NFAT activating protein with ITAM motif 1 is a protein that in humans is encoded by the NFAM1 gene. [5]
Function
The protein encoded by this gene is a type I membrane receptor that activates cytokine gene promoters such as the IL-13 and TNF-alpha promoters. The encoded protein contains an Immunoreceptor tyrosine-based activation motif (ITAM) and is thought to regulate the signaling and development of B-cells. [provided by RefSeq, Jul 2008].
References
- ^ a b c GRCh38: Ensembl release 89: ENSG00000235568 – Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000058099 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Entrez Gene: NFAT activating protein with ITAM motif 1". Retrieved 2018-03-13.
Further reading
- Yang J, Hu G, Wang SW, Li Y, Martin R, Li K, Yao Z (May 2003). "Calcineurin/nuclear factors of activated T cells (NFAT)-activating and immunoreceptor tyrosine-based activation motif (ITAM)-containing protein (CNAIP), a novel ITAM-containing protein that activates the calcineurin/NFAT-signaling pathway". J. Biol. Chem. 278 (19): 16797–801. doi: 10.1074/jbc.M211060200. PMID 12615919.
- Nilsson LM, Sun ZW, Nilsson J, Nordström I, Chen YW, Molkentin JD, Wide-Swensson D, Hellstrand P, Lydrup ML, Gomez MF (March 2007). "Novel blocker of NFAT activation inhibits IL-6 production in human myometrial arteries and reduces vascular smooth muscle cell proliferation" (PDF). Am. J. Physiol., Cell Physiol. 292 (3): C1167–78. doi: 10.1152/ajpcell.00590.2005. PMID 17079331.
- Manley K, O'Hara BA, Atwood WJ (March 2008). "Nuclear factor of activated T-cells (NFAT) plays a role in SV40 infection". Virology. 372 (1): 48–55. doi: 10.1016/j.virol.2007.10.029. PMC 2289909. PMID 18031784.
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
 | This article on a gene on human chromosome 22 is a stub. You can help Wikipedia by expanding it. |
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| Aliases | NFAM1, CNAIP, bK126B4.4, NFAT activating protein with ITAM motif 1 | ||||||||||||||||||||||||||||||||||||||||||||||||||
| External IDs | OMIM: 608740; MGI: 1921289; HomoloGene: 12528; GeneCards: NFAM1; OMA: NFAM1 - orthologs | ||||||||||||||||||||||||||||||||||||||||||||||||||
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NFAT activating protein with ITAM motif 1 is a protein that in humans is encoded by the NFAM1 gene. [5]
Function
The protein encoded by this gene is a type I membrane receptor that activates cytokine gene promoters such as the IL-13 and TNF-alpha promoters. The encoded protein contains an Immunoreceptor tyrosine-based activation motif (ITAM) and is thought to regulate the signaling and development of B-cells. [provided by RefSeq, Jul 2008].
References
- ^ a b c GRCh38: Ensembl release 89: ENSG00000235568 – Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000058099 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Entrez Gene: NFAT activating protein with ITAM motif 1". Retrieved 2018-03-13.
Further reading
- Yang J, Hu G, Wang SW, Li Y, Martin R, Li K, Yao Z (May 2003). "Calcineurin/nuclear factors of activated T cells (NFAT)-activating and immunoreceptor tyrosine-based activation motif (ITAM)-containing protein (CNAIP), a novel ITAM-containing protein that activates the calcineurin/NFAT-signaling pathway". J. Biol. Chem. 278 (19): 16797–801. doi: 10.1074/jbc.M211060200. PMID 12615919.
- Nilsson LM, Sun ZW, Nilsson J, Nordström I, Chen YW, Molkentin JD, Wide-Swensson D, Hellstrand P, Lydrup ML, Gomez MF (March 2007). "Novel blocker of NFAT activation inhibits IL-6 production in human myometrial arteries and reduces vascular smooth muscle cell proliferation" (PDF). Am. J. Physiol., Cell Physiol. 292 (3): C1167–78. doi: 10.1152/ajpcell.00590.2005. PMID 17079331.
- Manley K, O'Hara BA, Atwood WJ (March 2008). "Nuclear factor of activated T-cells (NFAT) plays a role in SV40 infection". Virology. 372 (1): 48–55. doi: 10.1016/j.virol.2007.10.029. PMC 2289909. PMID 18031784.
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
|
| This article on a gene on human chromosome 22 is a stub. You can help Wikipedia by expanding it. |