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Clinical data | |
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Other names | Acetylhexa-L-lysyl-α-MSH |
ATC code |
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CAS Number | |
PubChem CID | |
ChemSpider | |
UNII | |
CompTox Dashboard ( EPA) | |
Chemical and physical data | |
Formula | C113H181N33O25S |
Molar mass | 2433.96 g·mol−1 |
3D model ( JSmol) | |
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Modimelanotide ( INN) (code names AP-214, ABT-719, ZP-1480) is a melanocortinergic peptide drug derived from α-melanocyte-stimulating hormone (α-MSH) which was under development by, at different times, Action Pharma, Abbott Laboratories, AbbVie, and Zealand for the treatment of acute kidney injury. [1] [2] It acts as a non-selective melanocortin receptor agonist, with IC50 values of 2.9 nM, 1.9 nM, 3.7 nM, and 110 nM at the MC1, MC3, MC4, and MC5 receptors. [3] Modimelanotide failed clinical trials for acute kidney injury despite showing efficacy in animal models, [4] [5] and development was not further pursued. [1] [2]
![]() | |
Clinical data | |
---|---|
Other names | Acetylhexa-L-lysyl-α-MSH |
ATC code |
|
Identifiers | |
| |
CAS Number | |
PubChem CID | |
ChemSpider | |
UNII | |
CompTox Dashboard ( EPA) | |
Chemical and physical data | |
Formula | C113H181N33O25S |
Molar mass | 2433.96 g·mol−1 |
3D model ( JSmol) | |
| |
|
Modimelanotide ( INN) (code names AP-214, ABT-719, ZP-1480) is a melanocortinergic peptide drug derived from α-melanocyte-stimulating hormone (α-MSH) which was under development by, at different times, Action Pharma, Abbott Laboratories, AbbVie, and Zealand for the treatment of acute kidney injury. [1] [2] It acts as a non-selective melanocortin receptor agonist, with IC50 values of 2.9 nM, 1.9 nM, 3.7 nM, and 110 nM at the MC1, MC3, MC4, and MC5 receptors. [3] Modimelanotide failed clinical trials for acute kidney injury despite showing efficacy in animal models, [4] [5] and development was not further pursued. [1] [2]