From Wikipedia, the free encyclopedia
Protein-coding gene in the species Homo sapiens
N-acetyltransferase 1 (arylamine N-acetyltransferase) is a
protein that in humans is encoded by the NAT1
gene.
[5]
This gene is one of two
arylamine
N-acetyltransferase (NAT) genes in the
human genome, and is
orthologous to the mouse and rat
NAT2 genes. The enzyme encoded by this gene catalyzes the transfer of an
acetyl group from
acetyl-CoA to various arylamine and
hydrazine
substrates. This enzyme helps metabolize drugs and other
xenobiotics, and functions in
folate
catabolism. Multiple
transcript variants encoding different
isoforms have been found for this gene. [provided by RefSeq, Aug 2011].
[5]
References
Further reading
- Gubin AN, Njoroge JM, Bouffard GG, Miller JL (July 1999).
"Gene expression in proliferating human erythroid cells". Genomics. 59 (2): 168–77.
doi:
10.1006/geno.1999.5855.
PMID
10409428.
- Smelt VA, Upton A, Adjaye J, Payton MA, Boukouvala S, Johnson N, Mardon HJ, Sim E (April 2000).
"Expression of arylamine N-acetyltransferases in pre-term placentas and in human pre-implantation embryos". Human Molecular Genetics. 9 (7): 1101–7.
doi:
10.1093/hmg/9.7.1101.
PMID
10767335.
- Brockton N, Little J, Sharp L, Cotton SC (May 2000).
"N-acetyltransferase polymorphisms and colorectal cancer: a HuGE review". American Journal of Epidemiology. 151 (9): 846–61.
doi:
10.1093/oxfordjournals.aje.a010289.
PMID
10791558.
- Lo-Guidice JM, Allorge D, Chevalier D, Debuysère H, Fazio F, Lafitte LJ, Broly F (June 2000). "Molecular analysis of the N-acetyltransferase 1 gene (NAT1*) using polymerase chain reaction-restriction fragment-single strand conformation polymorphism assay". Pharmacogenetics. 10 (4): 293–300.
doi:
10.1097/00008571-200006000-00003.
PMID
10862520.
- de León JH, Vatsis KP, Weber WW (August 2000). "Characterization of naturally occurring and recombinant human N-acetyltransferase variants encoded by NAT1". Molecular Pharmacology. 58 (2): 288–99.
doi:
10.1124/mol.58.2.288.
PMID
10908296.
- Yu MW, Pai CI, Yang SY, Hsiao TJ, Chang HC, Lin SM,
Liaw YF,
Chen PJ,
Chen CJ (November 2000).
"Role of N-acetyltransferase polymorphisms in hepatitis B related hepatocellular carcinoma: impact of smoking on risk". Gut. 47 (5): 703–9.
doi:
10.1136/gut.47.5.703.
PMC
1728099.
PMID
11034589.
- Wikman H, Thiel S, Jäger B, Schmezer P, Spiegelhalder B, Edler L, Dienemann H, Kayser K, Schulz V, Drings P, Bartsch H, Risch A (March 2001). "Relevance of N-acetyltransferase 1 and 2 (NAT1, NAT2) genetic polymorphisms in non-small cell lung cancer susceptibility". Pharmacogenetics. 11 (2): 157–68.
doi:
10.1097/00008571-200103000-00006.
PMID
11266080.
- Krajinovic M, Ghadirian P, Richer C, Sinnett H, Gandini S, Perret C, Lacroix A, Labuda D, Sinnett D (April 2001).
"Genetic susceptibility to breast cancer in French-Canadians: role of carcinogen-metabolizing enzymes and gene-environment interactions". International Journal of Cancer. 92 (2): 220–5.
doi:
10.1002/1097-0215(200102)9999:9999<::AID-IJC1184>3.0.CO;2-H.
PMID
11291049.
S2CID
19448901.
- Sekine A, Saito S, Iida A, Mitsunobu Y, Higuchi S, Harigae S, Nakamura Y (2001).
"Identification of single-nucleotide polymorphisms (SNPs) of human N-acetyltransferase genes NAT1, NAT2, AANAT, ARD1 and L1CAM in the Japanese population". Journal of Human Genetics. 46 (6): 314–9.
doi:
10.1007/s100380170065.
PMID
11393533.
- Butler WJ, Ryan P, Roberts-Thomson IC (June 2001). "Metabolic genotypes and risk for colorectal cancer". Journal of Gastroenterology and Hepatology. 16 (6): 631–5.
doi:
10.1046/j.1440-1746.2001.02501.x.
PMID
11422615.
S2CID
37057726.