28S ribosomal protein S18b, mitochondrial is a
protein that in humans is encoded by the MRPS18Bgene.[5][6]
Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the
mitochondrion. Mitochondrial ribosomes (
mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to
rRNA composition compared to
prokaryotic ribosomes, where this ratio is reversed.
Another difference between mammalian mitoribosomes and prokaryotic
ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence
homology. This gene encodes a 28S subunit protein that belongs to the ribosomal protein S18P family. The encoded protein is one of three that has significant sequence similarity to
bacterial S18 proteins. The primary sequences of the three human mitochondrial S18 proteins are no more closely related to each other than they are to the prokaryotic S18 proteins.
Pseudogenes corresponding to this gene are found on
chromosomes 1q and 2q.[6]
Zhang Z, Gerstein M (2003). "Identification and characterization of over 100 mitochondrial ribosomal protein pseudogenes in the human genome". Genomics. 81 (5): 468–80.
doi:
10.1016/S0888-7543(03)00004-1.
PMID12706105.
28S ribosomal protein S18b, mitochondrial is a
protein that in humans is encoded by the MRPS18Bgene.[5][6]
Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the
mitochondrion. Mitochondrial ribosomes (
mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to
rRNA composition compared to
prokaryotic ribosomes, where this ratio is reversed.
Another difference between mammalian mitoribosomes and prokaryotic
ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence
homology. This gene encodes a 28S subunit protein that belongs to the ribosomal protein S18P family. The encoded protein is one of three that has significant sequence similarity to
bacterial S18 proteins. The primary sequences of the three human mitochondrial S18 proteins are no more closely related to each other than they are to the prokaryotic S18 proteins.
Pseudogenes corresponding to this gene are found on
chromosomes 1q and 2q.[6]
Zhang Z, Gerstein M (2003). "Identification and characterization of over 100 mitochondrial ribosomal protein pseudogenes in the human genome". Genomics. 81 (5): 468–80.
doi:
10.1016/S0888-7543(03)00004-1.
PMID12706105.