MicroRNA 941-1 is a human specific
microRNA that is encoded by the MIR941-1
gene.[3]
Function
microRNAs (miRNAs) are short (20-24 nt) non-coding
RNAs that are involved in post-transcriptional regulation of
gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by
RNA polymerase II as part of capped and
polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the
Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a
RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.[3]
Evolution
The miR-941 gene is only found in humans where it first appeared between one and six million years ago. Its copy number and binding sites have decreased with
migration out of Africa. miR-941 regulates genes involved in
cellular differentiation and
neurotransmitter signalling.[4]
MicroRNA 941-1 is a human specific
microRNA that is encoded by the MIR941-1
gene.[3]
Function
microRNAs (miRNAs) are short (20-24 nt) non-coding
RNAs that are involved in post-transcriptional regulation of
gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by
RNA polymerase II as part of capped and
polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the
Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a
RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.[3]
Evolution
The miR-941 gene is only found in humans where it first appeared between one and six million years ago. Its copy number and binding sites have decreased with
migration out of Africa. miR-941 regulates genes involved in
cellular differentiation and
neurotransmitter signalling.[4]