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Clinical data | |
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Trade names | Livmarli |
Other names | LUM001 |
AHFS/ Drugs.com | Monograph |
MedlinePlus | a621056 |
License data | |
Routes of administration | By mouth |
Drug class | Ileal bile acid transporter (IBAT) inhibitor |
ATC code | |
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Legal status | |
Identifiers | |
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CAS Number |
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DrugBank |
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ChemSpider | |
UNII |
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KEGG | |
ChEMBL |
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CompTox Dashboard ( EPA) | |
Chemical and physical data | |
Formula | C40H56ClN3O4S |
Molar mass | 710.42 g·mol−1 |
3D model ( JSmol) | |
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Maralixibat chloride, sold under the brand name Livmarli, is a medication used to treat cholestatic pruritus in people with Alagille syndrome. [5] [6] Maralixibat chloride is an ileal bile acid transporter (IBAT) inhibitor. [5]
The most common side effects include diarrhea and abdominal pain (belly ache). [6]
Maralixibat chloride was approved for medical use in the United States in September 2021, [5] [7] [8] [9] and in the European Union in December 2022. [6]
Maralixibat chloride is indicated for the treatment of cholestatic pruritus in patients with Alagille syndrome. [5] [6]
The U.S. Food and Drug Administration (FDA) granted the application for maralixibat chloride orphan drug designations in 2013, [10] [11] and in 2020. [12] [13]
In October 2022, the Committee for Medicinal Products for Human Use (CHMP) of the European Medicines Agency (EMA) adopted a positive opinion, recommending the granting of a marketing authorization under exceptional circumstances for the medicinal product Livmarli, intended for the treatment of cholestatic pruritus in patients with Alagille syndrome (ALGS). [14] The applicant for this medicinal product is Mirum Pharmaceuticals International B.V. [14] Maralixibat chloride was approved for medical use in the European Union in December 2022. [6] [15]
Maralixibat chloride is the international nonproprietary name (INN). [16]
![]() | |
Clinical data | |
---|---|
Trade names | Livmarli |
Other names | LUM001 |
AHFS/ Drugs.com | Monograph |
MedlinePlus | a621056 |
License data | |
Routes of administration | By mouth |
Drug class | Ileal bile acid transporter (IBAT) inhibitor |
ATC code | |
Legal status | |
Legal status | |
Identifiers | |
| |
CAS Number |
|
DrugBank |
|
ChemSpider | |
UNII |
|
KEGG | |
ChEMBL |
|
CompTox Dashboard ( EPA) | |
Chemical and physical data | |
Formula | C40H56ClN3O4S |
Molar mass | 710.42 g·mol−1 |
3D model ( JSmol) | |
| |
|
Maralixibat chloride, sold under the brand name Livmarli, is a medication used to treat cholestatic pruritus in people with Alagille syndrome. [5] [6] Maralixibat chloride is an ileal bile acid transporter (IBAT) inhibitor. [5]
The most common side effects include diarrhea and abdominal pain (belly ache). [6]
Maralixibat chloride was approved for medical use in the United States in September 2021, [5] [7] [8] [9] and in the European Union in December 2022. [6]
Maralixibat chloride is indicated for the treatment of cholestatic pruritus in patients with Alagille syndrome. [5] [6]
The U.S. Food and Drug Administration (FDA) granted the application for maralixibat chloride orphan drug designations in 2013, [10] [11] and in 2020. [12] [13]
In October 2022, the Committee for Medicinal Products for Human Use (CHMP) of the European Medicines Agency (EMA) adopted a positive opinion, recommending the granting of a marketing authorization under exceptional circumstances for the medicinal product Livmarli, intended for the treatment of cholestatic pruritus in patients with Alagille syndrome (ALGS). [14] The applicant for this medicinal product is Mirum Pharmaceuticals International B.V. [14] Maralixibat chloride was approved for medical use in the European Union in December 2022. [6] [15]
Maralixibat chloride is the international nonproprietary name (INN). [16]