(Redirected from
NRP2)
Neuropilin 2 (NRP2) is a protein that in humans is encoded by the NRP2 gene. [5] [6]
This gene encodes a member of the neuropilin family of receptor proteins. NRP2 is expressed by a wide variety of cell types. The transmembrane protein has been reported to bind to SEMA3C, SEMA3F, VEGF-A, VEGF-C, VEGF-D, TGFβ, integrins and ANGPTL4 to promote downstream signaling pathways. Consequently, NRP2 is known to play a role in cardiovascular development, axon guidance, tumorigenesis, inflammation and cardiovascular disease. [7] [8] [9] [10] Multiple transcript variants encoding distinct isoforms have been identified for this gene. [11]
References
- ^ a b c GRCh38: Ensembl release 89: ENSG00000118257 – Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000025969 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ Soker S, Takashima S, Miao HQ, Neufeld G, Klagsbrun M (March 1998). "Neuropilin-1 is expressed by endothelial and tumor cells as an isoform-specific receptor for vascular endothelial growth factor". Cell. 92 (6): 735–45. doi: 10.1016/S0092-8674(00)81402-6. PMID 9529250. S2CID 547080.
- ^ Chen H, Chédotal A, He Z, Goodman CS, Tessier-Lavigne M (September 1997). "Neuropilin-2, a novel member of the neuropilin family, is a high affinity receptor for the semaphorins Sema E and Sema IV but not Sema III". Neuron. 19 (3): 547–59. doi: 10.1016/S0896-6273(00)80371-2. PMID 9331348. S2CID 17985062.
- ^ Harman JL, Sayers J, Chapman C, Pellet-Many C (2020-07-21). "Emerging Roles for Neuropilin-2 in Cardiovascular Disease". International Journal of Molecular Sciences. 21 (14): 5154. doi: 10.3390/ijms21145154. PMC 7404143. PMID 32708258.
- ^ Kofler N, Simons M (May 2016). "The expanding role of neuropilin: regulation of transforming growth factor-β and platelet-derived growth factor signaling in the vasculature". Current Opinion in Hematology. 23 (3): 260–7. doi: 10.1097/MOH.0000000000000233. PMC 4957701. PMID 26849476.
- ^ Peng K, Bai Y, Zhu Q, Hu B, Xu Y (February 2019). "Targeting VEGF-neuropilin interactions: a promising antitumor strategy". Drug Discovery Today. 24 (2): 656–664. doi: 10.1016/j.drudis.2018.10.004. PMID 30315890. S2CID 52979538.
- ^ Kitsukawa T, Shimizu M, Sanbo M, Hirata T, Taniguchi M, Bekku Y, Yagi T, Fujisawa H (November 1997). "Neuropilin-semaphorin III/D-mediated chemorepulsive signals play a crucial role in peripheral nerve projection in mice". Neuron. 19 (5): 995–1005. doi: 10.1016/s0896-6273(00)80392-x. PMID 9390514. S2CID 17769318.
- ^ "Entrez Gene: NRP2 neuropilin 2".
Further reading
- Neufeld G, Cohen T, Gengrinovitch S, Poltorak Z (January 1999). "Vascular endothelial growth factor (VEGF) and its receptors". FASEB Journal. 13 (1): 9–22. doi: 10.1096/fasebj.13.1.9. PMID 9872925. S2CID 1151216.
- Kolodkin AL, Levengood DV, Rowe EG, Tai YT, Giger RJ, Ginty DD (August 1997). "Neuropilin is a semaphorin III receptor". Cell. 90 (4): 753–62. doi: 10.1016/S0092-8674(00)80535-8. PMID 9288754. S2CID 17268123.
- Giger RJ, Urquhart ER, Gillespie SK, Levengood DV, Ginty DD, Kolodkin AL (November 1998). "Neuropilin-2 is a receptor for semaphorin IV: insight into the structural basis of receptor function and specificity". Neuron. 21 (5): 1079–92. doi: 10.1016/S0896-6273(00)80625-X. PMID 9856463. S2CID 18445456.
- Chen H, He Z, Bagri A, Tessier-Lavigne M (December 1998). "Semaphorin-neuropilin interactions underlying sympathetic axon responses to class III semaphorins". Neuron. 21 (6): 1283–90. doi: 10.1016/S0896-6273(00)80648-0. PMID 9883722.
- Takahashi T, Nakamura F, Jin Z, Kalb RG, Strittmatter SM (October 1998). "Semaphorins A and E act as antagonists of neuropilin-1 and agonists of neuropilin-2 receptors". Nature Neuroscience. 1 (6): 487–93. doi: 10.1038/2203. PMID 10196546. S2CID 38320889.
- Rossignol M, Beggs AH, Pierce EA, Klagsbrun M (May 1999). "Human neuropilin-1 and neuropilin-2 map to 10p12 and 2q34, respectively". Genomics. 57 (3): 459–60. doi: 10.1006/geno.1999.5790. PMID 10329017.
- Tamagnone L, Artigiani S, Chen H, He Z, Ming GI, Song H, et al. (October 1999). "Plexins are a large family of receptors for transmembrane, secreted, and GPI-anchored semaphorins in vertebrates". Cell. 99 (1): 71–80. doi: 10.1016/S0092-8674(00)80063-X. PMID 10520995. S2CID 17386412.
- Gluzman-Poltorak Z, Cohen T, Herzog Y, Neufeld G (June 2000). "Neuropilin-2 is a receptor for the vascular endothelial growth factor (VEGF) forms VEGF-145 and VEGF-165 [corrected]". The Journal of Biological Chemistry. 275 (24): 18040–5. doi: 10.1074/jbc.M909259199. PMID 10748121.
- Handa A, Tokunaga T, Tsuchida T, Lee YH, Kijima H, Yamazaki H, et al. (August 2000). "Neuropilin-2 expression affects the increased vascularization and is a prognostic factor in osteosarcoma". International Journal of Oncology. 17 (2): 291–5. doi: 10.3892/ijo.17.2.291. PMID 10891538.
- Rossignol M, Gagnon ML, Klagsbrun M (December 2000). "Genomic organization of human neuropilin-1 and neuropilin-2 genes: identification and distribution of splice variants and soluble isoforms". Genomics. 70 (2): 211–22. doi: 10.1006/geno.2000.6381. PMID 11112349.
- Gluzman-Poltorak Z, Cohen T, Shibuya M, Neufeld G (June 2001). "Vascular endothelial growth factor receptor-1 and neuropilin-2 form complexes". The Journal of Biological Chemistry. 276 (22): 18688–94. doi: 10.1074/jbc.M006909200. PMID 11278319.
- Cohen T, Gluzman-Poltorak Z, Brodzky A, Meytal V, Sabo E, Misselevich I, et al. (June 2001). "Neuroendocrine cells along the digestive tract express neuropilin-2". Biochemical and Biophysical Research Communications. 284 (2): 395–403. doi: 10.1006/bbrc.2001.4958. PMID 11394892.
- Herzog Y, Kalcheim C, Kahane N, Reshef R, Neufeld G (November 2001). "Differential expression of neuropilin-1 and neuropilin-2 in arteries and veins". Mechanisms of Development. 109 (1): 115–9. doi: 10.1016/S0925-4773(01)00518-4. PMID 11677062. S2CID 18341197.
- Oh H, Takagi H, Otani A, Koyama S, Kemmochi S, Uemura A, Honda Y (January 2002). "Selective induction of neuropilin-1 by vascular endothelial growth factor (VEGF): a mechanism contributing to VEGF-induced angiogenesis". Proceedings of the National Academy of Sciences of the United States of America. 99 (1): 383–8. Bibcode: 2002PNAS...99..383O. doi: 10.1073/pnas.012074399. PMC 117569. PMID 11756651.
- Fakhari M, Pullirsch D, Abraham D, Paya K, Hofbauer R, Holzfeind P, et al. (January 2002). "Selective upregulation of vascular endothelial growth factor receptors neuropilin-1 and -2 in human neuroblastoma". Cancer. 94 (1): 258–63. doi: 10.1002/cncr.10177. PMID 11815985. S2CID 45773136.
- Cohen T, Herzog Y, Brodzky A, Greenson JK, Eldar S, Gluzman-Poltorak Z, et al. (September 2002). "Neuropilin-2 is a novel marker expressed in pancreatic islet cells and endocrine pancreatic tumours". The Journal of Pathology. 198 (1): 77–82. doi: 10.1002/path.1179. PMID 12210066. S2CID 24579823.
- Kawakami T, Tokunaga T, Hatanaka H, Kijima H, Yamazaki H, Abe Y, et al. (November 2002). "Neuropilin 1 and neuropilin 2 co-expression is significantly correlated with increased vascularity and poor prognosis in nonsmall cell lung carcinoma". Cancer. 95 (10): 2196–201. doi: 10.1002/cncr.10936. PMID 12412174. S2CID 28744286.
 | This article on a gene on human chromosome 2 is a stub. You can help Wikipedia by expanding it. |
(Redirected from
NRP2)
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| Aliases | NRP2, NP2, NPN2, PRO2714, VEGF165R2, neuropilin 2 | ||||||||||||||||||||||||||||||||||||||||||||||||||
| External IDs | OMIM: 602070; MGI: 1100492; HomoloGene: 2875; GeneCards: NRP2; OMA: NRP2 - orthologs | ||||||||||||||||||||||||||||||||||||||||||||||||||
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Neuropilin 2 (NRP2) is a protein that in humans is encoded by the NRP2 gene. [5] [6]
This gene encodes a member of the neuropilin family of receptor proteins. NRP2 is expressed by a wide variety of cell types. The transmembrane protein has been reported to bind to SEMA3C, SEMA3F, VEGF-A, VEGF-C, VEGF-D, TGFβ, integrins and ANGPTL4 to promote downstream signaling pathways. Consequently, NRP2 is known to play a role in cardiovascular development, axon guidance, tumorigenesis, inflammation and cardiovascular disease. [7] [8] [9] [10] Multiple transcript variants encoding distinct isoforms have been identified for this gene. [11]
References
- ^ a b c GRCh38: Ensembl release 89: ENSG00000118257 – Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000025969 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ Soker S, Takashima S, Miao HQ, Neufeld G, Klagsbrun M (March 1998). "Neuropilin-1 is expressed by endothelial and tumor cells as an isoform-specific receptor for vascular endothelial growth factor". Cell. 92 (6): 735–45. doi: 10.1016/S0092-8674(00)81402-6. PMID 9529250. S2CID 547080.
- ^ Chen H, Chédotal A, He Z, Goodman CS, Tessier-Lavigne M (September 1997). "Neuropilin-2, a novel member of the neuropilin family, is a high affinity receptor for the semaphorins Sema E and Sema IV but not Sema III". Neuron. 19 (3): 547–59. doi: 10.1016/S0896-6273(00)80371-2. PMID 9331348. S2CID 17985062.
- ^ Harman JL, Sayers J, Chapman C, Pellet-Many C (2020-07-21). "Emerging Roles for Neuropilin-2 in Cardiovascular Disease". International Journal of Molecular Sciences. 21 (14): 5154. doi: 10.3390/ijms21145154. PMC 7404143. PMID 32708258.
- ^ Kofler N, Simons M (May 2016). "The expanding role of neuropilin: regulation of transforming growth factor-β and platelet-derived growth factor signaling in the vasculature". Current Opinion in Hematology. 23 (3): 260–7. doi: 10.1097/MOH.0000000000000233. PMC 4957701. PMID 26849476.
- ^ Peng K, Bai Y, Zhu Q, Hu B, Xu Y (February 2019). "Targeting VEGF-neuropilin interactions: a promising antitumor strategy". Drug Discovery Today. 24 (2): 656–664. doi: 10.1016/j.drudis.2018.10.004. PMID 30315890. S2CID 52979538.
- ^ Kitsukawa T, Shimizu M, Sanbo M, Hirata T, Taniguchi M, Bekku Y, Yagi T, Fujisawa H (November 1997). "Neuropilin-semaphorin III/D-mediated chemorepulsive signals play a crucial role in peripheral nerve projection in mice". Neuron. 19 (5): 995–1005. doi: 10.1016/s0896-6273(00)80392-x. PMID 9390514. S2CID 17769318.
- ^ "Entrez Gene: NRP2 neuropilin 2".
Further reading
- Neufeld G, Cohen T, Gengrinovitch S, Poltorak Z (January 1999). "Vascular endothelial growth factor (VEGF) and its receptors". FASEB Journal. 13 (1): 9–22. doi: 10.1096/fasebj.13.1.9. PMID 9872925. S2CID 1151216.
- Kolodkin AL, Levengood DV, Rowe EG, Tai YT, Giger RJ, Ginty DD (August 1997). "Neuropilin is a semaphorin III receptor". Cell. 90 (4): 753–62. doi: 10.1016/S0092-8674(00)80535-8. PMID 9288754. S2CID 17268123.
- Giger RJ, Urquhart ER, Gillespie SK, Levengood DV, Ginty DD, Kolodkin AL (November 1998). "Neuropilin-2 is a receptor for semaphorin IV: insight into the structural basis of receptor function and specificity". Neuron. 21 (5): 1079–92. doi: 10.1016/S0896-6273(00)80625-X. PMID 9856463. S2CID 18445456.
- Chen H, He Z, Bagri A, Tessier-Lavigne M (December 1998). "Semaphorin-neuropilin interactions underlying sympathetic axon responses to class III semaphorins". Neuron. 21 (6): 1283–90. doi: 10.1016/S0896-6273(00)80648-0. PMID 9883722.
- Takahashi T, Nakamura F, Jin Z, Kalb RG, Strittmatter SM (October 1998). "Semaphorins A and E act as antagonists of neuropilin-1 and agonists of neuropilin-2 receptors". Nature Neuroscience. 1 (6): 487–93. doi: 10.1038/2203. PMID 10196546. S2CID 38320889.
- Rossignol M, Beggs AH, Pierce EA, Klagsbrun M (May 1999). "Human neuropilin-1 and neuropilin-2 map to 10p12 and 2q34, respectively". Genomics. 57 (3): 459–60. doi: 10.1006/geno.1999.5790. PMID 10329017.
- Tamagnone L, Artigiani S, Chen H, He Z, Ming GI, Song H, et al. (October 1999). "Plexins are a large family of receptors for transmembrane, secreted, and GPI-anchored semaphorins in vertebrates". Cell. 99 (1): 71–80. doi: 10.1016/S0092-8674(00)80063-X. PMID 10520995. S2CID 17386412.
- Gluzman-Poltorak Z, Cohen T, Herzog Y, Neufeld G (June 2000). "Neuropilin-2 is a receptor for the vascular endothelial growth factor (VEGF) forms VEGF-145 and VEGF-165 [corrected]". The Journal of Biological Chemistry. 275 (24): 18040–5. doi: 10.1074/jbc.M909259199. PMID 10748121.
- Handa A, Tokunaga T, Tsuchida T, Lee YH, Kijima H, Yamazaki H, et al. (August 2000). "Neuropilin-2 expression affects the increased vascularization and is a prognostic factor in osteosarcoma". International Journal of Oncology. 17 (2): 291–5. doi: 10.3892/ijo.17.2.291. PMID 10891538.
- Rossignol M, Gagnon ML, Klagsbrun M (December 2000). "Genomic organization of human neuropilin-1 and neuropilin-2 genes: identification and distribution of splice variants and soluble isoforms". Genomics. 70 (2): 211–22. doi: 10.1006/geno.2000.6381. PMID 11112349.
- Gluzman-Poltorak Z, Cohen T, Shibuya M, Neufeld G (June 2001). "Vascular endothelial growth factor receptor-1 and neuropilin-2 form complexes". The Journal of Biological Chemistry. 276 (22): 18688–94. doi: 10.1074/jbc.M006909200. PMID 11278319.
- Cohen T, Gluzman-Poltorak Z, Brodzky A, Meytal V, Sabo E, Misselevich I, et al. (June 2001). "Neuroendocrine cells along the digestive tract express neuropilin-2". Biochemical and Biophysical Research Communications. 284 (2): 395–403. doi: 10.1006/bbrc.2001.4958. PMID 11394892.
- Herzog Y, Kalcheim C, Kahane N, Reshef R, Neufeld G (November 2001). "Differential expression of neuropilin-1 and neuropilin-2 in arteries and veins". Mechanisms of Development. 109 (1): 115–9. doi: 10.1016/S0925-4773(01)00518-4. PMID 11677062. S2CID 18341197.
- Oh H, Takagi H, Otani A, Koyama S, Kemmochi S, Uemura A, Honda Y (January 2002). "Selective induction of neuropilin-1 by vascular endothelial growth factor (VEGF): a mechanism contributing to VEGF-induced angiogenesis". Proceedings of the National Academy of Sciences of the United States of America. 99 (1): 383–8. Bibcode: 2002PNAS...99..383O. doi: 10.1073/pnas.012074399. PMC 117569. PMID 11756651.
- Fakhari M, Pullirsch D, Abraham D, Paya K, Hofbauer R, Holzfeind P, et al. (January 2002). "Selective upregulation of vascular endothelial growth factor receptors neuropilin-1 and -2 in human neuroblastoma". Cancer. 94 (1): 258–63. doi: 10.1002/cncr.10177. PMID 11815985. S2CID 45773136.
- Cohen T, Herzog Y, Brodzky A, Greenson JK, Eldar S, Gluzman-Poltorak Z, et al. (September 2002). "Neuropilin-2 is a novel marker expressed in pancreatic islet cells and endocrine pancreatic tumours". The Journal of Pathology. 198 (1): 77–82. doi: 10.1002/path.1179. PMID 12210066. S2CID 24579823.
- Kawakami T, Tokunaga T, Hatanaka H, Kijima H, Yamazaki H, Abe Y, et al. (November 2002). "Neuropilin 1 and neuropilin 2 co-expression is significantly correlated with increased vascularity and poor prognosis in nonsmall cell lung carcinoma". Cancer. 95 (10): 2196–201. doi: 10.1002/cncr.10936. PMID 12412174. S2CID 28744286.
|
| This article on a gene on human chromosome 2 is a stub. You can help Wikipedia by expanding it. |