![]() Mirabamide A–D
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Identifiers | |
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3D model (
JSmol)
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ChEBI |
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ChEMBL | |
ChemSpider | |
PubChem
CID
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Except where otherwise noted, data are given for materials in their
standard state (at 25 °C [77 °F], 100 kPa).
|
Mirabamides are sea sponge isolates that inhibit HIV-1 fusion. [1] Variants A to D are known from Siliquariaspongia mirabilis and E throuh H are derived from Stelletta clavosa. [2] Mirabamides have a macrocyclic region closed through an ester bond between the C-terminus and a 𝛽-hydroxyl group, and terminated with a polyketide moiety or a more simple branched aliphatic acid. [3]
Mirabamide G is a fusion of several amino acids: 2,3 diamino butanoic acid, 3-hydroxyleucine, N-methylthreonine, 2,3-dihydroxy-2,6,8-trimethyldeca-(4Z,6E)-dienoic acid, 3-methoxy alanine, β-methoxytyrosine, 3,4-dimethylglutamine. [4]
attribution: Contains text from the CC/BY/4.0 licensed "Chemical Reactivity Properties, pKa Values, AGEs Inhibitor Abilities and Bioactivity Scores of the Mirabamides A–H Peptides of Marine Origin Studied by Means of Conceptual DFT" by Lazcano-Perez et al.
![]() Mirabamide A–D
| |
Identifiers | |
---|---|
3D model (
JSmol)
|
|
ChEBI |
|
ChEMBL | |
ChemSpider | |
PubChem
CID
|
|
| |
| |
Except where otherwise noted, data are given for materials in their
standard state (at 25 °C [77 °F], 100 kPa).
|
Mirabamides are sea sponge isolates that inhibit HIV-1 fusion. [1] Variants A to D are known from Siliquariaspongia mirabilis and E throuh H are derived from Stelletta clavosa. [2] Mirabamides have a macrocyclic region closed through an ester bond between the C-terminus and a 𝛽-hydroxyl group, and terminated with a polyketide moiety or a more simple branched aliphatic acid. [3]
Mirabamide G is a fusion of several amino acids: 2,3 diamino butanoic acid, 3-hydroxyleucine, N-methylthreonine, 2,3-dihydroxy-2,6,8-trimethyldeca-(4Z,6E)-dienoic acid, 3-methoxy alanine, β-methoxytyrosine, 3,4-dimethylglutamine. [4]
attribution: Contains text from the CC/BY/4.0 licensed "Chemical Reactivity Properties, pKa Values, AGEs Inhibitor Abilities and Bioactivity Scores of the Mirabamides A–H Peptides of Marine Origin Studied by Means of Conceptual DFT" by Lazcano-Perez et al.