| NHP2 | |||||||||||||||||||||||||||||||||||||||||||||||||||
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| Identifiers | |||||||||||||||||||||||||||||||||||||||||||||||||||
| Aliases | NHP2, DKCB2, NHP2P, NOLA2, NHP2 ribonucleoprotein | ||||||||||||||||||||||||||||||||||||||||||||||||||
| External IDs | OMIM: 606470; MGI: 1098547; HomoloGene: 5524; GeneCards: NHP2; OMA: NHP2 - orthologs | ||||||||||||||||||||||||||||||||||||||||||||||||||
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| Wikidata | |||||||||||||||||||||||||||||||||||||||||||||||||||
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H/ACA ribonucleoprotein complex subunit 2 is a protein that in humans is encoded by the NHP2 gene. [5] [6]
This gene is a member of the H/ACA snoRNPs (small nucleolar ribonucleoproteins) gene family. snoRNPs are involved in various aspects of rRNA processing and modification and have been classified into two families: C/D and H/ACA.
The H/ACA snoRNPs also include the DKC1, NOLA1 and NOLA3 proteins. These four H/ACA snoRNP proteins localize to the dense fibrillar components of nucleoli and to coiled ( Cajal) bodies in the nucleus. Both 18S rRNA production and rRNA pseudouridylation are impaired if any one of the four proteins is depleted. The four H/ACA snoRNP proteins are also components of the telomerase complex. This gene encodes a protein related to Saccharomyces cerevisiae Nhp2p. Two transcript variants encoding different isoforms have been found for this gene. [6]
References
- ^ a b c GRCh38: Ensembl release 89: ENSG00000145912 – Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000001056 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ Pogacic V, Dragon F, Filipowicz W (Dec 2000). "Human H/ACA small nucleolar RNPs and telomerase share evolutionarily conserved proteins NHP2 and NOP10". Mol Cell Biol. 20 (23): 9028–40. doi: 10.1128/MCB.20.23.9028-9040.2000. PMC 86556. PMID 11074001.
- ^ a b "Entrez Gene: NOLA2 nucleolar protein family A, member 2 (H/ACA small nucleolar RNPs)".
Further reading
- Henras A, Henry Y, Bousquet-Antonelli C, et al. (1999). "Nhp2p and Nop10p are essential for the function of H/ACA snoRNPs". EMBO J. 17 (23): 7078–90. doi: 10.1093/emboj/17.23.7078. PMC 1171055. PMID 9843512.
- Sanger Centre T, Washington University Genome Sequencing Cente T (1999). "Toward a complete human genome sequence". Genome Res. 8 (11): 1097–108. doi: 10.1101/gr.8.11.1097. PMID 9847074.
- Zhang QH, Ye M, Wu XY, et al. (2001). "Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells". Genome Res. 10 (10): 1546–60. doi: 10.1101/gr.140200. PMC 310934. PMID 11042152.
- Andersen JS, Lyon CE, Fox AH, et al. (2002). "Directed proteomic analysis of the human nucleolus". Curr. Biol. 12 (1): 1–11. Bibcode: 2002CBio...12....1A. doi: 10.1016/S0960-9822(01)00650-9. PMID 11790298. S2CID 14132033.
- Kang HS, Jung HM, Jun DY, et al. (2002). "Expression of the human homologue of the small nucleolar RNA-binding protein NHP2 gene during monocytic differentiation of U937 cells". Biochim. Biophys. Acta. 1575 (1–3): 31–9. doi: 10.1016/s0167-4781(02)00240-3. PMID 12020816.
- Scherl A, Couté Y, Déon C, et al. (2003). "Functional proteomic analysis of human nucleolus". Mol. Biol. Cell. 13 (11): 4100–9. doi: 10.1091/mbc.E02-05-0271. PMC 133617. PMID 12429849.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode: 2002PNAS...9916899M. doi: 10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi: 10.1038/ng1285. PMID 14702039.
- Wang C, Meier UT (2005). "Architecture and assembly of mammalian H/ACA small nucleolar and telomerase ribonucleoproteins". EMBO J. 23 (8): 1857–67. doi: 10.1038/sj.emboj.7600181. PMC 394235. PMID 15044956.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi: 10.1101/gr.2596504. PMC 528928. PMID 15489334.
- Andersen JS, Lam YW, Leung AK, et al. (2005). "Nucleolar proteome dynamics". Nature. 433 (7021): 77–83. Bibcode: 2005Natur.433...77A. doi: 10.1038/nature03207. PMID 15635413. S2CID 4344740.
- Slizhikova DK, Vinogradova TV, Sverdlov ED (2005). "[The NOLA2 and RPS3A genes as highly informative markers for human squamous cell lung cancer]". Bioorg. Khim. 31 (2): 195–9. doi: 10.1007/s11171-005-0024-6. PMID 15889794. S2CID 21342977.
 | This article on a gene on human chromosome 5 is a stub. You can help Wikipedia by expanding it. |
| NHP2 | |||||||||||||||||||||||||||||||||||||||||||||||||||
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| Identifiers | |||||||||||||||||||||||||||||||||||||||||||||||||||
| Aliases | NHP2, DKCB2, NHP2P, NOLA2, NHP2 ribonucleoprotein | ||||||||||||||||||||||||||||||||||||||||||||||||||
| External IDs | OMIM: 606470; MGI: 1098547; HomoloGene: 5524; GeneCards: NHP2; OMA: NHP2 - orthologs | ||||||||||||||||||||||||||||||||||||||||||||||||||
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| Wikidata | |||||||||||||||||||||||||||||||||||||||||||||||||||
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H/ACA ribonucleoprotein complex subunit 2 is a protein that in humans is encoded by the NHP2 gene. [5] [6]
This gene is a member of the H/ACA snoRNPs (small nucleolar ribonucleoproteins) gene family. snoRNPs are involved in various aspects of rRNA processing and modification and have been classified into two families: C/D and H/ACA.
The H/ACA snoRNPs also include the DKC1, NOLA1 and NOLA3 proteins. These four H/ACA snoRNP proteins localize to the dense fibrillar components of nucleoli and to coiled ( Cajal) bodies in the nucleus. Both 18S rRNA production and rRNA pseudouridylation are impaired if any one of the four proteins is depleted. The four H/ACA snoRNP proteins are also components of the telomerase complex. This gene encodes a protein related to Saccharomyces cerevisiae Nhp2p. Two transcript variants encoding different isoforms have been found for this gene. [6]
References
- ^ a b c GRCh38: Ensembl release 89: ENSG00000145912 – Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000001056 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ Pogacic V, Dragon F, Filipowicz W (Dec 2000). "Human H/ACA small nucleolar RNPs and telomerase share evolutionarily conserved proteins NHP2 and NOP10". Mol Cell Biol. 20 (23): 9028–40. doi: 10.1128/MCB.20.23.9028-9040.2000. PMC 86556. PMID 11074001.
- ^ a b "Entrez Gene: NOLA2 nucleolar protein family A, member 2 (H/ACA small nucleolar RNPs)".
Further reading
- Henras A, Henry Y, Bousquet-Antonelli C, et al. (1999). "Nhp2p and Nop10p are essential for the function of H/ACA snoRNPs". EMBO J. 17 (23): 7078–90. doi: 10.1093/emboj/17.23.7078. PMC 1171055. PMID 9843512.
- Sanger Centre T, Washington University Genome Sequencing Cente T (1999). "Toward a complete human genome sequence". Genome Res. 8 (11): 1097–108. doi: 10.1101/gr.8.11.1097. PMID 9847074.
- Zhang QH, Ye M, Wu XY, et al. (2001). "Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells". Genome Res. 10 (10): 1546–60. doi: 10.1101/gr.140200. PMC 310934. PMID 11042152.
- Andersen JS, Lyon CE, Fox AH, et al. (2002). "Directed proteomic analysis of the human nucleolus". Curr. Biol. 12 (1): 1–11. Bibcode: 2002CBio...12....1A. doi: 10.1016/S0960-9822(01)00650-9. PMID 11790298. S2CID 14132033.
- Kang HS, Jung HM, Jun DY, et al. (2002). "Expression of the human homologue of the small nucleolar RNA-binding protein NHP2 gene during monocytic differentiation of U937 cells". Biochim. Biophys. Acta. 1575 (1–3): 31–9. doi: 10.1016/s0167-4781(02)00240-3. PMID 12020816.
- Scherl A, Couté Y, Déon C, et al. (2003). "Functional proteomic analysis of human nucleolus". Mol. Biol. Cell. 13 (11): 4100–9. doi: 10.1091/mbc.E02-05-0271. PMC 133617. PMID 12429849.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode: 2002PNAS...9916899M. doi: 10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi: 10.1038/ng1285. PMID 14702039.
- Wang C, Meier UT (2005). "Architecture and assembly of mammalian H/ACA small nucleolar and telomerase ribonucleoproteins". EMBO J. 23 (8): 1857–67. doi: 10.1038/sj.emboj.7600181. PMC 394235. PMID 15044956.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi: 10.1101/gr.2596504. PMC 528928. PMID 15489334.
- Andersen JS, Lam YW, Leung AK, et al. (2005). "Nucleolar proteome dynamics". Nature. 433 (7021): 77–83. Bibcode: 2005Natur.433...77A. doi: 10.1038/nature03207. PMID 15635413. S2CID 4344740.
- Slizhikova DK, Vinogradova TV, Sverdlov ED (2005). "[The NOLA2 and RPS3A genes as highly informative markers for human squamous cell lung cancer]". Bioorg. Khim. 31 (2): 195–9. doi: 10.1007/s11171-005-0024-6. PMID 15889794. S2CID 21342977.
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| This article on a gene on human chromosome 5 is a stub. You can help Wikipedia by expanding it. |