From Wikipedia, the free encyclopedia
Protein-coding gene in the species Homo sapiens
NUDT3
Identifiers
Aliases
NUDT3 , DIPP, DIPP-1, DIPP1, nudix hydrolase 3External IDs
OMIM :
609228 ;
MGI :
1928484 ;
HomoloGene :
31400 ;
GeneCards :
NUDT3 ;
OMA :
NUDT3 - orthologs
RNA expression pattern
Bgee
Human
Mouse (ortholog)
Top expressed in dorsal motor nucleus of vagus nerve inferior olivary nucleus postcentral gyrus Brodmann area 46 Brodmann area 10 middle frontal gyrus Region I of hippocampus proper lateral nuclear group of thalamus external globus pallidus entorhinal cortex
Top expressed in neural layer of retina perirhinal cortex entorhinal cortex CA3 field dentate gyrus of hippocampal formation granule cell primary visual cortex superior frontal gyrus central gray substance of midbrain cingulate gyrus primary motor cortex
More reference expression data
BioGPS
Gene ontology Molecular function
inositol-3-diphosphate-1,2,4,5,6-pentakisphosphate diphosphatase activity
inositol diphosphate tetrakisphosphate diphosphatase activity
inositol-3,5-bisdiphosphate-2,3,4,6-tetrakisphosphate 5-diphosphatase activity
hydrolase activity
diphosphoinositol-polyphosphate diphosphatase activity
inositol-5-diphosphate-1,2,3,4,6-pentakisphosphate diphosphatase activity
metal ion binding
inositol-1,5-bisdiphosphate-2,3,4,6-tetrakisphosphate 1-diphosphatase activity
inositol-1,5-bisdiphosphate-2,3,4,6-tetrakisphosphate 5-diphosphatase activity
magnesium ion binding
inositol-1-diphosphate-2,3,4,5,6-pentakisphosphate diphosphatase activity
inositol diphosphate pentakisphosphate diphosphatase activity
inositol bisdiphosphate tetrakisphosphate diphosphatase activity
endopolyphosphatase activity
bis(5'-adenosyl)-hexaphosphatase activity
bis(5'-adenosyl)-pentaphosphatase activity
m7G(5')pppN diphosphatase activity
Cellular component Biological process Sources:
Amigo /
QuickGO
Wikidata
Diphosphoinositol polyphosphate phosphohydrolase 1 is an
enzyme that in humans is encoded by the NUDT3
gene .
[5]
[6]
NUDT3 belongs to the MutT, or Nudix, protein family. Nudix proteins act as homeostatic checkpoints at important stages in nucleoside phosphate metabolic pathways, guarding against elevated levels of potentially dangerous intermediates, like 8-oxo-dGTP, which promotes AT-to-CG transversions (Safrany et al., 1998).[supplied by OMIM]
[6]
References
^
a
b
c
GRCh38: Ensembl release 89: ENSG00000272325 –
Ensembl , May 2017
^
a
b
c
GRCm38: Ensembl release 89: ENSMUSG00000024213 –
Ensembl , May 2017
^
"Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
^
"Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
^ Safrany ST, Caffrey JJ, Yang X, Bembenek ME, Moyer MB, Burkhart WA, Shears SB (Jan 1999).
"A novel context for the 'MutT' module, a guardian of cell integrity, in a diphosphoinositol polyphosphate phosphohydrolase" . EMBO J . 17 (22): 6599–607.
doi :
10.1093/emboj/17.22.6599 .
PMC
1171006 .
PMID
9822604 .
^
a
b
"Entrez Gene: NUDT3 nudix (nucleoside diphosphate linked moiety X)-type motif 3" .
Further reading
Safrany ST, Ingram SW, Cartwright JL, et al. (1999).
"The diadenosine hexaphosphate hydrolases from Schizosaccharomyces pombe and Saccharomyces cerevisiae are homologues of the human diphosphoinositol polyphosphate phosphohydrolase. Overlapping substrate specificities in a MutT-type protein" . J. Biol. Chem . 274 (31): 21735–40.
doi :
10.1074/jbc.274.31.21735 .
PMID
10419486 .
Yang X, Safrany ST, Shears SB (2000).
"Site-directed mutagenesis of diphosphoinositol polyphosphate phosphohydrolase, a dual specificity NUDT enzyme that attacks diadenosine polyphosphates and diphosphoinositol polyphosphates" . J. Biol. Chem . 274 (50): 35434–40.
doi :
10.1074/jbc.274.50.35434 .
PMID
10585413 .
Fisher DI, Safrany ST, Strike P, et al. (2003).
"Nudix hydrolases that degrade dinucleoside and diphosphoinositol polyphosphates also have 5-phosphoribosyl 1-pyrophosphate (PRPP) pyrophosphatase activity that generates the glycolytic activator ribose 1,5-bisphosphate" . J. Biol. Chem . 277 (49): 47313–7.
doi :
10.1074/jbc.M209795200 .
PMID
12370170 .
Strausberg RL, Feingold EA, Grouse LH, et al. (2003).
"Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences" . Proc. Natl. Acad. Sci. U.S.A . 99 (26): 16899–903.
Bibcode :
2002PNAS...9916899M .
doi :
10.1073/pnas.242603899 .
PMC
139241 .
PMID
12477932 .
Mungall AJ, Palmer SA, Sims SK, et al. (2003).
"The DNA sequence and analysis of human chromosome 6" . Nature . 425 (6960): 805–11.
Bibcode :
2003Natur.425..805M .
doi :
10.1038/nature02055 .
PMID
14574404 .
Gerhard DS, Wagner L, Feingold EA, et al. (2004).
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)" . Genome Res . 14 (10B): 2121–7.
doi :
10.1101/gr.2596504 .
PMC
528928 .
PMID
15489334 .
Stelzl U, Worm U, Lalowski M, et al. (2005). "A human protein-protein interaction network: a resource for annotating the proteome". Cell . 122 (6): 957–68.
doi :
10.1016/j.cell.2005.08.029 .
hdl :
11858/00-001M-0000-0010-8592-0 .
PMID
16169070 .
S2CID
8235923 .
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature . 437 (7062): 1173–8.
Bibcode :
2005Natur.437.1173R .
doi :
10.1038/nature04209 .
PMID
16189514 .
S2CID
4427026 .