mannan-binding lectin serine peptidase 1 (C4/C2 activating component of Ra-reactive factor) | |||||||
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Identifiers | |||||||
Symbol | MASP1 | ||||||
Alt. symbols | CRARF, PRSS5 | ||||||
NCBI gene | 5648 | ||||||
HGNC | 6901 | ||||||
OMIM | 600521 | ||||||
RefSeq | NM_001879 | ||||||
UniProt | P48740 | ||||||
Other data | |||||||
Locus | Chr. 3 q27-q28 | ||||||
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Mannose-binding lectin-associated protein of 44 kDa (MAp44) is a protein arising from the human MASP1 gene. MASP-1, MASP-3 and MAp44 are alternative splice products of the MASP1 gene. MAp44 has been suggested to act as a competitive inhibitor of lectin pathway activation, by displacing MASP-2 from MBL, hence preventing cleavage of C4 and C2 [1]
mannan-binding lectin serine peptidase 1 (C4/C2 activating component of Ra-reactive factor) | |||||||
---|---|---|---|---|---|---|---|
Identifiers | |||||||
Symbol | MASP1 | ||||||
Alt. symbols | CRARF, PRSS5 | ||||||
NCBI gene | 5648 | ||||||
HGNC | 6901 | ||||||
OMIM | 600521 | ||||||
RefSeq | NM_001879 | ||||||
UniProt | P48740 | ||||||
Other data | |||||||
Locus | Chr. 3 q27-q28 | ||||||
|
Mannose-binding lectin-associated protein of 44 kDa (MAp44) is a protein arising from the human MASP1 gene. MASP-1, MASP-3 and MAp44 are alternative splice products of the MASP1 gene. MAp44 has been suggested to act as a competitive inhibitor of lectin pathway activation, by displacing MASP-2 from MBL, hence preventing cleavage of C4 and C2 [1]