphorylation in cancer cells". Nat. Biotechnol. 23 (1): 94–101. doi: 10.1038/nbt1046. PMID 15592455. S2CID 7200157.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi: 10.1101/gr.2596504. PMC 528928. PMID 15489334.
- Ishibashi T, Hayakawa H, Sekiguchi M (2004). "A novel mechanism for preventing mutations caused by oxidation of guanine nucleotides". EMBO Rep. 4 (5): 479–83. doi: 10.1038/sj.embor.embor838. PMC 1319193. PMID 12717453.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode: 2002PNAS...9916899M. doi: 10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Zhang QH, Ye M, Wu XY, et al. (2001). "Cloning and Functional Analysis of cDNAs with Open Reading Frames for 300 Previously Undefined Genes Expressed in CD34+ Hematopoietic Stem/Progenitor Cells". Genome Res. 10 (10): 1546–60. doi: 10.1101/gr.140200. PMC 310934. PMID 11042152.
- Yang H, Slupska MM, Wei YF, et al. (2000). "Cloning and characterization of a new member of the Nudix hydrolases from human and mouse". J. Biol. Chem. 275 (12): 8844–53. doi: 10.1074/jbc.275.12.8844. PMID 10722730.
- Gasmi L, Cartwright JL, McLennan AG (2000). "Cloning, expression and characterization of YSA1H, a human adenosine 5'-diphosphosugar pyrophosphatase possessing a MutT motif". Biochem. J. 344 Pt 2 (Pt 2): 331–7. doi: 10.1042/0264-6021:3440331. PMC 1220648. PMID 10567213.
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 | This article on a gene on human chromosome 10 is a stub. You can help Wikipedia by expanding it. |
| NUDT5 | |||||||||||||||||||||||||||||||||||||||||||||||||||
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| Identifiers | |||||||||||||||||||||||||||||||||||||||||||||||||||
| Aliases | NUDT5, YSA1, YSA1H, YSAH1, hYSAH1, nudix hydrolase 5, hNUDT5 | ||||||||||||||||||||||||||||||||||||||||||||||||||
| External IDs | OMIM: 609230; MGI: 1858232; HomoloGene: 5388; GeneCards: NUDT5; OMA: NUDT5 - orthologs | ||||||||||||||||||||||||||||||||||||||||||||||||||
| EC number | 3.6.1.58 | ||||||||||||||||||||||||||||||||||||||||||||||||||
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ADP-sugar pyrophosphatase is an enzyme that in humans is encoded by the NUDT5 gene. [5] [6]
Nudix hydrolases, such as NUDT5, eliminate toxic nucleotide derivatives from the cell and regulate the levels of important signaling nucleotides and their metabolites (McLennan, 1999).[supplied by OMIM] [6]
References
- ^ a b c GRCh38: Ensembl release 89: ENSG00000165609 – Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000025817 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ McLennan AG (Aug 1999). "The MutT motif family of nucleotide phosphohydrolases in man and human pathogens (review)". Int J Mol Med. 4 (1): 79–89. doi: 10.3892/ijmm.4.1.79. PMID 10373642.
- ^ a b "Entrez Gene: NUDT5 nudix (nucleoside diphosphate linked moiety X)-type motif 5".
Further reading
- Rush J, Moritz A, Lee KA, et al. (2005). "Immunoaffinity profiling of tyrosine phosphorylation in cancer cells". Nat. Biotechnol. 23 (1): 94–101. doi: 10.1038/nbt1046. PMID 15592455. S2CID 7200157.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi: 10.1101/gr.2596504. PMC 528928. PMID 15489334.
- Ishibashi T, Hayakawa H, Sekiguchi M (2004). "A novel mechanism for preventing mutations caused by oxidation of guanine nucleotides". EMBO Rep. 4 (5): 479–83. doi: 10.1038/sj.embor.embor838. PMC 1319193. PMID 12717453.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode: 2002PNAS...9916899M. doi: 10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Zhang QH, Ye M, Wu XY, et al. (2001). "Cloning and Functional Analysis of cDNAs with Open Reading Frames for 300 Previously Undefined Genes Expressed in CD34+ Hematopoietic Stem/Progenitor Cells". Genome Res. 10 (10): 1546–60. doi: 10.1101/gr.140200. PMC 310934. PMID 11042152.
- Yang H, Slupska MM, Wei YF, et al. (2000). "Cloning and characterization of a new member of the Nudix hydrolases from human and mouse". J. Biol. Chem. 275 (12): 8844–53. doi: 10.1074/jbc.275.12.8844. PMID 10722730.
- Gasmi L, Cartwright JL, McLennan AG (2000). "Cloning, expression and characterization of YSA1H, a human adenosine 5'-diphosphosugar pyrophosphatase possessing a MutT motif". Biochem. J. 344 Pt 2 (Pt 2): 331–7. doi: 10.1042/0264-6021:3440331. PMC 1220648. PMID 10567213.
PDB gallery | |
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| This article on a gene on human chromosome 10 is a stub. You can help Wikipedia by expanding it. |