 | This article has multiple issues. Please help
improve it or discuss these issues on the
talk page. (
Learn how and when to remove these template messages)
|
| MISL | |
|---|---|
 Consensus
secondary structure and
sequence conservation of MISL RNA | |
| Identifiers | |
| Symbol | MISL |
| Rfam | RF03079 |
| Other data | |
| RNA type | Gene; sRNA |
| SO | SO:0001263 |
| PDB structures | PDBe |
The Mostly Independently Structured, Large RNA motif (MISL RNA motif) is a conserved RNA structure that was discovered by bioinformatics. [1] The MISL motif is found in Verrucomicrobiota.
MISL RNAs likely function in trans as small RNAs, and average roughly 780 nucleotides in length. In comparison to other similarly sized RNA motifs (e.g., the group II intron, the GOLLD RNA motif), the MISL RNA motif exhibits relatively few long-range base pair interactions, such as distant pseudoknots. The large number of hairpin structures in this motif that essentially do not interact with each other is similar to the structure of CRISPR RNAs, except that hairpins in the MISL RNA motif do not share similarities with one another.
- ^ Weinberg Z, Lünse CE, Corbino KA, Ames TD, Nelson JW, Roth A, Perkins KR, Sherlock ME, Breaker RR (October 2017). "Detection of 224 candidate structured RNAs by comparative analysis of specific subsets of intergenic regions". Nucleic Acids Res. 45 (18): 10811–10823. doi: 10.1093/nar/gkx699. PMC 5737381. PMID 28977401.
| This article has multiple issues. Please help
improve it or discuss these issues on the
talk page. (
Learn how and when to remove these template messages)
|
| MISL | |
|---|---|
|
Consensus
secondary structure and
sequence conservation of MISL RNA | |
| Identifiers | |
| Symbol | MISL |
| Rfam | RF03079 |
| Other data | |
| RNA type | Gene; sRNA |
| SO | SO:0001263 |
| PDB structures | PDBe |
The Mostly Independently Structured, Large RNA motif (MISL RNA motif) is a conserved RNA structure that was discovered by bioinformatics. [1] The MISL motif is found in Verrucomicrobiota.
MISL RNAs likely function in trans as small RNAs, and average roughly 780 nucleotides in length. In comparison to other similarly sized RNA motifs (e.g., the group II intron, the GOLLD RNA motif), the MISL RNA motif exhibits relatively few long-range base pair interactions, such as distant pseudoknots. The large number of hairpin structures in this motif that essentially do not interact with each other is similar to the structure of CRISPR RNAs, except that hairpins in the MISL RNA motif do not share similarities with one another.
- ^ Weinberg Z, Lünse CE, Corbino KA, Ames TD, Nelson JW, Roth A, Perkins KR, Sherlock ME, Breaker RR (October 2017). "Detection of 224 candidate structured RNAs by comparative analysis of specific subsets of intergenic regions". Nucleic Acids Res. 45 (18): 10811–10823. doi: 10.1093/nar/gkx699. PMC 5737381. PMID 28977401.