N-PHENACYL THIAZOLIUM BROMIDE

N-Phenacylthiazolium bromide
Names
	Preferred IUPAC name 3-(2-Oxo-2-phenylethyl)-1,3-thiazol-3-ium bromide
Identifiers
CAS Number	5304-34-7;
3D model ( JSmol)	Interactive image;
ChemSpider	7990117;
MeSH	C101705
PubChem CID	9814367;
UNII	JE6JEU5BW6 ;
CompTox Dashboard ( EPA)	DTXSID30431106 ;
	InChI InChI=1S/C11H10NOS.BrH/c13-11(8-12-6-7-14-9-12)10-4-2-1-3-5-10;/h1-7,9H,8H2;1H/q+1;/p-1 Key: CEAFABGKSOIJLH-UHFFFAOYSA-M;
	SMILES C1=CC=C(C=C1)C(=O)C[N+]2=CSC=C2.[Br-];
Properties
Chemical formula	C11H10BrNOS
Molar mass	284.17 g·mol−1
	Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). Infobox references

N-Phenacylthiazolium bromide (PTB)^[1] is a cross-link breaker that in one study has been shown to prevent vascular advanced glycation end-product accumulation in diabetic rats.^[2]

References

^ Chang, Po-Chun; Tsai, Sheng-Chueh; Chong, Li Yen; Kao, Man-Jung (July 22, 2014). "N-Phenacylthiazolium bromide inhibits the advanced glycation end product (AGE)-AGE receptor axis to modulate experimental periodontitis in rats". Journal of Periodontology. 85 (7): e268–276. doi: 10.1902/jop.2014.130554. PMID 24988129.
^ Cooper, M. E.; Thallas, V; Forbes, J; Scalbert, E; Sastra, S; Darby, I; Soulis, T (2000). "The cross-link breaker, N-phenacylthiazolium bromide prevents vascular advanced glycation end-product accumulation". Diabetologia. 43 (5): 660–664. doi: 10.1007/s001250051355. PMID 10855541.

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[1] Chang, Po-Chun; Tsai, Sheng-Chueh; Chong, Li Yen; Kao, Man-Jung (July 22, 2014). "N-Phenacylthiazolium bromide inhibits the advanced glycation end product (AGE)-AGE receptor axis to modulate experimental periodontitis in rats". Journal of Periodontology. 85 (7): e268–276. doi: 10.1902/jop.2014.130554. PMID 24988129.

[MyUser_Ncbi.nlm.nih.gov_January_17_2016c-2] Cooper, M. E.; Thallas, V; Forbes, J; Scalbert, E; Sastra, S; Darby, I; Soulis, T (2000). "The cross-link breaker, N-phenacylthiazolium bromide prevents vascular advanced glycation end-product accumulation". Diabetologia. 43 (5): 660–664. doi: 10.1007/s001250051355. PMID 10855541.

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