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Melanocyte-inhibiting factor
Clinical data
MedlinePlus a605038
Routes of
administration		IV
Pharmacokinetic data
Bioavailability100% (injected)
Metabolismplasma protease enzymes
ExcretionN/A
Identifiers
  • (S)-N-((S)-1-(2-amino-2-oxoethylamino)-4-methyl-1-oxopentan-2-yl)pyrrolidine-2-carboxamide
CAS Number
PubChem CID
ChemSpider
UNII
CompTox Dashboard ( EPA)
ECHA InfoCard 100.016.276 Edit this at Wikidata
Chemical and physical data
FormulaC13H24N4O3
Molar mass284.360 g·mol−1
3D model ( JSmol)
  • NC(CNC([C@H](CC(C)C)NC([C@@H]1CCCN1)=O)=O)=O
  • InChI=1S/C13H24N4O3/c1-8(2)6-10(12(19)16-7-11(14)18)17-13(20)9-4-3-5-15-9/h8-10,15H,3-7H2,1-2H3,(H2,14,18)(H,16,19)(H,17,20)/t9-,10-/m0/s1 ☒N
  • Key:NOOJLZTTWSNHOX-UWVGGRQHSA-N ☒N
 ☒NcheckY  (what is this?)   (verify)

Melanocyte-inhibiting factor (also known as Pro- Leu- Gly-NH2, Melanostatin, MSH release–inhibiting hormone or MIF-1) is an endogenous peptide fragment derived from cleavage of the hormone oxytocin, but having generally different actions in the body. [1] [2] MIF-1 produces multiple effects, both blocking the effects of opioid receptor activation, [3] [4] [5] [6] [7] [8] while at the same time acting as a positive allosteric modulator of the D2 and D4 dopamine receptor subtypes, [9] [10] [11] [12] [13] [14] [15] [16] [17] as well as inhibiting release of other neuropeptides such as alpha-MSH, [18] [19] [20] and potentiating melatonin activity. [21]

This complex mix of actions produces a profile of antidepressant, [22] [23] [24] nootropic, [25] [26] [27] [28] and anti- Parkinsonian effects when MIF-1 is administered, [29] [30] [31] and it has been investigated for various medical uses. MIF-1 is unusually resistant to metabolism in the bloodstream, [32] and crosses the blood–brain barrier easily, [33] [34] though it is poorly active orally and is usually injected. Several other closely related peptides with important actions in the body include Tyr-MIF-1 and endomorphin-1 and -2. [35] [36] [37] [38] [39]

See also

References

  1. ^ Celis ME, Taleisnik S, Walter R (July 1971). "Regulation of formation and proposed structure of the factor inhibiting the release of melanocyte-stimulating hormone". Proceedings of the National Academy of Sciences of the United States of America. 68 (7): 1428–33. Bibcode: 1971PNAS...68.1428C. doi: 10.1073/pnas.68.7.1428. PMC  389210. PMID  5283931.
  2. ^ Petersson M, Uvnäs-Moberg K (December 2004). "Prolyl-leucyl-glycinamide shares some effects with oxytocin but decreases oxytocin levels". Physiology & Behavior. 83 (3): 475–81. doi: 10.1016/j.physbeh.2004.08.034. PMID  15581670. S2CID  42596717.
  3. ^ Chiu S, Mishra RK (January 1979). "Antagonism of morphine-induced catalepsy by L-prolyl-L-leucyl-glycinamide". European Journal of Pharmacology. 53 (2): 119–25. doi: 10.1016/0014-2999(79)90156-0. PMID  32058.
  4. ^ Dickinson SL, Slater P (1980). "Opiate receptor antagonism by L-prolyl-L-leucyl-glycinamide, MIF-I". Peptides. 1 (4): 293–9. doi: 10.1016/0196-9781(80)90006-6. PMID  6117839. S2CID  3832175.
  5. ^ Contreras PC, Takemori AE (June 1984). "Effect of prolyl-leucyl-glycinamide and alpha-melanocyte-stimulating hormone on levorphanol-induced analgesia, tolerance and dependence". Life Sciences. 34 (26): 2559–66. doi: 10.1016/0024-3205(84)90041-9. PMID  6146083.
  6. ^ Ehrensing RH, Kastin AJ, Michell GF (December 1984). "Antagonism of morphine analgesia by prolyl-leucyl-glycinamide (MIF-1) in humans". Pharmacology Biochemistry and Behavior. 21 (6): 975–8. doi: 10.1016/S0091-3057(84)80083-0. PMID  6151672. S2CID  21761862.
  7. ^ Galina ZH, Kastin AJ (December 1986). "Existence of antiopiate systems as illustrated by MIF-1/Tyr-MIF-1". Life Sciences. 39 (23): 2153–9. doi: 10.1016/0024-3205(86)90391-7. PMID  2878336.
  8. ^ Bocheva A, Dzambazova-Maximova E (November 2004). "Antiopioid properties of the TYR-MIF-1 family". Methods and Findings in Experimental and Clinical Pharmacology. 26 (9): 673–7. doi: 10.1358/mf.2004.26.9.872564. PMID  15632952.
  9. ^ Kostrzewa RM, Spirtes MA, Klara JW, Christensen CW, Kastin AJ, Joh TH (1976). "Effects of L-prolyl-L-leucyl-glycine amide (MIF-I) on dopaminergic neurons". Pharmacology Biochemistry and Behavior. 5 (Suppl 1): 125–7. doi: 10.1016/0091-3057(76)90340-3. PMID  13412. S2CID  28341101.
  10. ^ Singhal RL, Rastogi RB (February 1982). "MIF-1: effects on norepinephrine, dopamine and serotonin metabolism in certain discrete brain regions". Pharmacology Biochemistry and Behavior. 16 (2): 229–33. doi: 10.1016/0091-3057(82)90153-8. PMID  6122214. S2CID  44601791.
  11. ^ Chiu P, Rajakumar G, Chiu S, Johnson RL, Mishra RK (1985). "Mesolimbic and striatal dopamine receptor supersensitivity: prophylactic and reversal effects of L-prolyl-L-leucyl-glycinamide (PLG)". Peptides. 6 (2): 179–83. doi: 10.1016/0196-9781(85)90036-1. PMID  2863809. S2CID  41473997.
  12. ^ Xu DL, Yu WC, Pan GB, Chen SD (1987). "Mechanism of action of L-leucyl-glycinamide and its effect on Parkinson's disease". Advances in Neurology. 45: 587–90. PMID  2881450.
  13. ^ Verma V, Mann A, Costain W, Pontoriero G, Castellano JM, Skoblenick K, Gupta SK, Pristupa Z, Niznik HB, Johnson RL, Nair VD, Mishra RK (December 2005). "Modulation of agonist binding to human dopamine receptor subtypes by L-prolyl-L-leucyl-glycinamide and a peptidomimetic analog" (PDF). The Journal of Pharmacology and Experimental Therapeutics. 315 (3): 1228–36. doi: 10.1124/jpet.105.091256. PMID  16126839. S2CID  20193713. Archived from the original (PDF) on 2019-02-27.
  14. ^ Fisher A, Mann A, Verma V, Thomas N, Mishra RK, Johnson RL (January 2006). "Design and synthesis of photoaffinity-labeling ligands of the L-prolyl-L-leucylglycinamide binding site involved in the allosteric modulation of the dopamine receptor". Journal of Medicinal Chemistry. 49 (1): 307–17. doi: 10.1021/jm050644n. PMC  2533518. PMID  16392815.
  15. ^ Vartak AP, Skoblenick K, Thomas N, Mishra RK, Johnson RL (December 2007). "Allosteric modulation of the dopamine receptor by conformationally constrained type VI beta-turn peptidomimetics of Pro-Leu-Gly-NH2". Journal of Medicinal Chemistry. 50 (26): 6725–9. doi: 10.1021/jm070895r. PMC  2529021. PMID  18052024.
  16. ^ Raghavan B, Skoblenick KJ, Bhagwanth S, Argintaru N, Mishra RK, Johnson RL (April 2009). "Allosteric modulation of the dopamine D2 receptor by Pro-Leu-Gly-NH2 peptidomimetics constrained in either a polyproline II helix or a type II beta-turn conformation". Journal of Medicinal Chemistry. 52 (7): 2043–51. doi: 10.1021/jm801575w. PMC  2712934. PMID  19271750.
  17. ^ Mann A, Verma V, Basu D, Skoblenick KJ, Beyaert MG, Fisher A, Thomas N, Johnson RL, Mishra RK (September 2010). "Specific binding of photoaffinity-labeling peptidomimetics of Pro-Leu-Gly-NH2 to the dopamine D2L receptor: evidence for the allosteric modulation of the dopamine receptor". European Journal of Pharmacology. 641 (2–3): 96–101. doi: 10.1016/j.ejphar.2010.05.018. PMC  2907365. PMID  20639138.
  18. ^ Scimonelli T, Celis ME (1982). "Inhibition by L-prolyl-L-leucyl-glycinamide (PLG) of alpha-melanocyte stimulating hormone release from hypothalamic slices". Peptides. 3 (6): 885–9. doi: 10.1016/0196-9781(82)90055-9. PMID  6132363. S2CID  3880592.
  19. ^ McCullen RK, Peiffer RL, Jennes L, Hernandez DE (1988). "Inhibition by MIF-I of alpha-MSH induced increase of intraocular pressure and miosis in rabbits". Neuropeptides. 12 (4): 213–7. doi: 10.1016/0143-4179(88)90057-1. PMID  2907121. S2CID  54378746.
  20. ^ Caballero C, Celis ME (May 1993). "The effect of the blockade of alpha-melanocyte-stimulating hormone on LH release in the rat". The Journal of Endocrinology. 137 (2): 197–202. doi: 10.1677/joe.0.1370197. PMID  8100849.
  21. ^ Sandyk R (May 1990). "MIF-induced augmentation of melatonin functions: possible relevance to mechanisms of action of MIF-1 in movement disorders". The International Journal of Neuroscience. 52 (1–2): 59–65. doi: 10.3109/00207459008994244. PMID  1979968.
  22. ^ Pignatiello MF, Olson GA, Kastin AJ, Ehrensing RH, McLean JH, Olson RD (March 1989). "MIF-1 is active in a chronic stress animal model of depression". Pharmacology Biochemistry and Behavior. 32 (3): 737–42. doi: 10.1016/0091-3057(89)90027-0. PMID  2568001. S2CID  27994919.
  23. ^ Kostowski W, Danysz W, Dyr W, Jankowska E, Krzaścik P, Pałejko W, Stefański R, Płaźnik A (1991). "MIF-1 potentiates the action of tricyclic antidepressants in an animal model of depression". Peptides. 12 (5): 915–8. doi: 10.1016/0196-9781(91)90037-p. PMID  1686934. S2CID  3846846.
  24. ^ Ehrensing RH, Kastin AJ, Wurzlow GF, Michell GF, Mebane AH (August 1994). "Improvement in major depression after low subcutaneous doses of MIF-1". Journal of Affective Disorders. 31 (4): 227–33. doi: 10.1016/0165-0327(94)90098-1. PMID  7989637.
  25. ^ Stratton LO, Kastin AJ (1975). "Increased acquisition of a complex appetitive task after MSH and MIF". Pharmacology Biochemistry and Behavior. 3 (5): 901–4. doi: 10.1016/0091-3057(75)90124-0. PMID  1801. S2CID  7471749.
  26. ^ Davis JL, Pico RM, Cherkin A (November 1982). "Memory enhancement induced in chicks by L-prolyl-L-leucyl-glycinamide". Pharmacology Biochemistry and Behavior. 17 (5): 893–6. doi: 10.1016/0091-3057(82)90467-1. PMID  6129646. S2CID  33757710.
  27. ^ d'Amore A, Pieretti S, Palazzesi S, Pezzini G, Chiarotti F, Scorza T, Loizzo A (1990). "MIF-1 can accelerate neuromotor, EEG and behavioral development in mice". Peptides. 11 (3): 527–32. doi: 10.1016/0196-9781(90)90054-9. PMID  1974348. S2CID  29413931.
  28. ^ Khan RS, Yu C, Kastin AJ, He Y, Ehrensing RH, Hsuchou H, Stone KP, Pan W (2010). "Brain Activation by Peptide Pro-Leu-Gly-NH(2) (MIF-1)". International Journal of Peptides. 2010: 1–10. doi: 10.1155/2010/537639. PMC  2915805. PMID  20721355.
  29. ^ Kastin AJ, Ehrensing RH, Olson RD, Coy DH (1980). "Neurological effects of MIF-1, MSH, and opiate peptides in clinical studies". International Journal of Neurology. 14 (2–4): 205–9. PMID  6152908.
  30. ^ Katzenschlager R, Jackson MJ, Rose S, Stockwell K, Tayarani-Binazir KA, Zubair M, Smith LA, Jenner P, Lees AJ (April 2007). "Antiparkinsonian activity of L-propyl-L-leucyl-glycinamide or melanocyte-inhibiting factor in MPTP-treated common marmosets". Movement Disorders. 22 (5): 715–9. doi: 10.1002/mds.21256. PMID  17373723. S2CID  32101673.
  31. ^ Castellano JM, Batrynchuk J, Dolbeare K, Verma V, Mann A, Skoblenick KJ, Johnson RL, Mishra RK (October 2007). "MIF-1 and its peptidomimetic analogs attenuate haloperidol-induced vacuous chewing movements and modulate apomorphine-induced rotational behavior in 6-hydroxydopamine-lesioned rats". Peptides. 28 (10): 2009–15. doi: 10.1016/j.peptides.2007.07.026. PMID  17766011. S2CID  12114315.
  32. ^ Kastin AJ, Hahn K, Erchegyi J, Zadina JE, Hackler L, Palmgren M, Banks WA (February 1994). "Differential metabolism of Tyr-MIF-1 and MIF-1 in rat and human plasma". Biochemical Pharmacology. 47 (4): 699–709. doi: 10.1016/0006-2952(94)90133-3. PMID  7907473.
  33. ^ Reed GW, Olson GA, Olson RD (1994). "The Tyr-MIF-1 family of peptides". Neuroscience and Biobehavioral Reviews. 18 (4): 519–25. doi: 10.1016/0149-7634(94)90005-1. PMID  7708364. S2CID  8794727.
  34. ^ Banks WA, Kastin AJ (January 1994). "Opposite direction of transport across the blood–brain barrier for Tyr-MIF-1 and MIF-1: comparison with morphine". Peptides. 15 (1): 23–9. doi: 10.1016/0196-9781(94)90165-1. PMID  7912427. S2CID  3851330.
  35. ^ Kastin AJ, Hahn K, Zadina JE, Banks WA, Hackler L (April 1995). "Melanocyte-stimulating hormone release-inhibiting factor-1 (MIF-1) can be formed from Tyr-MIF-1 in brain mitochondria but not in brain homogenate". Journal of Neurochemistry. 64 (4): 1855–9. doi: 10.1046/j.1471-4159.1995.64041855.x. PMID  7891114. S2CID  2655168.
  36. ^ Zadina JE, Hackler L, Ge LJ, Kastin AJ (April 1997). "A potent and selective endogenous agonist for the mu-opiate receptor". Nature. 386 (6624): 499–502. Bibcode: 1997Natur.386..499Z. doi: 10.1038/386499a0. PMID  9087409. S2CID  4314764.
  37. ^ Pan W, Kastin AJ (December 2007). "From MIF-1 to endomorphin: the Tyr-MIF-1 family of peptides". Peptides. 28 (12): 2411–34. doi: 10.1016/j.peptides.2007.10.006. PMID  17988762. S2CID  23173843.
  38. ^ Rotzinger S, Lovejoy DA, Tan LA (April 2010). "Behavioral effects of neuropeptides in rodent models of depression and anxiety". Peptides. 31 (4): 736–56. doi: 10.1016/j.peptides.2009.12.015. PMID  20026211. S2CID  44705573.
  39. ^ Dyck B, Guest K, Sookram C, Basu D, Johnson R, Mishra RK (January 2011). "PAOPA, a potent analogue of Pro-Leu-glycinamide and allosteric modulator of the dopamine D2 receptor, prevents NMDA receptor antagonist (MK-801)-induced deficits in social interaction in the rat: implications for the treatment of negative symptoms in schizophrenia". Schizophrenia Research. 125 (1): 88–92. doi: 10.1016/j.schres.2010.09.025. PMC  3010311. PMID  21036015.
Retrieved from " https://en.wikipedia.org/?title=Melanocyte-inhibiting_factor&oldid=1096106623"
From Wikipedia, the free encyclopedia
Melanocyte-inhibiting factor
Clinical data
MedlinePlus a605038
Routes of
administration		IV
Pharmacokinetic data
Bioavailability100% (injected)
Metabolismplasma protease enzymes
ExcretionN/A
Identifiers
  • (S)-N-((S)-1-(2-amino-2-oxoethylamino)-4-methyl-1-oxopentan-2-yl)pyrrolidine-2-carboxamide
CAS Number
PubChem CID
ChemSpider
UNII
CompTox Dashboard ( EPA)
ECHA InfoCard 100.016.276 Edit this at Wikidata
Chemical and physical data
FormulaC13H24N4O3
Molar mass284.360 g·mol−1
3D model ( JSmol)
  • NC(CNC([C@H](CC(C)C)NC([C@@H]1CCCN1)=O)=O)=O
  • InChI=1S/C13H24N4O3/c1-8(2)6-10(12(19)16-7-11(14)18)17-13(20)9-4-3-5-15-9/h8-10,15H,3-7H2,1-2H3,(H2,14,18)(H,16,19)(H,17,20)/t9-,10-/m0/s1 ☒N
  • Key:NOOJLZTTWSNHOX-UWVGGRQHSA-N ☒N
 ☒NcheckY  (what is this?)   (verify)

Melanocyte-inhibiting factor (also known as Pro- Leu- Gly-NH2, Melanostatin, MSH release–inhibiting hormone or MIF-1) is an endogenous peptide fragment derived from cleavage of the hormone oxytocin, but having generally different actions in the body. [1] [2] MIF-1 produces multiple effects, both blocking the effects of opioid receptor activation, [3] [4] [5] [6] [7] [8] while at the same time acting as a positive allosteric modulator of the D2 and D4 dopamine receptor subtypes, [9] [10] [11] [12] [13] [14] [15] [16] [17] as well as inhibiting release of other neuropeptides such as alpha-MSH, [18] [19] [20] and potentiating melatonin activity. [21]

This complex mix of actions produces a profile of antidepressant, [22] [23] [24] nootropic, [25] [26] [27] [28] and anti- Parkinsonian effects when MIF-1 is administered, [29] [30] [31] and it has been investigated for various medical uses. MIF-1 is unusually resistant to metabolism in the bloodstream, [32] and crosses the blood–brain barrier easily, [33] [34] though it is poorly active orally and is usually injected. Several other closely related peptides with important actions in the body include Tyr-MIF-1 and endomorphin-1 and -2. [35] [36] [37] [38] [39]

See also

References

  1. ^ Celis ME, Taleisnik S, Walter R (July 1971). "Regulation of formation and proposed structure of the factor inhibiting the release of melanocyte-stimulating hormone". Proceedings of the National Academy of Sciences of the United States of America. 68 (7): 1428–33. Bibcode: 1971PNAS...68.1428C. doi: 10.1073/pnas.68.7.1428. PMC  389210. PMID  5283931.
  2. ^ Petersson M, Uvnäs-Moberg K (December 2004). "Prolyl-leucyl-glycinamide shares some effects with oxytocin but decreases oxytocin levels". Physiology & Behavior. 83 (3): 475–81. doi: 10.1016/j.physbeh.2004.08.034. PMID  15581670. S2CID  42596717.
  3. ^ Chiu S, Mishra RK (January 1979). "Antagonism of morphine-induced catalepsy by L-prolyl-L-leucyl-glycinamide". European Journal of Pharmacology. 53 (2): 119–25. doi: 10.1016/0014-2999(79)90156-0. PMID  32058.
  4. ^ Dickinson SL, Slater P (1980). "Opiate receptor antagonism by L-prolyl-L-leucyl-glycinamide, MIF-I". Peptides. 1 (4): 293–9. doi: 10.1016/0196-9781(80)90006-6. PMID  6117839. S2CID  3832175.
  5. ^ Contreras PC, Takemori AE (June 1984). "Effect of prolyl-leucyl-glycinamide and alpha-melanocyte-stimulating hormone on levorphanol-induced analgesia, tolerance and dependence". Life Sciences. 34 (26): 2559–66. doi: 10.1016/0024-3205(84)90041-9. PMID  6146083.
  6. ^ Ehrensing RH, Kastin AJ, Michell GF (December 1984). "Antagonism of morphine analgesia by prolyl-leucyl-glycinamide (MIF-1) in humans". Pharmacology Biochemistry and Behavior. 21 (6): 975–8. doi: 10.1016/S0091-3057(84)80083-0. PMID  6151672. S2CID  21761862.
  7. ^ Galina ZH, Kastin AJ (December 1986). "Existence of antiopiate systems as illustrated by MIF-1/Tyr-MIF-1". Life Sciences. 39 (23): 2153–9. doi: 10.1016/0024-3205(86)90391-7. PMID  2878336.
  8. ^ Bocheva A, Dzambazova-Maximova E (November 2004). "Antiopioid properties of the TYR-MIF-1 family". Methods and Findings in Experimental and Clinical Pharmacology. 26 (9): 673–7. doi: 10.1358/mf.2004.26.9.872564. PMID  15632952.
  9. ^ Kostrzewa RM, Spirtes MA, Klara JW, Christensen CW, Kastin AJ, Joh TH (1976). "Effects of L-prolyl-L-leucyl-glycine amide (MIF-I) on dopaminergic neurons". Pharmacology Biochemistry and Behavior. 5 (Suppl 1): 125–7. doi: 10.1016/0091-3057(76)90340-3. PMID  13412. S2CID  28341101.
  10. ^ Singhal RL, Rastogi RB (February 1982). "MIF-1: effects on norepinephrine, dopamine and serotonin metabolism in certain discrete brain regions". Pharmacology Biochemistry and Behavior. 16 (2): 229–33. doi: 10.1016/0091-3057(82)90153-8. PMID  6122214. S2CID  44601791.
  11. ^ Chiu P, Rajakumar G, Chiu S, Johnson RL, Mishra RK (1985). "Mesolimbic and striatal dopamine receptor supersensitivity: prophylactic and reversal effects of L-prolyl-L-leucyl-glycinamide (PLG)". Peptides. 6 (2): 179–83. doi: 10.1016/0196-9781(85)90036-1. PMID  2863809. S2CID  41473997.
  12. ^ Xu DL, Yu WC, Pan GB, Chen SD (1987). "Mechanism of action of L-leucyl-glycinamide and its effect on Parkinson's disease". Advances in Neurology. 45: 587–90. PMID  2881450.
  13. ^ Verma V, Mann A, Costain W, Pontoriero G, Castellano JM, Skoblenick K, Gupta SK, Pristupa Z, Niznik HB, Johnson RL, Nair VD, Mishra RK (December 2005). "Modulation of agonist binding to human dopamine receptor subtypes by L-prolyl-L-leucyl-glycinamide and a peptidomimetic analog" (PDF). The Journal of Pharmacology and Experimental Therapeutics. 315 (3): 1228–36. doi: 10.1124/jpet.105.091256. PMID  16126839. S2CID  20193713. Archived from the original (PDF) on 2019-02-27.
  14. ^ Fisher A, Mann A, Verma V, Thomas N, Mishra RK, Johnson RL (January 2006). "Design and synthesis of photoaffinity-labeling ligands of the L-prolyl-L-leucylglycinamide binding site involved in the allosteric modulation of the dopamine receptor". Journal of Medicinal Chemistry. 49 (1): 307–17. doi: 10.1021/jm050644n. PMC  2533518. PMID  16392815.
  15. ^ Vartak AP, Skoblenick K, Thomas N, Mishra RK, Johnson RL (December 2007). "Allosteric modulation of the dopamine receptor by conformationally constrained type VI beta-turn peptidomimetics of Pro-Leu-Gly-NH2". Journal of Medicinal Chemistry. 50 (26): 6725–9. doi: 10.1021/jm070895r. PMC  2529021. PMID  18052024.
  16. ^ Raghavan B, Skoblenick KJ, Bhagwanth S, Argintaru N, Mishra RK, Johnson RL (April 2009). "Allosteric modulation of the dopamine D2 receptor by Pro-Leu-Gly-NH2 peptidomimetics constrained in either a polyproline II helix or a type II beta-turn conformation". Journal of Medicinal Chemistry. 52 (7): 2043–51. doi: 10.1021/jm801575w. PMC  2712934. PMID  19271750.
  17. ^ Mann A, Verma V, Basu D, Skoblenick KJ, Beyaert MG, Fisher A, Thomas N, Johnson RL, Mishra RK (September 2010). "Specific binding of photoaffinity-labeling peptidomimetics of Pro-Leu-Gly-NH2 to the dopamine D2L receptor: evidence for the allosteric modulation of the dopamine receptor". European Journal of Pharmacology. 641 (2–3): 96–101. doi: 10.1016/j.ejphar.2010.05.018. PMC  2907365. PMID  20639138.
  18. ^ Scimonelli T, Celis ME (1982). "Inhibition by L-prolyl-L-leucyl-glycinamide (PLG) of alpha-melanocyte stimulating hormone release from hypothalamic slices". Peptides. 3 (6): 885–9. doi: 10.1016/0196-9781(82)90055-9. PMID  6132363. S2CID  3880592.
  19. ^ McCullen RK, Peiffer RL, Jennes L, Hernandez DE (1988). "Inhibition by MIF-I of alpha-MSH induced increase of intraocular pressure and miosis in rabbits". Neuropeptides. 12 (4): 213–7. doi: 10.1016/0143-4179(88)90057-1. PMID  2907121. S2CID  54378746.
  20. ^ Caballero C, Celis ME (May 1993). "The effect of the blockade of alpha-melanocyte-stimulating hormone on LH release in the rat". The Journal of Endocrinology. 137 (2): 197–202. doi: 10.1677/joe.0.1370197. PMID  8100849.
  21. ^ Sandyk R (May 1990). "MIF-induced augmentation of melatonin functions: possible relevance to mechanisms of action of MIF-1 in movement disorders". The International Journal of Neuroscience. 52 (1–2): 59–65. doi: 10.3109/00207459008994244. PMID  1979968.
  22. ^ Pignatiello MF, Olson GA, Kastin AJ, Ehrensing RH, McLean JH, Olson RD (March 1989). "MIF-1 is active in a chronic stress animal model of depression". Pharmacology Biochemistry and Behavior. 32 (3): 737–42. doi: 10.1016/0091-3057(89)90027-0. PMID  2568001. S2CID  27994919.
  23. ^ Kostowski W, Danysz W, Dyr W, Jankowska E, Krzaścik P, Pałejko W, Stefański R, Płaźnik A (1991). "MIF-1 potentiates the action of tricyclic antidepressants in an animal model of depression". Peptides. 12 (5): 915–8. doi: 10.1016/0196-9781(91)90037-p. PMID  1686934. S2CID  3846846.
  24. ^ Ehrensing RH, Kastin AJ, Wurzlow GF, Michell GF, Mebane AH (August 1994). "Improvement in major depression after low subcutaneous doses of MIF-1". Journal of Affective Disorders. 31 (4): 227–33. doi: 10.1016/0165-0327(94)90098-1. PMID  7989637.
  25. ^ Stratton LO, Kastin AJ (1975). "Increased acquisition of a complex appetitive task after MSH and MIF". Pharmacology Biochemistry and Behavior. 3 (5): 901–4. doi: 10.1016/0091-3057(75)90124-0. PMID  1801. S2CID  7471749.
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