NudC domain-containing protein 3 is a
protein that in humans is encoded by the NUDCD3gene.[5]
Function
The product of this gene functions to maintain the stability of
dynein intermediate chain. Depletion of this gene product results in aggregation and degradation of dynein intermediate chain, mislocalization of the dynein complex from
kinetochores,
spindle microtubules, and
spindle poles, and loss of
gamma-tubulin from spindle poles. The protein localizes to the
Golgi apparatus during
interphase, and levels of the protein increase after the
G1/S transition.[5]
NudC domain-containing protein 3 is a
protein that in humans is encoded by the NUDCD3gene.[5]
Function
The product of this gene functions to maintain the stability of
dynein intermediate chain. Depletion of this gene product results in aggregation and degradation of dynein intermediate chain, mislocalization of the dynein complex from
kinetochores,
spindle microtubules, and
spindle poles, and loss of
gamma-tubulin from spindle poles. The protein localizes to the
Golgi apparatus during
interphase, and levels of the protein increase after the
G1/S transition.[5]