Protein NDRG2 is a
protein that in humans is encoded by the NDRG2gene (NMYC downstream-regulated gene 2).[5][6]
Function
This gene is a member of the
N-myc downregulated gene family which belongs to the
alpha/beta hydrolase superfamily. The protein encoded by this gene is a
cytoplasmic protein that may play a role in
neurite outgrowth. This gene may be involved in
glioblastoma and aggressive
meningiomacarcinogenesis (via cell proliferation[7]).[8] Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined.[6]
Zhou RH, Kokame K, Tsukamoto Y, et al. (2001). "Characterization of the human NDRG gene family: a newly identified member, NDRG4, is specifically expressed in brain and heart". Genomics. 73 (1): 86–97.
doi:
10.1006/geno.2000.6496.
PMID11352569.
Qu X, Zhai Y, Wei H, et al. (2002). "Characterization and expression of three novel differentiation-related genes belong to the human NDRG gene family". Mol. Cell. Biochem. 229 (1–2): 35–44.
doi:
10.1023/A:1017934810825.
PMID11936845.
S2CID24226208.
Ohki T, Hongo S, Nakada N, et al. (2002). "Inhibition of neurite outgrowth by reduced level of NDRG4 protein in antisense transfected PC12 cells". Brain Res. Dev. Brain Res. 135 (1–2): 55–63.
doi:
10.1016/S0165-3806(02)00300-0.
PMID11978393.
Protein NDRG2 is a
protein that in humans is encoded by the NDRG2gene (NMYC downstream-regulated gene 2).[5][6]
Function
This gene is a member of the
N-myc downregulated gene family which belongs to the
alpha/beta hydrolase superfamily. The protein encoded by this gene is a
cytoplasmic protein that may play a role in
neurite outgrowth. This gene may be involved in
glioblastoma and aggressive
meningiomacarcinogenesis (via cell proliferation[7]).[8] Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined.[6]
Zhou RH, Kokame K, Tsukamoto Y, et al. (2001). "Characterization of the human NDRG gene family: a newly identified member, NDRG4, is specifically expressed in brain and heart". Genomics. 73 (1): 86–97.
doi:
10.1006/geno.2000.6496.
PMID11352569.
Qu X, Zhai Y, Wei H, et al. (2002). "Characterization and expression of three novel differentiation-related genes belong to the human NDRG gene family". Mol. Cell. Biochem. 229 (1–2): 35–44.
doi:
10.1023/A:1017934810825.
PMID11936845.
S2CID24226208.
Ohki T, Hongo S, Nakada N, et al. (2002). "Inhibition of neurite outgrowth by reduced level of NDRG4 protein in antisense transfected PC12 cells". Brain Res. Dev. Brain Res. 135 (1–2): 55–63.
doi:
10.1016/S0165-3806(02)00300-0.
PMID11978393.