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ATC code | |
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CAS Number | |
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DrugBank | |
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CompTox Dashboard ( EPA) | |
ECHA InfoCard | 100.016.147 |
Chemical and physical data | |
Formula | C12H11I3N2O4 |
Molar mass | 627.943 g·mol−1 |
3D model ( JSmol) | |
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Metrizoic acid is a pharmaceutical drug that was used as an iodinated contrast medium for X-ray imaging. Its uses included angiography [1] (imaging of blood vessels and heart chambers) and urography [2] (imaging of the urinary tract), but it has been discontinued, at least in the US. [3]
It was used in form of its salts, metrizoates. Due to its high osmolality, metrizoic acid had a risk of inducing allergic reactions higher than that of lower osmolar contrast media. [4]
The iodine content of metrizoate ranged from 370 mg/ml to 440 mg/ml, with osmolarity has high as 2100 mOsm/kg. The viscosity is 3.4 cP at 37 degree Celsius (human body temperature). [5]
Side effects of metrizoate are: urticaria, headache, nausea, vomiting, dizziness, and hypotension. Other side effects include minor electrocardiographic changes such as tachycardia, bradycardia, and inversion of T waves. [6]
Clinical data | |
---|---|
ATC code | |
Identifiers | |
| |
CAS Number | |
PubChem CID | |
DrugBank | |
ChemSpider | |
UNII | |
KEGG | |
ChEBI | |
ChEMBL | |
CompTox Dashboard ( EPA) | |
ECHA InfoCard | 100.016.147 |
Chemical and physical data | |
Formula | C12H11I3N2O4 |
Molar mass | 627.943 g·mol−1 |
3D model ( JSmol) | |
| |
|
Metrizoic acid is a pharmaceutical drug that was used as an iodinated contrast medium for X-ray imaging. Its uses included angiography [1] (imaging of blood vessels and heart chambers) and urography [2] (imaging of the urinary tract), but it has been discontinued, at least in the US. [3]
It was used in form of its salts, metrizoates. Due to its high osmolality, metrizoic acid had a risk of inducing allergic reactions higher than that of lower osmolar contrast media. [4]
The iodine content of metrizoate ranged from 370 mg/ml to 440 mg/ml, with osmolarity has high as 2100 mOsm/kg. The viscosity is 3.4 cP at 37 degree Celsius (human body temperature). [5]
Side effects of metrizoate are: urticaria, headache, nausea, vomiting, dizziness, and hypotension. Other side effects include minor electrocardiographic changes such as tachycardia, bradycardia, and inversion of T waves. [6]