In molecular biology,
microRNAs function to regulate the expression levels of other genes by several mechanisms. The miR-449 microRNA family encompasses three homologous small
RNA molecules (miR-449a/b/c). This miR-449 cluster is located in the second intron of the CDC20B gene which both are co-transcribed.[1] This miR-449 family belongs to the
miR-34/
miR-449 superfamily of
microRNAs that is composed of six homologous miRNAs, named miR-34a/b/c and miR-449a/b/c[1][2].They are grouped together in the same superfamily, as their seed region and their adjacent nucleotide sequences are largely conserved. The miR-449 miRNAs control the differentiation of multiciliated cells in vertebrates.[1][2]
Ma L, Li N, He X, Zhang Q (February 2011). "[miR-449b and miR-34c on inducing down-regulation of cell cycle-related proteins and cycle arrests in SKOV3-ipl cell, an ovarian cancer cell line]". Beijing da Xue Xue Bao. Yi Xue Ban = Journal of Peking University. Health Sciences. 43 (1): 129–33.
PMID21321636.
Wang XY, Wu MH, Liu F, Li Y, Li N, Li GY, Shen SR (December 2010). "Differential miRNA expression and their target genes between NGX6-positive and negative colon cancer cells". Molecular and Cellular Biochemistry. 345 (1–2): 283–90.
doi:
10.1007/s11010-010-0582-7.
PMID20859756.
S2CID27292546.
Wu W, Lin Z, Zhuang Z, Liang X (February 2009). "Expression profile of mammalian microRNAs in endometrioid adenocarcinoma". European Journal of Cancer Prevention. 18 (1): 50–5.
doi:
10.1097/CEJ.0b013e328305a07a.
PMID19077565.
S2CID205549917.
In molecular biology,
microRNAs function to regulate the expression levels of other genes by several mechanisms. The miR-449 microRNA family encompasses three homologous small
RNA molecules (miR-449a/b/c). This miR-449 cluster is located in the second intron of the CDC20B gene which both are co-transcribed.[1] This miR-449 family belongs to the
miR-34/
miR-449 superfamily of
microRNAs that is composed of six homologous miRNAs, named miR-34a/b/c and miR-449a/b/c[1][2].They are grouped together in the same superfamily, as their seed region and their adjacent nucleotide sequences are largely conserved. The miR-449 miRNAs control the differentiation of multiciliated cells in vertebrates.[1][2]
Ma L, Li N, He X, Zhang Q (February 2011). "[miR-449b and miR-34c on inducing down-regulation of cell cycle-related proteins and cycle arrests in SKOV3-ipl cell, an ovarian cancer cell line]". Beijing da Xue Xue Bao. Yi Xue Ban = Journal of Peking University. Health Sciences. 43 (1): 129–33.
PMID21321636.
Wang XY, Wu MH, Liu F, Li Y, Li N, Li GY, Shen SR (December 2010). "Differential miRNA expression and their target genes between NGX6-positive and negative colon cancer cells". Molecular and Cellular Biochemistry. 345 (1–2): 283–90.
doi:
10.1007/s11010-010-0582-7.
PMID20859756.
S2CID27292546.
Wu W, Lin Z, Zhuang Z, Liang X (February 2009). "Expression profile of mammalian microRNAs in endometrioid adenocarcinoma". European Journal of Cancer Prevention. 18 (1): 50–5.
doi:
10.1097/CEJ.0b013e328305a07a.
PMID19077565.
S2CID205549917.