He then became a researcher and professor (associate) at
Bahauddin Zakariya University,
Multan,
Pakistan.[8] There, he is heading "Phage Therapy & Drug Design Laboratory" of Institute of Molecular Biology and Biotechnology.[9]
Qadirvirtide and Qadir-C30: His work also includes invention of anti-HIV drugs, Qadirvirtide[12][13][14][15] and Qadir-C30.[16][17][18] These are fusion inhibitors that may be used as prophylaxis or for the treatment of
AIDS. These are synthetic
peptides composed of 36 and 30 amino acids respectively. These block the entry of
HIVgenome into human CD4 cells by binding to HR1 region of
spike protein of
HIV, so that the virus can not come close to the human cell membrane and ultimately fusion of the viral envelope with human cell membrane is prevented.[19]
Qadir theory of cancer etiology: He has posed that
viruses are the cause of
cancer, the idea was presented as a theory of cancer etiology.[20][21][22] He postulated that "Viruses are the causative agents of cancer: 100% of cancer patients contain virus/es in their body which are responsible for the cancer." He also argued that some studies have opposed the idea, but he rejected them because laboratory methods were not used to detect
viruses in those studies. The theory was concluded with the point that, in near future,
viruses will be isolated from all
cancer patients as causative agent of a specific
cancer.[23]
Qadirphages: He discovered local
bacteriophages to be used as anti-bacterial products which were named as Qadirphages.[24][25] The evolution of antibiotic resistance in
bacteria has increased research in the field of therapies to search alternative methods to control the
infections. Qadir isolated local
phages, characterized them and found their antibacterial activities. The phages showed maximum propagation at 37 °C indicating that these work best at human body temperature.
SDS-PAGE analysis confirmed the presence of
protein cover and showed the various bands ranging from 10 to 200 kDa.
Nucleic acid analysis confirmed the presence of
RNA with a size of approximately 20 kb.
Transmission electron microscopy indicated that the isolated phages belonged to Siphoviridae, Leviviridae, and Podoviridae families.[26]
Fungal Research: He also discovered new
genes in local
fungi which are involved in curing skin diseases caused by these local
fungi.[27]
QadirVID-19: He designed a fusion inhibitor for specific treatment of
COVID-19, which was named as QadirVID-19.[28] This drug is a synthetic peptide composed of 30 amino acids.[29] It is part of Heptad Repeat 2 (HR2) region of spike protein of 2019-nCoV which was found highly conserved region as it had 100% similarity, with
BLAST scoring of 99.5 and E-value of 5e−24.[30]
Publications: He has published more than 600 research articles.[31][32][33] He has also written and edited more 15 books in the field of medical sciences. Among them, "Rare and Uncommon Diseases"[34][35] and "Bacterial Diseases"[36] are famous.
Mentorship: He is an HEC approved supervisor for PhD research in Pakistan.[8][37] He has contributed in health-related community awareness programs.[38][39]
He then became a researcher and professor (associate) at
Bahauddin Zakariya University,
Multan,
Pakistan.[8] There, he is heading "Phage Therapy & Drug Design Laboratory" of Institute of Molecular Biology and Biotechnology.[9]
Qadirvirtide and Qadir-C30: His work also includes invention of anti-HIV drugs, Qadirvirtide[12][13][14][15] and Qadir-C30.[16][17][18] These are fusion inhibitors that may be used as prophylaxis or for the treatment of
AIDS. These are synthetic
peptides composed of 36 and 30 amino acids respectively. These block the entry of
HIVgenome into human CD4 cells by binding to HR1 region of
spike protein of
HIV, so that the virus can not come close to the human cell membrane and ultimately fusion of the viral envelope with human cell membrane is prevented.[19]
Qadir theory of cancer etiology: He has posed that
viruses are the cause of
cancer, the idea was presented as a theory of cancer etiology.[20][21][22] He postulated that "Viruses are the causative agents of cancer: 100% of cancer patients contain virus/es in their body which are responsible for the cancer." He also argued that some studies have opposed the idea, but he rejected them because laboratory methods were not used to detect
viruses in those studies. The theory was concluded with the point that, in near future,
viruses will be isolated from all
cancer patients as causative agent of a specific
cancer.[23]
Qadirphages: He discovered local
bacteriophages to be used as anti-bacterial products which were named as Qadirphages.[24][25] The evolution of antibiotic resistance in
bacteria has increased research in the field of therapies to search alternative methods to control the
infections. Qadir isolated local
phages, characterized them and found their antibacterial activities. The phages showed maximum propagation at 37 °C indicating that these work best at human body temperature.
SDS-PAGE analysis confirmed the presence of
protein cover and showed the various bands ranging from 10 to 200 kDa.
Nucleic acid analysis confirmed the presence of
RNA with a size of approximately 20 kb.
Transmission electron microscopy indicated that the isolated phages belonged to Siphoviridae, Leviviridae, and Podoviridae families.[26]
Fungal Research: He also discovered new
genes in local
fungi which are involved in curing skin diseases caused by these local
fungi.[27]
QadirVID-19: He designed a fusion inhibitor for specific treatment of
COVID-19, which was named as QadirVID-19.[28] This drug is a synthetic peptide composed of 30 amino acids.[29] It is part of Heptad Repeat 2 (HR2) region of spike protein of 2019-nCoV which was found highly conserved region as it had 100% similarity, with
BLAST scoring of 99.5 and E-value of 5e−24.[30]
Publications: He has published more than 600 research articles.[31][32][33] He has also written and edited more 15 books in the field of medical sciences. Among them, "Rare and Uncommon Diseases"[34][35] and "Bacterial Diseases"[36] are famous.
Mentorship: He is an HEC approved supervisor for PhD research in Pakistan.[8][37] He has contributed in health-related community awareness programs.[38][39]