MicroRNA 7-2 is a non-protein-coding
gene product that in humans is encoded by the MIR7-2
gene.
[3]
Function
microRNAs (miRNAs) are short (20-24 nt) non-coding
RNAs that are involved in
post-transcriptional regulation of
gene expression in
multicellular organisms by affecting both the stability and
translation of
mRNAs. miRNAs are transcribed by
RNA polymerase II as part of capped and
polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.
MicroRNA 7-2 is a non-protein-coding
gene product that in humans is encoded by the MIR7-2
gene.
[3]
Function
microRNAs (miRNAs) are short (20-24 nt) non-coding
RNAs that are involved in
post-transcriptional regulation of
gene expression in
multicellular organisms by affecting both the stability and
translation of
mRNAs. miRNAs are transcribed by
RNA polymerase II as part of capped and
polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.