NAPG

NAPG
Identifiers
Aliases	NAPG, GAMMASNAP, NSF attachment protein gamma
External IDs	OMIM: 603216; MGI: 104561; HomoloGene: 2838; GeneCards: NAPG; OMA: NAPG - orthologs
Gene location ( Human)
Chr.	Chromosome 18 (human)
End	10,552,764 bp
Gene location ( Mouse)
Chr.	Chromosome 18 (mouse)
End	63,132,521 bp
RNA expression pattern
	Top expressed in
	endothelial cell; ; pons; ; Pars compacta; ; Brodmann area 23; ; islet of Langerhans; ; C1 segment; ; lateral nuclear group of thalamus; ; middle temporal gyrus; ; dorsolateral prefrontal cortex; ; Brodmann area 9;
	Top expressed in
	subiculum; ; pontine nuclei; ; piriform cortex; ; central gray substance of midbrain; ; medial dorsal nucleus; ; primary motor cortex; ; inferior colliculus; ; subdivision of hippocampus; ; Region I of hippocampus proper; ; habenula;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	syntaxin binding; protein binding; soluble NSF attachment protein activity;
Cellular component	myelin sheath; lysosomal membrane; SNARE complex; extracellular exosome; membrane; mitochondrion; vacuolar membrane; synapse;
Biological process	protein transport; protein stabilization; membrane fusion; intracellular protein transport; intra-Golgi vesicle-mediated transport; vesicle-mediated transport; transport; protein-containing complex assembly;
	Sources: Amigo / QuickGO
Orthologs
	8774
	108123
	ENSG00000134265
	ENSMUSG00000024581
	Q99747
	Q9CWZ7
	NM_003826
	NM_028017
	NP_003817
	NP_082293
	Wikidata
View/Edit Human	View/Edit Mouse

Gamma-soluble NSF attachment protein is a SNAP protein that in humans is encoded by the NAPG gene.^[5]^[6]

Function

NSF and SNAPs (NSF attachment proteins) are general elements of the cellular membrane transport apparatus. The sequence of the predicted 312-amino acid human protein encoded by NAPG is 95% identical to that of bovine gamma- SNAP. NAPG mediates platelet exocytosis and controls the membrane fusion events of this process.^[6]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000134265 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000024581 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Lemons PP, Chen D, Bernstein AM, Bennett MK, Whiteheart SW (Sep 1997). "Regulated secretion in platelets: identification of elements of the platelet exocytosis machinery". Blood. 90 (4): 1490–500. doi: 10.1182/blood.V90.4.1490. PMID 9269766.
^ ^a ^b "Entrez Gene: NAPG N-ethylmaleimide-sensitive factor attachment protein, gamma".

Wilson DW, Whiteheart SW, Wiedmann M, et al. (1992). "A multisubunit particle implicated in membrane fusion". J. Cell Biol. 117 (3): 531–8. doi: 10.1083/jcb.117.3.531. PMC 2289450. PMID 1315316.
Whiteheart SW, Brunner M, Wilson DW, et al. (1992). "Soluble N-ethylmaleimide-sensitive fusion attachment proteins (SNAPs) bind to a multi-SNAP receptor complex in Golgi membranes". J. Biol. Chem. 267 (17): 12239–43. doi: 10.1016/S0021-9258(19)49830-X. PMID 1601890.
Whiteheart SW, Griff IC, Brunner M, et al. (1993). "SNAP family of NSF attachment proteins includes a brain-specific isoform". Nature. 362 (6418): 353–5. Bibcode: 1993Natur.362..353W. doi: 10.1038/362353a0. PMID 8455721. S2CID 4341471.
Andersson B, Wentland MA, Ricafrente JY, et al. (1996). "A "double adaptor" method for improved shotgun library construction". Anal. Biochem. 236 (1): 107–13. doi: 10.1006/abio.1996.0138. PMID 8619474.
Yu W, Andersson B, Worley KC, et al. (1997). "Large-scale concatenation cDNA sequencing". Genome Res. 7 (4): 353–8. doi: 10.1101/gr.7.4.353. PMC 139146. PMID 9110174.
Mastick CC, Falick AL (1997). "Association of N-ethylmaleimide sensitive fusion (NSF) protein and soluble NSF attachment proteins-alpha and -gamma with glucose transporter-4-containing vesicles in primary rat adipocytes". Endocrinology. 138 (6): 2391–7. doi: 10.1210/endo.138.6.5166. PMID 9165027.
Subramaniam VN, Loh E, Horstmann H, et al. (2000). "Preferential association of syntaxin 8 with the early endosome" (PDF). J. Cell Sci. 113 (6): 997–1008. doi: 10.1242/jcs.113.6.997. PMID 10683148.
Chen D, Xu W, He P, et al. (2001). "Gaf-1, a gamma -SNAP-binding protein associated with the mitochondria". J. Biol. Chem. 276 (16): 13127–35. doi: 10.1074/jbc.M009424200. PMID 11278501.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode: 2002PNAS...9916899M. doi: 10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Tani K, Shibata M, Kawase K, et al. (2003). "Mapping of functional domains of gamma-SNAP". J. Biol. Chem. 278 (15): 13531–8. doi: 10.1074/jbc.M213205200. PMID 12554740.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi: 10.1038/ng1285. PMID 14702039.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi: 10.1101/gr.2596504. PMC 528928. PMID 15489334.
Rush J, Moritz A, Lee KA, et al. (2005). "Immunoaffinity profiling of tyrosine phosphorylation in cancer cells". Nat. Biotechnol. 23 (1): 94–101. doi: 10.1038/nbt1046. PMID 15592455. S2CID 7200157.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode: 2005Natur.437.1173R. doi: 10.1038/nature04209. PMID 16189514. S2CID 4427026.

This article on a gene on human chromosome 18 is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000134265 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000024581 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9269766-5] Lemons PP, Chen D, Bernstein AM, Bennett MK, Whiteheart SW (Sep 1997). "Regulated secretion in platelets: identification of elements of the platelet exocytosis machinery". Blood. 90 (4): 1490–500. doi: 10.1182/blood.V90.4.1490. PMID 9269766.

[entrez-6] "Entrez Gene: NAPG N-ethylmaleimide-sensitive factor attachment protein, gamma".

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