The mSin3 interaction domain (SID) is an interaction domain which is present on several transcriptional repressor proteins including TGFβ (
transforming growth factor β) and Mad. It interacts with the paired
amphipathic
alpha-helix 2 (PAH2) domain of
mSin3, a
transcriptional repressor domain that is attached to transcription repressor proteins such as the
mSin3A corepressor.
Action of histone deacetylase 1 and 2 (HDAC1/2) is induced by the interaction of mSin3A with a multi-protein complex containing HDAC1/2. Transcription is also repressed by histone deacetylase-independent means.
The mSin3 interaction domain (SID) is an interaction domain which is present on several transcriptional repressor proteins including TGFβ (
transforming growth factor β) and Mad. It interacts with the paired
amphipathic
alpha-helix 2 (PAH2) domain of
mSin3, a
transcriptional repressor domain that is attached to transcription repressor proteins such as the
mSin3A corepressor.
Action of histone deacetylase 1 and 2 (HDAC1/2) is induced by the interaction of mSin3A with a multi-protein complex containing HDAC1/2. Transcription is also repressed by histone deacetylase-independent means.