Nascent-polypeptide-associated complex alpha polypeptide, also known as NACA, is a
protein which in humans is encoded by the NACAgene.[5][6][7]
Function
NACA prevents short recently synthesized (i.e., nascent)
ribosome-associated polypeptides from inappropriate interactions with
cytosolic proteins. NACA binds nascent-polypeptide domains emerging from ribosomes unless it contains a
signal peptide which is fully exposed. Depletion of NACA from ribosomes carrying nascent polypeptides allows the
signal recognition particle (SRP) to crosslink to polypeptides regardless of whether or not they contain signal peptides or not. In the absence of NACA, proteins lacking signal peptides can be mis-
translocated into the
endoplasmic reticulum.[6][8]
The NACA protein is expressed in bone during
development and acts as a transcriptional
coactivator in conjunction with acidic activators.[7]
^Stilo R, Liguoro D, di Jeso B, Leonardi A, Vito P (April 2003). "The alpha-chain of the nascent polypeptide-associated complex binds to and regulates FADD function". Biochem. Biophys. Res. Commun. 303 (4): 1034–41.
doi:
10.1016/S0006-291X(03)00487-X.
PMID12684039.
Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4.
doi:
10.1016/0378-1119(94)90802-8.
PMID8125298.
Yotov WV, St-Arnaud R (1996). "Mapping of the human gene for the alpha-NAC/1.9.2 (NACA/1.9.2) transcriptional coactivator to Chromosome 12q23-24.1". Mamm. Genome. 7 (2): 163–4.
doi:
10.1007/BF03035343.
PMID8835540.
S2CID33088429.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56.
doi:
10.1016/S0378-1119(97)00411-3.
PMID9373149.
Stilo R, Liguoro D, di Jeso B, et al. (2003). "The alpha-chain of the nascent polypeptide-associated complex binds to and regulates FADD function". Biochem. Biophys. Res. Commun. 303 (4): 1034–41.
doi:
10.1016/S0006-291X(03)00487-X.
PMID12684039.
Papachristou DJ, Batistatou A, Sykiotis GP, et al. (2003). "Activation of the JNK-AP-1 signal transduction pathway is associated with pathogenesis and progression of human osteosarcomas". Bone. 32 (4): 364–71.
doi:
10.1016/S8756-3282(03)00026-7.
PMID12689679.
Hämmerle K, Shayan P, Niemeyer CM, Flotho C (2003). "Expression analysis of alpha-NAC and ANX2 in juvenile myelomonocytic leukemia using SMART polymerase chain reaction and "virtual Northern" hybridization". Cancer Genet. Cytogenet. 142 (2): 149–52.
doi:
10.1016/S0165-4608(02)00841-5.
PMID12699894.
Nascent-polypeptide-associated complex alpha polypeptide, also known as NACA, is a
protein which in humans is encoded by the NACAgene.[5][6][7]
Function
NACA prevents short recently synthesized (i.e., nascent)
ribosome-associated polypeptides from inappropriate interactions with
cytosolic proteins. NACA binds nascent-polypeptide domains emerging from ribosomes unless it contains a
signal peptide which is fully exposed. Depletion of NACA from ribosomes carrying nascent polypeptides allows the
signal recognition particle (SRP) to crosslink to polypeptides regardless of whether or not they contain signal peptides or not. In the absence of NACA, proteins lacking signal peptides can be mis-
translocated into the
endoplasmic reticulum.[6][8]
The NACA protein is expressed in bone during
development and acts as a transcriptional
coactivator in conjunction with acidic activators.[7]
^Stilo R, Liguoro D, di Jeso B, Leonardi A, Vito P (April 2003). "The alpha-chain of the nascent polypeptide-associated complex binds to and regulates FADD function". Biochem. Biophys. Res. Commun. 303 (4): 1034–41.
doi:
10.1016/S0006-291X(03)00487-X.
PMID12684039.
Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4.
doi:
10.1016/0378-1119(94)90802-8.
PMID8125298.
Yotov WV, St-Arnaud R (1996). "Mapping of the human gene for the alpha-NAC/1.9.2 (NACA/1.9.2) transcriptional coactivator to Chromosome 12q23-24.1". Mamm. Genome. 7 (2): 163–4.
doi:
10.1007/BF03035343.
PMID8835540.
S2CID33088429.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56.
doi:
10.1016/S0378-1119(97)00411-3.
PMID9373149.
Stilo R, Liguoro D, di Jeso B, et al. (2003). "The alpha-chain of the nascent polypeptide-associated complex binds to and regulates FADD function". Biochem. Biophys. Res. Commun. 303 (4): 1034–41.
doi:
10.1016/S0006-291X(03)00487-X.
PMID12684039.
Papachristou DJ, Batistatou A, Sykiotis GP, et al. (2003). "Activation of the JNK-AP-1 signal transduction pathway is associated with pathogenesis and progression of human osteosarcomas". Bone. 32 (4): 364–71.
doi:
10.1016/S8756-3282(03)00026-7.
PMID12689679.
Hämmerle K, Shayan P, Niemeyer CM, Flotho C (2003). "Expression analysis of alpha-NAC and ANX2 in juvenile myelomonocytic leukemia using SMART polymerase chain reaction and "virtual Northern" hybridization". Cancer Genet. Cytogenet. 142 (2): 149–52.
doi:
10.1016/S0165-4608(02)00841-5.
PMID12699894.