neighbor of BRCA1 gene 2 | |
---|---|
Identifiers | |
Symbol | NBR2 |
NCBI gene | 10230 |
HGNC | 20691 |
RefSeq | NM_005821 |
Other data | |
Locus | Chr. 17 q21 |
NBR2 is a gene best known for its location near the breast cancer associated gene BRCA1. [1] Like BRCA1, NBR2 has been a subject of research, [2] but links to breast cancer are currently inconclusive.
NBR2 recently was identified as a glucose starvation-induced long non-coding RNA. NBR2 interacts with AMP-activated protein kinase ( AMPK), a critical energy sensor in most eukaryotic cells, and promotes AMPK function to mediate energy stress response. Knockdown of NBR2 attenuates energy stress-induced AMPK activation, resulting in unchecked cell cycling, altered apoptosis/ autophagy response, and increased tumour development in vivo. [3] [4] It is now appreciated that NBR2, a former junk gene, plays critical roles in tumor suppression. [5]
neighbor of BRCA1 gene 2 | |
---|---|
Identifiers | |
Symbol | NBR2 |
NCBI gene | 10230 |
HGNC | 20691 |
RefSeq | NM_005821 |
Other data | |
Locus | Chr. 17 q21 |
NBR2 is a gene best known for its location near the breast cancer associated gene BRCA1. [1] Like BRCA1, NBR2 has been a subject of research, [2] but links to breast cancer are currently inconclusive.
NBR2 recently was identified as a glucose starvation-induced long non-coding RNA. NBR2 interacts with AMP-activated protein kinase ( AMPK), a critical energy sensor in most eukaryotic cells, and promotes AMPK function to mediate energy stress response. Knockdown of NBR2 attenuates energy stress-induced AMPK activation, resulting in unchecked cell cycling, altered apoptosis/ autophagy response, and increased tumour development in vivo. [3] [4] It is now appreciated that NBR2, a former junk gene, plays critical roles in tumor suppression. [5]