From Wikipedia, the free encyclopedia
Protein-coding gene in the species Homo sapiens
Modulator of apoptosis 1 is a
protein that in humans is encoded by the MOAP1
gene .
[5]
[6]
The protein encoded by this gene was identified by its interaction with apoptosis regulator BAX protein. This protein contains a Bcl-2 homology 3 (BH3)-like motif, which is required for the association with BAX. When overexpressed, this gene has been shown to mediate caspase-dependent apoptosis.
[6]
References
^
a
b
c
ENSG00000278268 GRCh38: Ensembl release 89: ENSG00000165943, ENSG00000278268 –
Ensembl , May 2017
^
a
b
c
GRCm38: Ensembl release 89: ENSMUSG00000096458 –
Ensembl , May 2017
^
"Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
^
"Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
^ Tan KO, Tan KM, Chan SL, Yee KS, Bevort M, Ang KC, Yu VC (May 2001).
"MAP-1, a novel proapoptotic protein containing a BH3-like motif that associates with Bax through its Bcl-2 homology domains" . J Biol Chem . 276 (4): 2802–7.
doi :
10.1074/jbc.M008955200 .
PMID
11060313 .
^
a
b
"Entrez Gene: MOAP1 modulator of apoptosis 1" .
Further reading
Hartley JL, Temple GF, Brasch MA (2001).
"DNA cloning using in vitro site-specific recombination" . Genome Res . 10 (11): 1788–95.
doi :
10.1101/gr.143000 .
PMC
310948 .
PMID
11076863 .
Simpson JC, Wellenreuther R, Poustka A, et al. (2001).
"Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing" . EMBO Rep . 1 (3): 287–92.
doi :
10.1093/embo-reports/kvd058 .
PMC
1083732 .
PMID
11256614 .
Strausberg RL, Feingold EA, Grouse LH, et al. (2003).
"Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences" . Proc. Natl. Acad. Sci. U.S.A . 99 (26): 16899–903.
Bibcode :
2002PNAS...9916899M .
doi :
10.1073/pnas.242603899 .
PMC
139241 .
PMID
12477932 .
Ota T, Suzuki Y, Nishikawa T, et al. (2004).
"Complete sequencing and characterization of 21,243 full-length human cDNAs" . Nat. Genet . 36 (1): 40–5.
doi :
10.1038/ng1285 .
PMID
14702039 .
Gerhard DS, Wagner L, Feingold EA, et al. (2004).
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)" . Genome Res . 14 (10B): 2121–7.
doi :
10.1101/gr.2596504 .
PMC
528928 .
PMID
15489334 .
Wiemann S, Arlt D, Huber W, et al. (2004).
"From ORFeome to biology: a functional genomics pipeline" . Genome Res . 14 (10B): 2136–44.
doi :
10.1101/gr.2576704 .
PMC
528930 .
PMID
15489336 .
Baksh S, Tommasi S, Fenton S, et al. (2005).
"The tumor suppressor RASSF1A and MAP-1 link death receptor signaling to Bax conformational change and cell death" . Mol. Cell . 18 (6): 637–50.
doi :
10.1016/j.molcel.2005.05.010 .
PMID
15949439 .
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature . 437 (7062): 1173–8.
Bibcode :
2005Natur.437.1173R .
doi :
10.1038/nature04209 .
PMID
16189514 .
S2CID
4427026 .
Vos MD, Dallol A, Eckfeld K, et al. (2006).
"The RASSF1A tumor suppressor activates Bax via MOAP-1" . J. Biol. Chem . 281 (8): 4557–63.
doi :
10.1074/jbc.M512128200 .
PMID
16344548 .
Mehrle A, Rosenfelder H, Schupp I, et al. (2006).
"The LIFEdb database in 2006" . Nucleic Acids Res . 34 (Database issue): D415–8.
doi :
10.1093/nar/gkj139 .
PMC
1347501 .
PMID
16381901 .
Lim J, Hao T, Shaw C, et al. (2006).
"A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration" . Cell . 125 (4): 801–14.
doi :
10.1016/j.cell.2006.03.032 .
PMID
16713569 .
Fu NY, Sukumaran SK, Yu VC (2007).
"Inhibition of ubiquitin-mediated degradation of MOAP-1 by apoptotic stimuli promotes Bax function in mitochondria" . Proc. Natl. Acad. Sci. U.S.A . 104 (24): 10051–6.
Bibcode :
2007PNAS..10410051F .
doi :
10.1073/pnas.0700007104 .
PMC
1877986 .
PMID
17535899 .