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Names | |
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Other names
Maytansin
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Identifiers | |
3D model (
JSmol)
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ChEBI | |
ChEMBL | |
ChemSpider | |
ECHA InfoCard | 100.047.944 |
PubChem
CID
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|
UNII | |
CompTox Dashboard (
EPA)
|
|
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Properties | |
C34H46ClN3O10 | |
Molar mass | 692.20 g/mol |
Except where otherwise noted, data are given for materials in their
standard state (at 25 °C [77 °F], 100 kPa).
|
Maitansine ( INN), or maytansine ( USAN), is a cytotoxic agent. It inhibits the assembly of microtubules by binding to tubulin at the rhizoxin binding site. [1]
It is a macrolide of the ansamycin type and can be isolated from plants of the genus Maytenus. [1]
Derivatives of maitansine are known as maytansinoids. [2] [3] Some are being investigated as the cytotoxic component of antibody-drug conjugates for cancer treatment, [4] and the antibody-drug conjugate trastuzumab emtansine is an approved drug for the treatment of certain kinds of breast cancer in the EU and in the US. [5] [6]
Examples of maytansinoids are:
![]() | |
Names | |
---|---|
Other names
Maytansin
| |
Identifiers | |
3D model (
JSmol)
|
|
ChEBI | |
ChEMBL | |
ChemSpider | |
ECHA InfoCard | 100.047.944 |
PubChem
CID
|
|
UNII | |
CompTox Dashboard (
EPA)
|
|
| |
| |
Properties | |
C34H46ClN3O10 | |
Molar mass | 692.20 g/mol |
Except where otherwise noted, data are given for materials in their
standard state (at 25 °C [77 °F], 100 kPa).
|
Maitansine ( INN), or maytansine ( USAN), is a cytotoxic agent. It inhibits the assembly of microtubules by binding to tubulin at the rhizoxin binding site. [1]
It is a macrolide of the ansamycin type and can be isolated from plants of the genus Maytenus. [1]
Derivatives of maitansine are known as maytansinoids. [2] [3] Some are being investigated as the cytotoxic component of antibody-drug conjugates for cancer treatment, [4] and the antibody-drug conjugate trastuzumab emtansine is an approved drug for the treatment of certain kinds of breast cancer in the EU and in the US. [5] [6]
Examples of maytansinoids are: